Motif ID: Sox6_Sox9
Z-value: 0.828
Transcription factors associated with Sox6_Sox9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Sox6 | ENSMUSG00000051910.7 | Sox6 |
| Sox9 | ENSMUSG00000000567.5 | Sox9 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox9 | mm10_v2_chr11_+_112782182_112782248 | -0.44 | 6.6e-02 | Click! |
| Sox6 | mm10_v2_chr7_-_115824699_115824752 | 0.26 | 2.9e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.4 | GO:0042560 | 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560) |
| 0.6 | 2.3 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.6 | 1.7 | GO:0021837 | motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465) |
| 0.5 | 5.0 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
| 0.5 | 1.5 | GO:1901079 | positive regulation of relaxation of muscle(GO:1901079) |
| 0.5 | 1.8 | GO:0032289 | central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912) |
| 0.4 | 1.3 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.4 | 2.1 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.4 | 1.1 | GO:0043379 | memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.3 | 2.0 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.3 | 1.8 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.3 | 2.1 | GO:0044838 | cell quiescence(GO:0044838) |
| 0.3 | 2.3 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.3 | 1.2 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.3 | 0.8 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.3 | 1.4 | GO:1903587 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
| 0.3 | 1.1 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.3 | 4.6 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.3 | 0.8 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.2 | 0.7 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.2 | 4.1 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.2 | 0.7 | GO:2000616 | negative regulation of histone H3-K9 acetylation(GO:2000616) |
| 0.2 | 1.3 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.2 | 2.2 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.2 | 0.9 | GO:0031161 | phosphatidylinositol catabolic process(GO:0031161) |
| 0.2 | 1.5 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.2 | 2.3 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.2 | 1.2 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.2 | 0.5 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) |
| 0.2 | 0.5 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.2 | 0.6 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.2 | 0.9 | GO:1904953 | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953) |
| 0.2 | 0.9 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 2.8 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.1 | 1.9 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.1 | 1.0 | GO:0060903 | positive regulation of meiosis I(GO:0060903) |
| 0.1 | 0.7 | GO:0060178 | regulation of exocyst localization(GO:0060178) |
| 0.1 | 0.6 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.1 | 0.6 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
| 0.1 | 0.6 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.1 | 0.3 | GO:0090649 | response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 0.1 | 1.1 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.1 | 0.5 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.1 | 1.0 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.1 | 1.0 | GO:0045075 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 0.1 | 0.5 | GO:0072362 | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362) |
| 0.1 | 0.6 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 1.1 | GO:0098907 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907) |
| 0.1 | 0.4 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.1 | 0.4 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.1 | 1.7 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.1 | 0.7 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.1 | 0.9 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 0.5 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.1 | 0.8 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.1 | 1.2 | GO:0032808 | lacrimal gland development(GO:0032808) |
| 0.1 | 0.3 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 0.1 | 0.6 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.1 | 1.3 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.1 | 0.4 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.1 | 0.8 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) |
| 0.1 | 0.8 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.1 | 0.3 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.1 | 1.0 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.1 | 0.3 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.1 | 0.3 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.1 | 1.0 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.1 | 0.3 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.1 | 0.4 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.1 | 0.5 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.1 | 0.8 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.1 | 0.4 | GO:0050912 | detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
| 0.1 | 1.3 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.1 | 0.5 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.1 | 1.0 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.1 | 0.3 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.1 | 0.4 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.1 | 1.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.6 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.1 | 0.5 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.1 | 0.6 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.1 | 1.6 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.1 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.1 | 0.5 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 1.7 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.1 | 2.0 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 3.6 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.1 | 0.2 | GO:0021546 | rhombomere development(GO:0021546) |
| 0.1 | 1.2 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 0.4 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
| 0.1 | 1.3 | GO:0006308 | DNA catabolic process(GO:0006308) |
| 0.0 | 0.2 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 0.0 | 0.4 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.0 | 0.2 | GO:1904684 | negative regulation of metalloendopeptidase activity(GO:1904684) |
| 0.0 | 0.3 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.0 | 0.2 | GO:0016128 | phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129) |
| 0.0 | 0.6 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.0 | 2.7 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 0.0 | 0.2 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.0 | 0.2 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 0.2 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.0 | 0.3 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 0.1 | GO:0071544 | diphosphoinositol polyphosphate catabolic process(GO:0071544) |
| 0.0 | 0.2 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 5.3 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.4 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.0 | 0.2 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.0 | 0.2 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
| 0.0 | 0.5 | GO:0048505 | regulation of timing of cell differentiation(GO:0048505) |
| 0.0 | 1.2 | GO:0007254 | JNK cascade(GO:0007254) |
| 0.0 | 0.2 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.0 | 0.3 | GO:0051923 | sulfation(GO:0051923) |
| 0.0 | 0.2 | GO:1900095 | regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.0 | 0.2 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.0 | 0.8 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 0.2 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.0 | 0.1 | GO:0003310 | pancreatic A cell differentiation(GO:0003310) |
| 0.0 | 0.3 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.0 | 0.6 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.0 | 0.1 | GO:1902527 | positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527) |
| 0.0 | 0.2 | GO:0055091 | phospholipid homeostasis(GO:0055091) |
| 0.0 | 0.6 | GO:2000772 | regulation of cellular senescence(GO:2000772) |
| 0.0 | 0.2 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
| 0.0 | 0.6 | GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433) |
| 0.0 | 0.7 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 0.2 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.0 | 0.3 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) |
| 0.0 | 0.1 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.0 | 0.3 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.0 | 1.3 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 0.4 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.0 | 0.3 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.0 | 0.8 | GO:0040018 | positive regulation of multicellular organism growth(GO:0040018) |
| 0.0 | 2.8 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 0.1 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.0 | 2.9 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.0 | 0.7 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.3 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.0 | 0.2 | GO:0033129 | positive regulation of histone phosphorylation(GO:0033129) |
| 0.0 | 0.1 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
| 0.0 | 0.2 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.0 | 0.4 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.5 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.0 | 2.3 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.3 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.0 | 0.2 | GO:0032620 | interleukin-17 production(GO:0032620) |
| 0.0 | 0.6 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 2.0 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 0.2 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 0.3 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.1 | GO:0010587 | miRNA catabolic process(GO:0010587) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.6 | GO:0044307 | dendritic branch(GO:0044307) |
| 1.1 | 3.2 | GO:0030934 | collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934) |
| 0.6 | 5.0 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.4 | 1.5 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.4 | 1.8 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.3 | 1.4 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
| 0.3 | 1.2 | GO:0031673 | H zone(GO:0031673) |
| 0.3 | 2.7 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.2 | 0.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.2 | 0.6 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.2 | 1.1 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.1 | 2.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 2.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 1.0 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.4 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.1 | 0.9 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.1 | 0.8 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 0.4 | GO:0008091 | spectrin(GO:0008091) cuticular plate(GO:0032437) |
| 0.1 | 0.6 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 2.2 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 3.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 0.5 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 0.3 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
| 0.0 | 0.8 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 1.3 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.4 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 1.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.7 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.8 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 3.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.6 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 1.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.5 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 1.2 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.4 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 0.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.0 | 0.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.9 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 0.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.3 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 1.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 3.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.3 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.0 | 1.0 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.0 | 0.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 2.0 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 0.3 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.1 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.8 | 2.4 | GO:0016155 | formyltetrahydrofolate dehydrogenase activity(GO:0016155) |
| 0.7 | 2.2 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.5 | 2.0 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.5 | 3.2 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.4 | 4.7 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.3 | 1.2 | GO:0004952 | dopamine neurotransmitter receptor activity(GO:0004952) |
| 0.3 | 0.8 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.2 | 5.0 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.2 | 2.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 0.9 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.2 | 0.8 | GO:0031721 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
| 0.2 | 0.9 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.2 | 0.5 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.2 | 0.9 | GO:0052833 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.2 | 1.5 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.2 | 0.8 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
| 0.2 | 0.6 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
| 0.2 | 0.8 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.1 | 0.6 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.1 | 5.1 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 1.5 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 0.4 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.1 | 1.9 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.1 | 1.0 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.1 | 1.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.1 | 1.3 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.1 | 0.5 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
| 0.1 | 0.5 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.1 | 0.6 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 0.3 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.1 | 0.3 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
| 0.1 | 0.3 | GO:0016880 | acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.1 | 2.1 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.1 | 0.7 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 1.1 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.1 | 0.3 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.1 | 0.4 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.1 | 0.5 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.1 | 0.3 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.1 | 0.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.5 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 1.1 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 0.2 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.1 | 0.5 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.1 | 1.1 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 3.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 1.1 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.1 | 1.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 3.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 0.6 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 0.3 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.0 | 3.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.7 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 0.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.1 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.0 | 0.2 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.0 | 0.9 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.3 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 0.3 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.0 | 1.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.2 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.2 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.0 | 1.7 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 8.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 0.2 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 2.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.1 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.0 | 1.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.2 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.0 | 0.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 0.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.4 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 1.5 | GO:0005267 | potassium channel activity(GO:0005267) |
| 0.0 | 1.0 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.3 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.1 | GO:0000298 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) |
| 0.0 | 0.4 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.8 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 1.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 2.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.1 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.0 | 0.2 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.2 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.6 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.0 | 0.0 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 0.0 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.3 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 2.2 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.9 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.0 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 3.5 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.2 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.9 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 1.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.7 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.9 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.7 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.5 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.9 | PID_AVB3_INTEGRIN_PATHWAY | Integrins in angiogenesis |
| 0.0 | 0.4 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.4 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.1 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.2 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.8 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 0.5 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.2 | 1.7 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.1 | 1.1 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 0.8 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 0.9 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.1 | 2.7 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 4.5 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.8 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 1.1 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 0.2 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 0.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.5 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.3 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.8 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 1.1 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.4 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
| 0.0 | 0.4 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 2.7 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.4 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.7 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 0.7 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 2.8 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 1.6 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.4 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.4 | REACTOME_ARMS_MEDIATED_ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 3.0 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.1 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.6 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.3 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.2 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 0.3 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.0 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.3 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
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