Motif ID: Sox6_Sox9

Z-value: 0.828

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_112782248-0.446.6e-02Click!
Sox6mm10_v2_chr7_-_115824699_1158247520.262.9e-01Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_29528382 4.743 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr17_+_55445550 3.293 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr9_+_27790947 2.973 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr5_+_66968559 2.943 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr5_+_3928033 2.850 ENSMUST00000143365.1
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr9_-_29411736 2.757 ENSMUST00000115236.1
 Ntm
neurotrimin
chr18_+_37484955 2.523 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr9_-_29412204 2.444 ENSMUST00000115237.1
 Ntm
neurotrimin
chr10_-_83534130 2.353 ENSMUST00000020497.7
 Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr10_+_69534039 2.328 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr17_-_68004075 2.282 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr1_-_64122256 2.190 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr10_-_29144194 2.182 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr1_-_56972437 2.158 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr11_+_67586520 1.918 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr6_+_86404336 1.906 ENSMUST00000113713.2
ENSMUST00000113708.1
 Tia1

cytotoxic granule-associated RNA binding protein 1

chr11_+_67586675 1.852 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr2_-_36104060 1.849 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr10_+_29143996 1.813 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr7_+_96210107 1.804 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.3 GO:0007416 synapse assembly(GO:0007416)
0.5 5.0 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.3 4.6 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.2 4.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 3.6 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 2.9 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.1 2.8 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 2.8 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 2.7 GO:0016574 histone ubiquitination(GO:0016574)
0.8 2.4 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.6 2.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 2.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 2.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 2.3 GO:0008360 regulation of cell shape(GO:0008360)
0.2 2.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 2.1 GO:0046684 response to pyrethroid(GO:0046684)
0.3 2.1 GO:0044838 cell quiescence(GO:0044838)
0.3 2.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 2.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 2.0 GO:0031032 actomyosin structure organization(GO:0031032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 5.0 GO:0097165 nuclear stress granule(GO:0097165)
1.2 4.6 GO:0044307 dendritic branch(GO:0044307)
0.0 3.9 GO:0000139 Golgi membrane(GO:0000139)
0.1 3.5 GO:0005871 kinesin complex(GO:0005871)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
1.1 3.2 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 2.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 2.7 GO:0001739 sex chromatin(GO:0001739)
0.1 2.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 2.2 GO:0043034 costamere(GO:0043034)
0.1 2.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 1.9 GO:0005923 bicellular tight junction(GO:0005923)
0.4 1.8 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 1.7 GO:0030426 growth cone(GO:0030426)
0.4 1.5 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 1.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 1.4 GO:0005593 FACIT collagen trimer(GO:0005593)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0015631 tubulin binding(GO:0015631)
0.1 5.1 GO:0017091 AU-rich element binding(GO:0017091)
0.2 5.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.4 4.7 GO:0050897 cobalt ion binding(GO:0050897)
0.8 4.1 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 3.5 GO:0030507 spectrin binding(GO:0030507)
0.0 3.5 GO:0003777 microtubule motor activity(GO:0003777)
0.5 3.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 3.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.8 2.4 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.0 2.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 2.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.7 2.2 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 2.1 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.5 2.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.9 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 1.8 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 3.5 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 2.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.9 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 0.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.4 PID_ATM_PATHWAY ATM pathway
0.0 0.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.2 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 4.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 3.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.8 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 1.7 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.6 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 1.5 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.1 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 0.9 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 0.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.8 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination