Motif ID: Hmbox1

Z-value: 1.075


Transcription factors associated with Hmbox1:

Gene SymbolEntrez IDGene Name
Hmbox1 ENSMUSG00000021972.8 Hmbox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmbox1mm10_v2_chr14_-_64949838_64949886-0.106.8e-01Click!


Activity profile for motif Hmbox1.

activity profile for motif Hmbox1


Sorted Z-values histogram for motif Hmbox1

Sorted Z-values for motif Hmbox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmbox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 130 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5390387 8.960 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr6_-_23248264 6.596 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_+_100625737 2.119 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr13_-_3893556 2.117 ENSMUST00000099946.4
 Net1
neuroepithelial cell transforming gene 1
chr1_-_163289214 2.081 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr2_-_172043466 2.051 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr7_-_25788635 1.982 ENSMUST00000002677.4
ENSMUST00000085948.4
 Axl

AXL receptor tyrosine kinase

chr3_-_79842662 1.947 ENSMUST00000029568.1
 Tmem144
transmembrane protein 144
chr3_-_100969644 1.856 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chrX_+_169685191 1.710 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr11_-_64436653 1.703 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr15_+_72913357 1.439 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr10_+_22158566 1.431 ENSMUST00000181645.1
ENSMUST00000105522.2
 Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chr10_+_39133981 1.344 ENSMUST00000019991.7
 Tube1
epsilon-tubulin 1
chr4_-_97584612 1.342 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_+_128993224 1.259 ENSMUST00000030583.6
ENSMUST00000102604.4
 Ak2

adenylate kinase 2

chr11_-_94507337 1.248 ENSMUST00000040692.8
 Mycbpap
MYCBP associated protein
chr9_+_35423582 1.155 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr9_-_78368167 1.152 ENSMUST00000071991.5
 Dppa5a
developmental pluripotency associated 5A
chr1_-_152386675 1.091 ENSMUST00000015124.8
 Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
1.1 6.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 2.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 2.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 2.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.2 2.1 GO:0048664 neuron fate determination(GO:0048664)
0.2 2.1 GO:0051451 myoblast migration(GO:0051451)
0.2 2.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.7 2.0 GO:0097350 neutrophil clearance(GO:0097350)
0.0 2.0 GO:0006821 chloride transport(GO:0006821)
0.1 1.9 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 1.9 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.1 1.4 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.2 1.3 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 1.3 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.1 1.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.2 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.1 1.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.0 GO:0007343 egg activation(GO:0007343)
0.1 1.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 9.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 2.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.3 GO:0030496 midbody(GO:0030496)
0.0 2.1 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.0 GO:0043657 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0 1.9 GO:0034707 chloride channel complex(GO:0034707)
0.4 1.4 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.3 1.3 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.1 1.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.0 GO:0030175 filopodium(GO:0030175)
0.2 0.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 0.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.9 GO:0014704 intercalated disc(GO:0014704)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.6 GO:0090544 BAF-type complex(GO:0090544)
0.1 0.5 GO:0070187 telosome(GO:0070187)
0.0 0.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 5.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 2.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 2.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 2.1 GO:0071837 HMG box domain binding(GO:0071837)
0.2 2.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 2.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 2.0 GO:0005254 chloride channel activity(GO:0005254)
0.2 1.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 1.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 1.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 1.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.2 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 1.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.0 GO:0030507 spectrin binding(GO:0030507)
0.2 0.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.9 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.5 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.7 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 1.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 0.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.5 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport