Motif ID: Egr1

Z-value: 3.182


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_348612150.214.1e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 26.373 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr4_-_22488296 10.233 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr5_-_139130159 10.232 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_-_139129662 9.919 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr14_-_33447142 9.259 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
 Mapk8


mitogen-activated protein kinase 8


chr3_+_54156039 9.089 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr11_-_67922136 9.022 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr14_-_102982630 8.926 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr11_-_6065737 8.677 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr4_+_127169131 8.405 ENSMUST00000046659.7
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr7_+_73740277 8.282 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr14_-_30353468 7.632 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr11_+_98348404 7.284 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr7_-_27396542 6.846 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr6_-_126645784 6.680 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr7_-_45370559 6.040 ENSMUST00000003971.7
 Lin7b
lin-7 homolog B (C. elegans)
chr9_+_59750876 5.922 ENSMUST00000136740.1
ENSMUST00000135298.1
ENSMUST00000128341.1
 Myo9a


myosin IXa


chr5_+_137553517 5.906 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr1_-_56969864 5.904 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr3_+_28263205 5.864 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
11.7 35.0 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
1.7 20.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.9 12.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.7 11.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.2 11.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.5 10.2 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 9.8 GO:0016579 protein deubiquitination(GO:0016579)
3.2 9.7 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.7 9.5 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
2.3 9.3 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
1.3 9.3 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 8.0 GO:0006813 potassium ion transport(GO:0006813)
0.2 7.9 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.4 7.8 GO:0006491 N-glycan processing(GO:0006491)
0.5 7.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
2.4 7.3 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.9 7.2 GO:0005513 detection of calcium ion(GO:0005513)
0.4 7.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)
1.1 6.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
2.2 6.7 GO:0050975 sensory perception of touch(GO:0050975)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 33.9 GO:0051233 spindle midzone(GO:0051233)
1.5 20.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 17.5 GO:0034704 calcium channel complex(GO:0034704)
0.3 17.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 17.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 12.0 GO:0055037 recycling endosome(GO:0055037)
0.4 10.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 10.5 GO:0000139 Golgi membrane(GO:0000139)
1.7 10.1 GO:0008091 spectrin(GO:0008091)
1.6 9.7 GO:0044305 calyx of Held(GO:0044305)
0.3 8.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 8.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 8.1 GO:0048786 presynaptic active zone(GO:0048786)
0.5 7.9 GO:1990635 proximal dendrite(GO:1990635)
1.9 7.8 GO:0090537 CERF complex(GO:0090537)
0.8 7.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 7.1 GO:0005769 early endosome(GO:0005769)
0.4 6.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.1 6.3 GO:0005955 calcineurin complex(GO:0005955)
0.9 6.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 36.7 GO:0043274 phospholipase binding(GO:0043274)
1.8 20.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.1 15.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.7 12.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.2 11.8 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 11.4 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.8 10.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.7 9.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
2.3 9.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.6 7.8 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.7 7.8 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 7.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
2.4 7.3 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.2 6.8 GO:0071837 HMG box domain binding(GO:0071837)
0.1 6.8 GO:0030507 spectrin binding(GO:0030507)
0.1 6.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 6.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 6.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 6.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 6.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 33.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 22.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.4 13.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 9.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.2 9.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.6 8.8 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 8.3 PID_LKB1_PATHWAY LKB1 signaling events
0.3 7.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 6.3 PID_ARF6_PATHWAY Arf6 signaling events
0.1 5.7 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.2 5.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.8 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 4.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 4.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.4 PID_INSULIN_PATHWAY Insulin Pathway
0.1 2.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 40.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.9 20.5 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.4 17.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 12.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
1.6 11.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 10.4 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.7 9.8 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 9.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.8 9.1 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 8.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.7 8.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 7.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 6.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 5.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.2 5.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 5.0 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.5 4.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.4 4.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 4.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.4 3.8 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling