Motif ID: Pitx1

Z-value: 0.545


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 193 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 0.971 ENSMUST00000107377.3
 Tnc
tenascin C
chr15_-_79164477 0.935 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr7_-_15879844 0.932 ENSMUST00000172758.1
ENSMUST00000044434.6
 Crx

cone-rod homeobox containing gene

chr6_+_108213086 0.852 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr18_+_73863672 0.847 ENSMUST00000134847.1
 Mro
maestro
chr14_+_99298652 0.739 ENSMUST00000005279.6
 Klf5
Kruppel-like factor 5
chr6_+_4902913 0.698 ENSMUST00000175889.1
ENSMUST00000168998.2
 Ppp1r9a

protein phosphatase 1, regulatory (inhibitor) subunit 9A

chr1_-_44218952 0.660 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chr14_+_26122609 0.657 ENSMUST00000100810.6
 Duxbl2
doubl homeobox B-like 2
chr14_+_64588112 0.572 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr14_+_25983005 0.566 ENSMUST00000049793.8
 Duxbl1
double homeobox B-like 1
chr5_+_3343893 0.554 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr8_-_46294592 0.535 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr7_-_80403315 0.534 ENSMUST00000147150.1
 Furin
furin (paired basic amino acid cleaving enzyme)
chr11_-_100472725 0.533 ENSMUST00000056665.3
 Klhl11
kelch-like 11
chr9_+_32224457 0.517 ENSMUST00000183121.1
 Arhgap32
Rho GTPase activating protein 32
chr1_-_170110491 0.514 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr11_+_19924403 0.495 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr3_-_84270782 0.485 ENSMUST00000054990.4
 Trim2
tripartite motif-containing 2
chr15_+_4375462 0.484 ENSMUST00000061925.4
 Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.4 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 1.1 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.0 GO:0044838 cell quiescence(GO:0044838)
0.1 1.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 0.9 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.2 0.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.1 0.9 GO:0042045 epithelial fluid transport(GO:0042045)
0.1 0.7 GO:0060576 regulation of microvillus assembly(GO:0032534) intestinal epithelial cell development(GO:0060576)
0.0 0.6 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.2 0.5 GO:1904978 regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.1 0.5 GO:0090472 dibasic protein processing(GO:0090472)
0.1 0.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.5 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.1 0.4 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.4 GO:0003093 regulation of glomerular filtration(GO:0003093) caveola assembly(GO:0070836)
0.0 0.4 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.4 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.0 GO:0033270 paranode region of axon(GO:0033270)
0.3 0.9 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.4 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.1 0.3 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.2 GO:0005652 nuclear lamina(GO:0005652)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 1.0 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 1.0 GO:0045545 syndecan binding(GO:0045545)
0.1 1.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 0.9 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.6 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.5 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.5 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.4 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.2 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 0.5 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.4 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.2 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition