Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 1.027

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mlxmm10_v2_chr11_+_101087277_101087323-0.736.4e-04Click!
Arntlmm10_v2_chr7_+_113207465_113207595-0.581.3e-02Click!
Tfe3mm10_v2_chrX_+_7762652_7762695-0.371.3e-01Click!
Mlxiplmm10_v2_chr5_+_135106881_135106918-0.077.9e-01Click!
Mitfmm10_v2_chr6_+_97807014_97807067-0.009.9e-01Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_127063599 5.100 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr19_-_4201591 4.601 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr10_+_127063527 4.547 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr11_+_70000578 3.907 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr3_+_137864573 3.328 ENSMUST00000174561.1
ENSMUST00000173790.1
 H2afz

H2A histone family, member Z

chr10_-_128923948 3.136 ENSMUST00000131271.1
 Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chr5_+_99979061 3.104 ENSMUST00000046721.1
 4930524J08Rik
RIKEN cDNA 4930524J08 gene
chr7_-_45466894 2.977 ENSMUST00000033093.8
 Bax
BCL2-associated X protein
chr2_+_121449362 2.974 ENSMUST00000110615.1
ENSMUST00000099475.5
 Serf2

small EDRK-rich factor 2

chr17_-_26939464 2.846 ENSMUST00000025027.8
ENSMUST00000114935.1
 Cuta

cutA divalent cation tolerance homolog (E. coli)

chr3_+_137864487 2.843 ENSMUST00000041045.7
 H2afz
H2A histone family, member Z
chr5_-_137314175 2.841 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr3_+_90052814 2.718 ENSMUST00000160640.1
ENSMUST00000029552.6
ENSMUST00000162114.1
ENSMUST00000068798.6
 4933434E20Rik



RIKEN cDNA 4933434E20 gene



chrX_-_134600976 2.682 ENSMUST00000033621.6
 Gla
galactosidase, alpha
chr6_+_108660616 2.523 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr10_-_128923439 2.506 ENSMUST00000153731.1
ENSMUST00000026405.3
 Bloc1s1

biogenesis of lysosome-related organelles complex-1, subunit 1

chr10_-_128922888 2.490 ENSMUST00000135161.1
 Rdh5
retinol dehydrogenase 5
chrX_+_134601179 2.443 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
 Hnrnph2


heterogeneous nuclear ribonucleoprotein H2


chr11_+_69935894 2.267 ENSMUST00000149194.1
 Ybx2
Y box protein 2
chr10_+_41519493 2.243 ENSMUST00000019962.8
 Cd164
CD164 antigen

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 551 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 9.6 GO:0010288 response to lead ion(GO:0010288)
0.3 6.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.3 6.1 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 6.0 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 4.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 4.1 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.1 4.1 GO:0048255 mRNA stabilization(GO:0048255)
0.8 3.9 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.6 3.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 3.6 GO:0007035 vacuolar acidification(GO:0007035)
0.4 3.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.4 3.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)
1.0 3.0 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.1 3.0 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.9 2.8 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.9 2.7 GO:0046032 ADP catabolic process(GO:0046032)
0.0 2.7 GO:1904591 positive regulation of protein import(GO:1904591)
0.4 2.6 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.3 2.5 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.8 2.4 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 242 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 9.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.9 6.1 GO:0001740 Barr body(GO:0001740)
0.0 6.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 5.6 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 5.6 GO:0016604 nuclear body(GO:0016604)
0.1 5.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.8 4.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 3.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 3.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.7 GO:0005844 polysome(GO:0005844)
0.1 3.6 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.2 3.5 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.2 3.4 GO:0030914 STAGA complex(GO:0030914)
0.1 3.2 GO:0016235 aggresome(GO:0016235)
0.1 3.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.7 3.0 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.3 3.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
1.0 2.9 GO:0033186 CAF-1 complex(GO:0033186)
0.0 2.9 GO:0031012 extracellular matrix(GO:0031012)
0.4 2.7 GO:0033503 HULC complex(GO:0033503)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 343 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.2 GO:0030332 cyclin binding(GO:0030332)
0.1 9.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 8.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.2 4.6 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 4.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 4.5 GO:0045182 translation regulator activity(GO:0045182)
0.4 4.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 4.0 GO:0005109 frizzled binding(GO:0005109)
0.1 4.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 3.8 GO:0050699 WW domain binding(GO:0050699)
0.5 3.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.5 3.1 GO:0043426 MRF binding(GO:0043426)
0.3 3.0 GO:0051434 BH3 domain binding(GO:0051434)
0.4 2.9 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 2.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.4 2.7 GO:0016936 galactoside binding(GO:0016936)
0.3 2.7 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.2 2.7 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 2.7 GO:0005507 copper ion binding(GO:0005507)
0.4 2.6 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 10.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 7.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 5.5 PID_ATR_PATHWAY ATR signaling pathway
0.1 5.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 5.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 5.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.2 4.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 4.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 3.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 2.5 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 2.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 2.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 1.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.4 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 11.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 9.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 8.4 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 8.1 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.2 6.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 6.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.2 5.0 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 4.9 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 3.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 3.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.8 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 2.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.5 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 2.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 2.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 2.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 2.1 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway