Motif ID: Pbx1_Pbx3

Z-value: 1.307

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx1mm10_v2_chr1_-_168431896_168431905-0.391.1e-01Click!
Pbx3mm10_v2_chr2_-_34372004_343720440.341.7e-01Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_63711969 4.625 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr17_-_70853482 2.952 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr13_+_15463837 2.951 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr14_-_48667508 2.865 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chrX_-_60893430 2.721 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr3_-_8667033 2.687 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr11_-_22001605 2.686 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr3_+_37639985 2.659 ENSMUST00000108107.1
 Spry1
sprouty homolog 1 (Drosophila)
chrX_+_58030622 2.626 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr17_-_85688252 2.462 ENSMUST00000024947.7
ENSMUST00000163568.2
 Six2

sine oculis-related homeobox 2

chrX_-_52165252 2.456 ENSMUST00000033450.2
 Gpc4
glypican 4
chr3_+_37639945 2.448 ENSMUST00000108109.1
ENSMUST00000038569.1
 Spry1

sprouty homolog 1 (Drosophila)

chr14_-_61037937 2.324 ENSMUST00000111236.2
 Tnfrsf19
tumor necrosis factor receptor superfamily, member 19
chr19_-_9899450 2.295 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr4_-_3938354 2.227 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr17_+_85620816 2.181 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr14_-_122465677 1.993 ENSMUST00000039118.6
 Zic5
zinc finger protein of the cerebellum 5
chr8_-_116732991 1.908 ENSMUST00000109102.2
 Cdyl2
chromodomain protein, Y chromosome-like 2
chr1_-_183147461 1.826 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr11_-_19018956 1.779 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
1.5 4.6 GO:0044413 regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.6 4.5 GO:0048625 myoblast fate commitment(GO:0048625)
0.7 4.1 GO:0072049 comma-shaped body morphogenesis(GO:0072049)
0.2 3.7 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
1.2 3.6 GO:0097402 neuroblast migration(GO:0097402)
1.0 3.0 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.2 3.0 GO:0038092 nodal signaling pathway(GO:0038092)
0.7 2.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 2.7 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.2 2.7 GO:0007530 sex determination(GO:0007530)
0.4 2.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.2 2.5 GO:0097168 mesenchymal stem cell proliferation(GO:0097168)
0.1 2.2 GO:0060736 prostate gland growth(GO:0060736)
0.1 2.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.2 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0 2.0 GO:0000910 cytokinesis(GO:0000910)
0.2 1.8 GO:0060539 diaphragm development(GO:0060539)
0.6 1.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 1.6 GO:0001942 hair follicle development(GO:0001942)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.7 GO:0016607 nuclear speck(GO:0016607)
0.9 4.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.5 4.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 4.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 3.0 GO:0016592 mediator complex(GO:0016592)
0.8 2.3 GO:0000801 central element(GO:0000801)
0.0 2.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.9 GO:0005875 microtubule associated complex(GO:0005875)
0.5 1.5 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.3 1.4 GO:0008623 CHRAC(GO:0008623)
0.2 1.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 1.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.4 GO:0030496 midbody(GO:0030496)
0.3 1.3 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 1.3 GO:0072687 meiotic spindle(GO:0072687)
0.1 1.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.2 1.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 1.2 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 6.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 4.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.9 4.6 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 4.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 4.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 3.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 3.0 GO:0070410 co-SMAD binding(GO:0070410)
0.1 3.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.0 GO:0043394 proteoglycan binding(GO:0043394)
0.1 3.0 GO:0070888 E-box binding(GO:0070888)
0.9 2.7 GO:0035939 microsatellite binding(GO:0035939)
0.4 2.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.8 GO:0015197 peptide transporter activity(GO:0015197)
0.6 1.7 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 1.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.4 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 5.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 4.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 3.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 3.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.5 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_ATM_PATHWAY ATM pathway
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 4.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 4.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.2 4.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 2.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 2.0 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.9 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 1.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.3 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.0 1.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.9 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac