Motif ID: Foxo6

Z-value: 0.635


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_120287349-0.532.5e-02Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 82 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12027958 2.063 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr6_-_23248264 2.005 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_51987139 1.519 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4
chr5_+_110330697 1.416 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr19_-_45742873 1.397 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chrX_+_106920618 1.346 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chrX_-_163761323 1.239 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr17_-_31277327 1.196 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr1_+_110099295 1.186 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr5_-_99037035 1.091 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr4_+_134510999 1.025 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chrX_-_8193387 1.025 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr5_+_7179299 0.984 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr1_+_74391479 0.973 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr14_-_47418407 0.934 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr7_+_28808795 0.880 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr5_-_117389029 0.873 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chr17_-_24696147 0.830 ENSMUST00000046839.8
 Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chrY_-_6681243 0.803 ENSMUST00000115940.1
 Gm21719
predicted gene, 21719
chrX_+_134585644 0.779 ENSMUST00000113211.1
 Rpl36a
ribosomal protein L36A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 2.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 1.4 GO:0045004 DNA replication proofreading(GO:0045004)
0.5 1.4 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1 1.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 1.2 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 1.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 1.1 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.0 1.0 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 1.0 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1 0.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.9 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 0.8 GO:0097421 liver regeneration(GO:0097421)
0.0 0.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 0.6 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 0.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.4 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.4 GO:0050957 equilibrioception(GO:0050957)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.7 GO:0000922 spindle pole(GO:0000922)
0.3 1.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.2 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0097444 spine apparatus(GO:0097444)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 1.4 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.5 1.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.2 GO:0019843 rRNA binding(GO:0019843)
0.3 1.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.3 1.0 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 1.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.9 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 0.8 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.6 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 0.4 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 0.3 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_IGF1_PATHWAY IGF1 pathway
0.1 1.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.4 PID_FGF_PATHWAY FGF signaling pathway
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.9 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 2.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 1.4 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds