Motif ID: Hoxb4

Z-value: 0.376


Transcription factors associated with Hoxb4:

Gene SymbolEntrez IDGene Name
Hoxb4 ENSMUSG00000038692.7 Hoxb4



Activity profile for motif Hoxb4.

activity profile for motif Hoxb4


Sorted Z-values histogram for motif Hoxb4

Sorted Z-values for motif Hoxb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_92162753 1.126 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr1_+_10993452 0.715 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr2_-_84775420 0.715 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr6_+_142413441 0.698 ENSMUST00000088263.4
 B230216G23Rik
RIKEN cDNA B230216G23 gene
chr2_-_84775388 0.652 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr17_+_43952999 0.643 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr8_-_105471481 0.624 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr10_-_88605017 0.553 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr4_+_43493345 0.418 ENSMUST00000030181.5
ENSMUST00000107922.2
 Ccdc107

coiled-coil domain containing 107

chr4_-_35845204 0.392 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr15_-_50889691 0.355 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr7_+_30232032 0.321 ENSMUST00000149654.1
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr7_+_30232310 0.305 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chrX_-_8193387 0.300 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr3_-_37125943 0.288 ENSMUST00000029275.5
 Il2
interleukin 2
chr7_+_30231884 0.247 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr18_-_15063560 0.238 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr17_+_86963279 0.211 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr16_+_78930940 0.193 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
 Chodl


chondrolectin


chr2_-_38714491 0.176 ENSMUST00000028084.4
 Nr5a1
nuclear receptor subfamily 5, group A, member 1
chr10_-_89621253 0.170 ENSMUST00000020102.7
 Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr7_-_30232186 0.141 ENSMUST00000006254.5
 Tbcb
tubulin folding cofactor B
chr6_+_116650674 0.125 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr1_-_78968079 0.107 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr18_+_56562443 0.100 ENSMUST00000130163.1
ENSMUST00000132628.1
 Phax

phosphorylated adaptor for RNA export

chr1_-_171222508 0.091 ENSMUST00000005817.2
 Tomm40l
translocase of outer mitochondrial membrane 40 homolog-like (yeast)
chr16_-_94370450 0.090 ENSMUST00000138514.1
 Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr17_+_57279094 0.087 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
 Vav1


vav 1 oncogene


chr1_-_171222435 0.083 ENSMUST00000147246.1
ENSMUST00000111326.1
ENSMUST00000138184.1
 Tomm40l


translocase of outer mitochondrial membrane 40 homolog-like (yeast)


chr16_-_37384940 0.077 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr1_-_45503282 0.070 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr1_+_9545397 0.067 ENSMUST00000072079.7
 Rrs1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr14_+_58070547 0.066 ENSMUST00000165526.1
 Fgf9
fibroblast growth factor 9
chr18_-_56562261 0.059 ENSMUST00000066208.6
ENSMUST00000172734.1
 Aldh7a1

aldehyde dehydrogenase family 7, member A1

chrX_-_49797700 0.057 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1

chr3_-_39359128 0.056 ENSMUST00000056409.2
 Gm9845
predicted pseudogene 9845
chr3_-_54714353 0.032 ENSMUST00000178832.1
 Gm21958
predicted gene, 21958
chr3_-_51277470 0.031 ENSMUST00000108053.2
ENSMUST00000108051.1
 Elf2

E74-like factor 2

chr9_-_60649793 0.019 ENSMUST00000053171.7
 Lrrc49
leucine rich repeat containing 49
chr2_-_119156824 0.003 ENSMUST00000135419.1
ENSMUST00000129351.1
ENSMUST00000139519.1
ENSMUST00000094695.5
 Rmdn3



regulator of microtubule dynamics 3




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.3 0.9 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 0.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.3 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0 0.2 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.0 0.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.1 GO:0051030 snRNA transport(GO:0051030)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.6 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.4 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 1.4 GO:0001848 complement binding(GO:0001848)
0.1 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0015288 porin activity(GO:0015288)
0.0 0.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis