Motif ID: Pbx1_Pbx3
Z-value: 1.307
Transcription factors associated with Pbx1_Pbx3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pbx1 | ENSMUSG00000052534.9 | Pbx1 |
| Pbx3 | ENSMUSG00000038718.9 | Pbx3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pbx1 | mm10_v2_chr1_-_168431896_168431905 | -0.39 | 1.1e-01 | Click! |
| Pbx3 | mm10_v2_chr2_-_34372004_34372044 | 0.34 | 1.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.6 | GO:0044413 | regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 1.2 | 2.5 | GO:0097168 | mesenchymal stem cell proliferation(GO:0097168) |
| 1.2 | 3.6 | GO:0097402 | neuroblast migration(GO:0097402) |
| 1.0 | 5.1 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
| 1.0 | 3.0 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
| 0.7 | 2.9 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.7 | 4.1 | GO:0072049 | comma-shaped body morphogenesis(GO:0072049) |
| 0.6 | 1.7 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.6 | 4.5 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.5 | 2.7 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.4 | 2.6 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.4 | 1.1 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.3 | 1.0 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.3 | 1.0 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.3 | 1.0 | GO:0030862 | neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862) |
| 0.3 | 0.9 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
| 0.3 | 0.9 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.3 | 0.9 | GO:0060023 | soft palate development(GO:0060023) |
| 0.3 | 0.8 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.3 | 1.1 | GO:0001887 | selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259) |
| 0.2 | 0.7 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 0.2 | 1.2 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
| 0.2 | 0.7 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.2 | 1.1 | GO:0021764 | amygdala development(GO:0021764) |
| 0.2 | 0.7 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.2 | 1.4 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.2 | 0.4 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 0.2 | 0.6 | GO:0072554 | blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.2 | 0.9 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.2 | 0.5 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.2 | 3.7 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.2 | 1.8 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.2 | 3.0 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.2 | 1.5 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.2 | 2.7 | GO:0007530 | sex determination(GO:0007530) |
| 0.1 | 0.1 | GO:0044830 | modulation by host of viral RNA genome replication(GO:0044830) |
| 0.1 | 2.2 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.1 | 0.4 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.1 | 1.1 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.1 | 0.5 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.1 | 0.5 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.1 | 1.0 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.1 | 0.5 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.1 | 1.3 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.1 | 0.6 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.1 | 0.3 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
| 0.1 | 0.7 | GO:0090005 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) |
| 0.1 | 0.4 | GO:0001692 | histamine metabolic process(GO:0001692) histidine metabolic process(GO:0006547) imidazole-containing compound catabolic process(GO:0052805) |
| 0.1 | 0.4 | GO:1903998 | regulation of eating behavior(GO:1903998) |
| 0.1 | 0.5 | GO:1903232 | melanosome assembly(GO:1903232) |
| 0.1 | 0.7 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.1 | 0.2 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.1 | 0.3 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.1 | 0.5 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.1 | 0.3 | GO:0060066 | oviduct development(GO:0060066) |
| 0.1 | 0.2 | GO:1904580 | quinolinate biosynthetic process(GO:0019805) regulation of intracellular mRNA localization(GO:1904580) |
| 0.1 | 0.2 | GO:0070650 | actin filament bundle distribution(GO:0070650) |
| 0.1 | 0.2 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.1 | 0.8 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 1.3 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.1 | 0.7 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.1 | 0.5 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.1 | 0.9 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.1 | 0.4 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
| 0.1 | 1.3 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.1 | 0.2 | GO:2000334 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 1.1 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
| 0.1 | 0.2 | GO:0060672 | negative regulation of keratinocyte differentiation(GO:0045617) epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.1 | 0.3 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.1 | 0.6 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.1 | 2.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 0.2 | GO:0043686 | co-translational protein modification(GO:0043686) |
| 0.1 | 0.7 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.1 | 0.6 | GO:0030388 | fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 0.6 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.1 | GO:0072086 | specification of loop of Henle identity(GO:0072086) |
| 0.1 | 0.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 0.2 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
| 0.1 | 0.5 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.1 | 0.6 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 0.4 | GO:0015862 | uridine transport(GO:0015862) |
| 0.1 | 0.2 | GO:0070973 | COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.1 | 0.2 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.0 | 0.5 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
| 0.0 | 0.6 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.0 | 0.4 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.0 | 0.9 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.0 | 0.7 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.0 | 0.1 | GO:0048661 | positive regulation of smooth muscle cell proliferation(GO:0048661) |
| 0.0 | 0.6 | GO:0046697 | decidualization(GO:0046697) |
| 0.0 | 0.2 | GO:1904684 | negative regulation of metalloendopeptidase activity(GO:1904684) |
| 0.0 | 0.6 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.6 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 0.0 | 0.2 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.0 | 0.4 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.0 | 0.4 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.0 | 0.6 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.0 | 1.3 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.0 | 0.5 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.0 | 0.1 | GO:0032289 | central nervous system myelin formation(GO:0032289) |
| 0.0 | 0.1 | GO:0071286 | cellular response to magnesium ion(GO:0071286) |
| 0.0 | 1.1 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.0 | 0.1 | GO:0002069 | columnar/cuboidal epithelial cell maturation(GO:0002069) |
| 0.0 | 0.3 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.0 | 0.3 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.0 | 0.4 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.3 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.0 | 0.3 | GO:1901339 | regulation of store-operated calcium channel activity(GO:1901339) |
| 0.0 | 0.4 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 0.1 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
| 0.0 | 0.2 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.0 | 0.1 | GO:0018377 | N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377) |
| 0.0 | 0.3 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
| 0.0 | 0.2 | GO:0006573 | valine metabolic process(GO:0006573) |
| 0.0 | 0.7 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.0 | 0.1 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.0 | 0.3 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) |
| 0.0 | 0.0 | GO:0034140 | negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) |
| 0.0 | 0.1 | GO:1903406 | regulation of sodium:potassium-exchanging ATPase activity(GO:1903406) |
| 0.0 | 0.1 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.0 | 0.1 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.0 | 0.3 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.0 | 0.1 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.0 | 1.0 | GO:1904894 | positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894) |
| 0.0 | 0.2 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.0 | 0.1 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.0 | 0.2 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.2 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 0.1 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 0.0 | 0.2 | GO:0070828 | heterochromatin organization(GO:0070828) |
| 0.0 | 2.2 | GO:0001843 | neural tube closure(GO:0001843) tube closure(GO:0060606) |
| 0.0 | 1.6 | GO:0001942 | hair follicle development(GO:0001942) |
| 0.0 | 2.0 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.0 | 0.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 0.6 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 0.5 | GO:0006739 | NADP metabolic process(GO:0006739) |
| 0.0 | 0.1 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 0.0 | 0.2 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.0 | 0.2 | GO:0031290 | retinal ganglion cell axon guidance(GO:0031290) |
| 0.0 | 0.2 | GO:0060135 | maternal process involved in female pregnancy(GO:0060135) |
| 0.0 | 0.1 | GO:0032366 | intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367) |
| 0.0 | 0.3 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
| 0.0 | 0.7 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 1.4 | GO:0030218 | erythrocyte differentiation(GO:0030218) |
| 0.0 | 0.5 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.6 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.8 | 2.3 | GO:0000801 | central element(GO:0000801) |
| 0.5 | 1.5 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
| 0.5 | 4.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.4 | 1.1 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.3 | 1.4 | GO:0008623 | CHRAC(GO:0008623) |
| 0.3 | 4.2 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.3 | 1.3 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
| 0.2 | 1.4 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.2 | 1.2 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.2 | 1.0 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.2 | 0.5 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.2 | 1.3 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.2 | 0.6 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.2 | 0.9 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.1 | 0.7 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.6 | GO:0016234 | inclusion body(GO:0016234) |
| 0.1 | 0.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 0.7 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 1.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 0.7 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 3.0 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.3 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 0.4 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 1.1 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.2 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.0 | 0.9 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 0.6 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.3 | GO:0043219 | lateral loop(GO:0043219) |
| 0.0 | 0.2 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.2 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 0.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.2 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.0 | 0.4 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 1.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 1.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.4 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.3 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 0.2 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 0.1 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 0.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.1 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 0.0 | 6.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.7 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 5.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.2 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.0 | 1.4 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 0.1 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.0 | 1.2 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 2.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.9 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 0.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.3 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.3 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.1 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 1.0 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.6 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.9 | 2.7 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.6 | 1.7 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.4 | 2.5 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.2 | 1.0 | GO:0019808 | polyamine binding(GO:0019808) |
| 0.2 | 4.9 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.2 | 1.1 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.2 | 4.3 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.2 | 3.0 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.2 | 1.0 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.2 | 0.5 | GO:0035651 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
| 0.2 | 0.6 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.2 | 0.6 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 0.6 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
| 0.1 | 0.6 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 0.9 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 0.5 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.1 | 1.8 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.1 | 4.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.8 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 1.0 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 0.7 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.1 | 0.4 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.1 | 1.0 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 1.3 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 0.6 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 0.5 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.1 | 3.0 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 3.0 | GO:0043394 | proteoglycan binding(GO:0043394) |
| 0.1 | 1.4 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 0.5 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 0.2 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.1 | 0.2 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 0.6 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 0.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 0.6 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.1 | 1.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.5 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.1 | 3.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 1.1 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 1.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 2.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.2 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.1 | 6.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 0.4 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 0.2 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.1 | 1.0 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.0 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.4 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.0 | 0.7 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 1.0 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 3.7 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.3 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 0.3 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.0 | 0.7 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.2 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.0 | 0.2 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.0 | 0.6 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 12.9 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 0.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.2 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 0.2 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.0 | 0.2 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.0 | 1.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 1.1 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 1.7 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.5 | GO:1990841 | peroxisome proliferator activated receptor binding(GO:0042975) promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.0 | 0.1 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 0.4 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.1 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.0 | 0.9 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.1 | GO:0032450 | alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450) |
| 0.0 | 0.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.6 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.1 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.1 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 0.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 0.6 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.0 | 0.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.3 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.2 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.0 | 0.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.4 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 0.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.3 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.2 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.4 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.1 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 1.5 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 9.1 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 4.1 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 1.1 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 2.4 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.0 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 3.8 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.0 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.9 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.3 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.0 | 1.5 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.6 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.0 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.5 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.4 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.7 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.3 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.6 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.0 | 1.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.1 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 4.2 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 4.9 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 3.0 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 2.5 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 2.7 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 4.7 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 1.5 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 1.0 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 0.9 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 2.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 2.0 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.3 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.0 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.2 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 0.6 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 2.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.7 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 3.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.6 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.5 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.6 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.5 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.7 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.3 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.4 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.4 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.6 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 0.3 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 1.9 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 0.6 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.1 | REACTOME_MRNA_CAPPING | Genes involved in mRNA Capping |
| 0.0 | 0.8 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.7 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.2 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.4 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 1.3 | REACTOME_DIABETES_PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 0.3 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
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