Motif ID: Dlx1

Z-value: 1.065


Transcription factors associated with Dlx1:

Gene SymbolEntrez IDGene Name
Dlx1 ENSMUSG00000041911.3 Dlx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx1mm10_v2_chr2_+_71529085_715291100.214.1e-01Click!


Activity profile for motif Dlx1.

activity profile for motif Dlx1


Sorted Z-values histogram for motif Dlx1

Sorted Z-values for motif Dlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_80000292 1.628 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr4_+_102570065 1.620 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr9_+_34904913 1.522 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr5_+_107403496 1.493 ENSMUST00000049146.5
 Ephx4
epoxide hydrolase 4
chr4_+_102589687 1.406 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr3_-_154330543 1.396 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr15_-_67113909 1.373 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr7_-_140154712 1.340 ENSMUST00000059241.7
 Sprn
shadow of prion protein
chr12_+_84069325 1.322 ENSMUST00000046422.4
ENSMUST00000072505.4
 Acot5

acyl-CoA thioesterase 5

chr3_+_121953213 1.285 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr2_-_5676046 1.255 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr1_+_58210397 1.208 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr6_+_8948608 1.205 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr6_-_101377897 1.180 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr8_+_66386292 1.167 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr18_+_23415400 1.156 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr19_-_59076069 1.149 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr10_-_112928974 1.116 ENSMUST00000099276.2
 Atxn7l3b
ataxin 7-like 3B
chr5_+_29195983 1.106 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
 Rnf32




ring finger protein 32




chr10_+_103367748 1.087 ENSMUST00000074204.4
ENSMUST00000179636.1
 Slc6a15

solute carrier family 6 (neurotransmitter transporter), member 15


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 2.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.5 1.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 1.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 1.6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.3 1.5 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 1.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 1.4 GO:0021884 forebrain neuron development(GO:0021884)
0.0 1.4 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.3 1.3 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.3 1.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 1.3 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.4 1.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.4 1.2 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 1.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 1.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 1.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 1.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 1.0 GO:0042541 hemoglobin biosynthetic process(GO:0042541)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.2 GO:0043197 dendritic spine(GO:0043197)
0.1 1.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.6 GO:0042581 specific granule(GO:0042581)
0.0 1.5 GO:0031672 A band(GO:0031672)
0.2 1.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 1.4 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.2 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.1 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.9 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 0.9 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 0.8 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 0.7 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.0 0.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.7 GO:0031594 neuromuscular junction(GO:0031594)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 3.1 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.0 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 1.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.3 1.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 1.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.3 1.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 1.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.1 1.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.1 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.2 1.0 GO:0070330 aromatase activity(GO:0070330)
0.2 1.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.9 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 0.9 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.3 0.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.3 0.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.8 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.9 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 0.5 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.5 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.3 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 1.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.6 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression