Motif ID: Xbp1_Creb3l1

Z-value: 0.719

Transcription factors associated with Xbp1_Creb3l1:

Gene SymbolEntrez IDGene Name
Creb3l1 ENSMUSG00000027230.9 Creb3l1
Xbp1 ENSMUSG00000020484.12 Xbp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3l1mm10_v2_chr2_-_92024502_92024529-0.312.1e-01Click!
Xbp1mm10_v2_chr11_+_5520652_5520659-0.223.7e-01Click!


Activity profile for motif Xbp1_Creb3l1.

activity profile for motif Xbp1_Creb3l1


Sorted Z-values histogram for motif Xbp1_Creb3l1

Sorted Z-values for motif Xbp1_Creb3l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Xbp1_Creb3l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 191 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_45092130 3.364 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092198 2.924 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
 Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr5_-_135251209 2.232 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr15_+_79516396 2.083 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr7_-_45091713 2.061 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr2_-_105399286 1.730 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr13_-_38528412 1.125 ENSMUST00000035988.8
 Txndc5
thioredoxin domain containing 5
chr3_+_93520473 1.044 ENSMUST00000029515.4
 S100a11
S100 calcium binding protein A11 (calgizzarin)
chr6_-_54593139 1.013 ENSMUST00000046520.6
 Fkbp14
FK506 binding protein 14
chr1_-_163313661 0.964 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
 Prrx1


paired related homeobox 1


chr11_-_116274102 0.771 ENSMUST00000106425.3
 Srp68
signal recognition particle 68
chr11_-_116274197 0.758 ENSMUST00000021133.9
 Srp68
signal recognition particle 68
chr4_+_47474652 0.757 ENSMUST00000065678.5
ENSMUST00000137461.1
ENSMUST00000125622.1
 Sec61b


Sec61 beta subunit


chr5_+_120431770 0.687 ENSMUST00000031591.7
 Lhx5
LIM homeobox protein 5
chr5_-_149053038 0.653 ENSMUST00000085546.6
 Hmgb1
high mobility group box 1
chr10_-_84533884 0.650 ENSMUST00000053871.3
 Ckap4
cytoskeleton-associated protein 4
chr10_+_41519493 0.638 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr6_-_82774448 0.636 ENSMUST00000000642.4
 Hk2
hexokinase 2
chr7_-_144939823 0.632 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr2_+_80315461 0.613 ENSMUST00000028392.7
 Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.7 2.2 GO:1990523 bone regeneration(GO:1990523)
0.2 2.0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.1 GO:0043277 apoptotic cell clearance(GO:0043277)
0.1 1.0 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.9 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.1 0.9 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.9 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.8 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.8 GO:0009311 oligosaccharide metabolic process(GO:0009311)
0.2 0.7 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.7 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 0.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 0.6 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.6 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.1 0.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 0.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.6 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.6 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 1.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.1 0.9 GO:0042589 zymogen granule membrane(GO:0042589)
0.3 0.8 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.6 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.3 GO:0070939 Dsl1p complex(GO:0070939)
0.1 0.3 GO:0097487 multivesicular body membrane(GO:0032585) multivesicular body, internal vesicle(GO:0097487)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.2 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 11.3 GO:0005509 calcium ion binding(GO:0005509)
0.6 2.3 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 1.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 1.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.1 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.0 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 0.8 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 0.8 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.2 0.7 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.2 0.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.6 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.6 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 0.8 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.5 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 2.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.1 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 1.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.9 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.7 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis