Motif ID: Smad4

Z-value: 1.302


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_73703806-0.272.8e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Showing 1 to 20 of 188 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_103314944 7.130 ENSMUST00000179363.1
 Fam181a
family with sequence similarity 181, member A
chr7_-_70360593 5.055 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr10_-_127534540 4.122 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr17_-_70851710 3.859 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr10_-_92164666 3.599 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr5_+_120431770 3.523 ENSMUST00000031591.7
 Lhx5
LIM homeobox protein 5
chr14_-_54577578 3.427 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr10_+_75589363 3.223 ENSMUST00000072217.2
 Ggt5
gamma-glutamyltransferase 5
chr10_-_42583628 2.907 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr14_+_50944499 2.811 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr11_-_89302545 2.804 ENSMUST00000061728.3
 Nog
noggin
chr13_-_21832194 2.686 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr18_+_57133065 2.686 ENSMUST00000075770.6
 Megf10
multiple EGF-like-domains 10
chr7_+_45216671 2.465 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr14_-_104467984 2.379 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1
chr19_-_40271506 2.346 ENSMUST00000068439.6
 Pdlim1
PDZ and LIM domain 1 (elfin)
chr13_-_102958084 2.298 ENSMUST00000099202.3
ENSMUST00000172264.1
 Mast4

microtubule associated serine/threonine kinase family member 4

chr7_+_45215753 2.239 ENSMUST00000033060.6
ENSMUST00000155313.1
ENSMUST00000107801.1
 Tead2


TEA domain family member 2


chr1_+_153652943 2.226 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr15_+_39076885 2.035 ENSMUST00000067072.3
 Cthrc1
collagen triple helix repeat containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.0 5.1 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.3 4.7 GO:0048368 lateral mesoderm development(GO:0048368)
0.7 4.0 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.2 3.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 3.5 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.5 3.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.8 3.2 GO:0006751 glutathione catabolic process(GO:0006751)
0.6 2.9 GO:0021764 amygdala development(GO:0021764)
0.9 2.8 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.7 2.8 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.3 2.8 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 2.6 GO:0006342 chromatin silencing(GO:0006342)
0.5 2.4 GO:0019230 proprioception(GO:0019230)
0.3 2.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 2.3 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 2.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.5 2.0 GO:0015889 cobalamin transport(GO:0015889)
0.2 2.0 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 2.0 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 4.9 GO:0000790 nuclear chromatin(GO:0000790)
0.1 4.8 GO:0005581 collagen trimer(GO:0005581)
1.6 4.7 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 4.0 GO:0000786 nucleosome(GO:0000786)
0.0 3.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 3.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.8 2.3 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 2.0 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 1.6 GO:0055037 recycling endosome(GO:0055037)
0.1 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.3 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.3 GO:0032039 integrator complex(GO:0032039)
0.0 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.3 1.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.2 GO:0070652 HAUS complex(GO:0070652)
0.0 1.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.4 GO:0042393 histone binding(GO:0042393)
0.5 6.1 GO:0001972 retinoic acid binding(GO:0001972)
0.0 5.3 GO:0005096 GTPase activator activity(GO:0005096)
0.2 4.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 3.9 GO:0070410 co-SMAD binding(GO:0070410)
0.9 3.8 GO:0050436 microfibril binding(GO:0050436)
0.3 3.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.5 3.2 GO:0008242 omega peptidase activity(GO:0008242)
0.1 2.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.9 2.8 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.4 2.7 GO:0001849 complement component C1q binding(GO:0001849)
0.6 2.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 2.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 2.0 GO:0031419 cobalamin binding(GO:0031419)
0.1 2.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 3.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 3.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 0.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 6.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 5.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 4.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 2.8 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 2.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.8 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 2.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 2.1 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 1.7 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.0 1.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 0.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation