Motif ID: Stat4_Stat3_Stat5b

Z-value: 1.055

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_52008210_52008254-0.522.8e-02Click!
Stat3mm10_v2_chr11_-_100939540_100939566-0.465.3e-02Click!
Stat5bmm10_v2_chr11_-_100822525_100822576-0.351.5e-01Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 6.957 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chrX_-_61185558 6.348 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr4_-_64046925 5.245 ENSMUST00000107377.3
 Tnc
tenascin C
chr19_-_5797410 4.194 ENSMUST00000173314.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr17_+_39846958 2.878 ENSMUST00000182010.1
 Gm26924
predicted gene, 26924
chr17_+_26715644 2.623 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr1_+_34005872 2.334 ENSMUST00000182296.1
 Dst
dystonin
chr11_-_77787747 2.089 ENSMUST00000092883.2
 Gm10277
predicted gene 10277
chr12_+_11265867 2.022 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr17_-_68004075 1.953 ENSMUST00000024840.5
 Arhgap28
Rho GTPase activating protein 28
chr12_+_74297474 1.928 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr8_-_105326252 1.876 ENSMUST00000070508.7
 Lrrc29
leucine rich repeat containing 29
chr4_+_148602527 1.838 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr4_-_108031938 1.785 ENSMUST00000106708.1
 Podn
podocan
chr16_-_74411776 1.768 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr16_-_23988852 1.736 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr3_+_96576984 1.702 ENSMUST00000148290.1
 Gm16253
predicted gene 16253
chr5_-_34513892 1.611 ENSMUST00000114359.1
ENSMUST00000030991.7
ENSMUST00000087737.3
 Tnip2


TNFAIP3 interacting protein 2


chr4_-_108032069 1.587 ENSMUST00000106709.2
 Podn
podocan
chr1_+_136624901 1.556 ENSMUST00000047734.8
ENSMUST00000112046.1
 Zfp281

zinc finger protein 281


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.3 5.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.4 4.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.8 4.2 GO:0035063 nuclear speck organization(GO:0035063)
0.1 3.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
1.1 3.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 2.7 GO:0060612 adipose tissue development(GO:0060612)
0.5 2.6 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0 2.2 GO:0017145 stem cell division(GO:0017145)
0.0 2.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 2.0 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 2.0 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.4 1.8 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.2 1.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.8 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.8 GO:0008090 retrograde axonal transport(GO:0008090)
0.6 1.7 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 1.5 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 1.5 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 1.4 GO:0015701 bicarbonate transport(GO:0015701)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 GO:0032279 asymmetric synapse(GO:0032279)
0.3 5.1 GO:0005614 interstitial matrix(GO:0005614)
0.2 4.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 3.2 GO:0030673 axolemma(GO:0030673)
0.6 2.3 GO:0031673 H zone(GO:0031673)
0.1 2.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.7 2.0 GO:0035061 interchromatin granule(GO:0035061)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 1.7 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.3 1.6 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.5 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 1.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.3 GO:0016235 aggresome(GO:0016235)
0.2 1.2 GO:0035976 AP1 complex(GO:0035976)
0.1 1.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.9 5.2 GO:0045545 syndecan binding(GO:0045545)
0.1 4.7 GO:0030507 spectrin binding(GO:0030507)
0.4 3.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 2.4 GO:0005518 collagen binding(GO:0005518)
0.0 2.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 2.2 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.7 GO:0001846 opsonin binding(GO:0001846)
0.1 1.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 1.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 1.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 1.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 1.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 1.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 1.2 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.3 1.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 5.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 4.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.2 1.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 1.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.3 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.9 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 0.8 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.4 PID_VEGFR1_PATHWAY VEGFR1 specific signals

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 4.4 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.9 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.8 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.3 1.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.6 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.4 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.1 1.1 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 0.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol