Motif ID: Rfx2_Rfx7
Z-value: 0.981
Transcription factors associated with Rfx2_Rfx7:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rfx2 | ENSMUSG00000024206.8 | Rfx2 |
| Rfx7 | ENSMUSG00000037674.9 | Rfx7 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rfx2 | mm10_v2_chr17_-_56830916_56831008 | -0.46 | 5.3e-02 | Click! |
| Rfx7 | mm10_v2_chr9_+_72532609_72532828 | -0.35 | 1.6e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 97 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.1 | 1.7 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.3 | 1.3 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
| 0.1 | 1.3 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.4 | 1.2 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.1 | 1.2 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 1.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 1.1 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.1 | 1.0 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.1 | 1.0 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.1 | 1.0 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 1.0 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 1.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 0.9 | GO:2000832 | androgen secretion(GO:0035935) testosterone secretion(GO:0035936) positive regulation of apoptotic DNA fragmentation(GO:1902512) negative regulation of steroid hormone secretion(GO:2000832) regulation of androgen secretion(GO:2000834) regulation of testosterone secretion(GO:2000843) |
| 0.2 | 0.9 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.2 | 0.9 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.1 | 0.9 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.2 | 0.8 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
| 0.2 | 0.8 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.1 | 0.8 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 51 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.8 | GO:0001726 | ruffle(GO:0001726) |
| 0.1 | 1.7 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.3 | 1.3 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 0.0 | 1.3 | GO:0042641 | actomyosin(GO:0042641) |
| 0.1 | 1.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 1.1 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 1.1 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.3 | 1.0 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.2 | 1.0 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.2 | 0.9 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.2 | 0.9 | GO:0000235 | astral microtubule(GO:0000235) |
| 0.0 | 0.9 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.3 | 0.8 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.1 | 0.8 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.0 | 0.8 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.2 | 0.5 | GO:0098842 | postsynaptic early endosome(GO:0098842) |
| 0.1 | 0.5 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 0.5 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 0.5 | GO:0031209 | SCAR complex(GO:0031209) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 63 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 1.7 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.2 | 1.3 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.1 | 1.2 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 1.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 1.0 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.2 | 1.0 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.2 | 1.0 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 1.0 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 1.0 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.2 | 0.9 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.1 | 0.8 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.2 | 0.7 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 0.7 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.1 | 0.7 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.0 | 0.7 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 0.6 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.1 | 0.6 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.5 | GO:0001847 | opsonin receptor activity(GO:0001847) |
Gene overrepresentation in C2:CP category:
Showing 1 to 12 of 12 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.2 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.1 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 1.1 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.8 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.8 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.7 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.7 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.6 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.4 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.4 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.2 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 22 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 1.4 | REACTOME_REGULATION_OF_INSULIN_SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.0 | 1.3 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.1 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 1.0 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.0 | REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.1 | 0.9 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.6 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.5 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 0.4 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.4 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.4 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.4 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.4 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.3 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.3 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 0.2 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
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