Motif ID: Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.371

Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b:

Gene SymbolEntrez IDGene Name
Arx ENSMUSG00000035277.9 Arx
Esx1 ENSMUSG00000023443.7 Esx1
Hoxc4 ENSMUSG00000075394.3 Hoxc4
Otp ENSMUSG00000021685.10 Otp
Phox2b ENSMUSG00000012520.8 Phox2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otpmm10_v2_chr13_+_94875600_94875611-0.331.9e-01Click!
Arxmm10_v2_chrX_+_93286499_932865220.029.4e-01Click!


Activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b.

activity profile for motif Hoxc4_Arx_Otp_Esx1_Phox2b


Sorted Z-values histogram for motif Hoxc4_Arx_Otp_Esx1_Phox2b

Sorted Z-values for motif Hoxc4_Arx_Otp_Esx1_Phox2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_119063429 1.378 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr17_-_48432723 1.041 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr10_-_37138863 0.719 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr2_-_168767136 0.707 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 0.638 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr8_-_21906412 0.629 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr13_-_58354862 0.542 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr4_+_145585166 0.532 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr2_+_20737306 0.528 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr2_-_33718789 0.487 ENSMUST00000130532.1
 9430024E24Rik
RIKEN cDNA 9430024E24 gene
chr10_+_97482350 0.458 ENSMUST00000163448.2
 Dcn
decorin
chrX_-_60893430 0.455 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr4_+_105789869 0.430 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr11_+_59306920 0.401 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr14_+_58893465 0.385 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr11_+_58171648 0.345 ENSMUST00000020820.1
 Mrpl22
mitochondrial ribosomal protein L22
chr6_-_115037824 0.327 ENSMUST00000174848.1
ENSMUST00000032461.5
 Tamm41

TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)

chr2_-_105017015 0.311 ENSMUST00000111110.2
ENSMUST00000028592.5
 Eif3m

eukaryotic translation initiation factor 3, subunit M

chr15_+_16778101 0.307 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr17_+_34969912 0.288 ENSMUST00000173680.1
 Gm20481
predicted gene 20481

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 1.3 GO:0051693 actin filament capping(GO:0051693)
0.3 1.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.7 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.5 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.5 GO:0007530 sex determination(GO:0007530)
0.0 0.4 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.3 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)
0.0 0.3 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.3 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.0 0.3 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.1 0.2 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.1 0.2 GO:0046098 regulation of primitive erythrocyte differentiation(GO:0010725) guanine metabolic process(GO:0046098)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 0.2 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.0 0.2 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.7 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.2 GO:0097422 tubular endosome(GO:0097422)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:0034709 methylosome(GO:0034709)
0.0 0.1 GO:0097413 Lewy body(GO:0097413)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0051015 actin filament binding(GO:0051015)
0.3 1.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 0.2 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.2 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.2 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.1 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.1 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease