Motif ID: Hoxd12

Z-value: 0.925


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56969864 5.423 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_+_159737510 5.254 ENSMUST00000111669.3
 Tnr
tenascin R
chr1_-_56969827 4.821 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr13_-_84064772 4.468 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_+_144893127 4.020 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 4.004 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr15_-_8710409 3.442 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_144893077 3.150 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_9403049 2.828 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr16_+_42907563 2.775 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr17_+_3397189 2.670 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chrX_-_143933089 2.426 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_+_81936911 2.393 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr15_-_8710734 2.248 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_19103022 2.138 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr1_-_69108039 2.006 ENSMUST00000121473.1
 Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr10_+_69787431 1.887 ENSMUST00000183240.1
 Ank3
ankyrin 3, epithelial
chr3_-_126998408 1.863 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr9_-_77347816 1.855 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr16_+_11405648 1.850 ENSMUST00000096273.2
 Snx29
sorting nexin 29

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 11.2 GO:0042572 retinol metabolic process(GO:0042572)
0.6 9.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.4 5.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 5.3 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 4.1 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 3.6 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 3.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 3.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 2.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 2.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 2.0 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.2 1.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.8 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.2 1.7 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.3 1.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 1.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 1.5 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.7 GO:0043197 dendritic spine(GO:0043197)
1.8 5.3 GO:0072534 perineuronal net(GO:0072534)
0.0 3.5 GO:0016605 PML body(GO:0016605)
0.0 2.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.4 GO:0030027 lamellipodium(GO:0030027)
0.1 2.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.9 GO:0031430 M band(GO:0031430)
0.0 1.7 GO:0005938 cell cortex(GO:0005938)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.1 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.8 GO:0070820 tertiary granule(GO:0070820)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.5 GO:0042629 mast cell granule(GO:0042629)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.9 5.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 5.3 GO:0046625 sphingolipid binding(GO:0046625)
0.0 5.0 GO:0008017 microtubule binding(GO:0008017)
0.1 4.6 GO:0030507 spectrin binding(GO:0030507)
0.0 4.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.4 3.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 2.0 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 1.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.5 GO:0043422 protein kinase B binding(GO:0043422)
0.1 1.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 1.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 1.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 1.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 1.0 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 5.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.2 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 1.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 2.7 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.0 2.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.0 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 2.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.1 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix