Motif ID: Lhx4

Z-value: 0.870


Transcription factors associated with Lhx4:

Gene SymbolEntrez IDGene Name
Lhx4 ENSMUSG00000026468.8 Lhx4



Activity profile for motif Lhx4.

activity profile for motif Lhx4


Sorted Z-values histogram for motif Lhx4

Sorted Z-values for motif Lhx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 193 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 6.056 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr19_+_44493472 5.244 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr17_-_48432723 4.915 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr7_-_49636847 3.986 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr16_-_22161450 3.092 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr1_-_163289214 2.530 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr11_+_59306920 2.511 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr3_+_55782500 2.496 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr17_+_34592248 2.348 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr10_+_37139558 2.218 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr14_+_75455957 2.182 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr10_-_37138863 2.175 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr4_-_97778042 2.143 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_+_153665666 2.099 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr4_-_58499398 2.091 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr9_+_119063429 1.833 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr2_+_20737306 1.815 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr1_+_153665627 1.733 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8
chr2_-_166155272 1.652 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr6_+_7555053 1.642 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 6.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.4 5.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.6 4.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 4.5 GO:0045165 cell fate commitment(GO:0045165)
0.2 4.2 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.8 3.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 3.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 2.8 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 2.6 GO:0051028 mRNA transport(GO:0051028)
0.3 2.5 GO:0048664 neuron fate determination(GO:0048664)
0.1 2.4 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.8 2.3 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.4 2.2 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 2.2 GO:0051764 actin crosslink formation(GO:0051764)
0.5 2.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 1.8 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 1.8 GO:0051693 actin filament capping(GO:0051693)
0.2 1.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 1.6 GO:0051384 response to glucocorticoid(GO:0051384)
0.1 1.5 GO:0071803 positive regulation of podosome assembly(GO:0071803)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 5.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.7 2.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 2.1 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.9 GO:0000776 kinetochore(GO:0000776)
0.1 1.6 GO:0010369 chromocenter(GO:0010369)
0.0 1.5 GO:0002102 podosome(GO:0002102)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.4 GO:0060187 cell pole(GO:0060187)
0.2 1.3 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.0 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 0.8 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.1 0.8 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 0.7 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.7 GO:0097413 Lewy body(GO:0097413)
0.0 0.7 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 GO:0005109 frizzled binding(GO:0005109)
0.1 5.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 5.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.2 4.9 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 3.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.6 3.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 3.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.5 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 2.2 GO:0005080 protein kinase C binding(GO:0005080)
0.3 2.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 1.7 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.4 1.4 GO:0019808 polyamine binding(GO:0019808)
0.1 1.3 GO:0045294 alpha-catenin binding(GO:0045294)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.6 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.4 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 1.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.0 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 PID_PLK1_PATHWAY PLK1 signaling events
0.1 0.7 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.7 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.6 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 7.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.4 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.3 2.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 1.3 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.8 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 0.7 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 0.7 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 0.7 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.1 0.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors