Motif ID: Grhl1

Z-value: 0.548


Transcription factors associated with Grhl1:

Gene SymbolEntrez IDGene Name
Grhl1 ENSMUSG00000020656.9 Grhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_24572308-0.048.9e-01Click!


Activity profile for motif Grhl1.

activity profile for motif Grhl1


Sorted Z-values histogram for motif Grhl1

Sorted Z-values for motif Grhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Grhl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 53 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_151973387 2.227 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr16_-_26989974 2.081 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr17_+_87635974 1.796 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr2_-_105399286 1.263 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr13_+_8885501 1.094 ENSMUST00000169314.2
 Idi1
isopentenyl-diphosphate delta isomerase
chr2_+_172550761 0.994 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr8_-_71381907 0.943 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr4_+_109676568 0.938 ENSMUST00000102724.4
 Faf1
Fas-associated factor 1
chr10_+_128747850 0.849 ENSMUST00000163377.2
 Wibg
within bgcn homolog (Drosophila)
chr7_+_101321703 0.803 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chrX_+_100730178 0.802 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr10_-_79533750 0.734 ENSMUST00000166804.1
ENSMUST00000063879.5
 Ppap2c

phosphatidic acid phosphatase type 2C

chr6_+_128438757 0.725 ENSMUST00000144745.1
 Gm10069
predicted gene 10069
chr10_-_128565827 0.722 ENSMUST00000131728.1
ENSMUST00000026425.6
 Pa2g4

proliferation-associated 2G4

chr7_+_65693447 0.618 ENSMUST00000143508.1
 Tm2d3
TM2 domain containing 3
chr14_-_79481268 0.595 ENSMUST00000022601.5
 Wbp4
WW domain binding protein 4
chr7_+_65693417 0.571 ENSMUST00000032726.7
ENSMUST00000107495.3
 Tm2d3

TM2 domain containing 3

chr17_-_56005566 0.568 ENSMUST00000043785.6
 Stap2
signal transducing adaptor family member 2
chr14_+_75136326 0.490 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1
chr1_+_135818593 0.487 ENSMUST00000038760.8
 Lad1
ladinin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0006270 DNA replication initiation(GO:0006270)
0.4 1.8 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 1.1 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.3 1.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 0.9 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.9 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.8 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.8 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.6 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.5 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.1 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.0 0.1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.9 GO:0000124 SAGA complex(GO:0000124)
0.1 0.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.5 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)

Gene overrepresentation in molecular_function category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 1.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 1.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.9 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.8 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.7 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.5 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.2 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.2 GO:0097642 calcitonin family receptor activity(GO:0097642)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.5 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis