Motif ID: Hoxd12

Z-value: 0.925


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_56969864 5.423 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr1_+_159737510 5.254 ENSMUST00000111669.3
Tnr
tenascin R
chr1_-_56969827 4.821 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr13_-_84064772 4.468 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr4_+_144893127 4.020 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 4.004 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr15_-_8710409 3.442 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_144893077 3.150 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_9403049 2.828 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
C030034L19Rik


RIKEN cDNA C030034L19 gene


chr16_+_42907563 2.775 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr17_+_3397189 2.670 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chrX_-_143933089 2.426 ENSMUST00000087313.3
Dcx
doublecortin
chr15_+_81936911 2.393 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr15_-_8710734 2.248 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_19103022 2.138 ENSMUST00000037294.7
Tfap2d
transcription factor AP-2, delta
chr1_-_69108039 2.006 ENSMUST00000121473.1
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr10_+_69787431 1.887 ENSMUST00000183240.1
Ank3
ankyrin 3, epithelial
chr3_-_126998408 1.863 ENSMUST00000182764.1
ENSMUST00000044443.8
Ank2

ankyrin 2, brain

chr9_-_77347816 1.855 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr16_+_11405648 1.850 ENSMUST00000096273.2
Snx29
sorting nexin 29
chr5_-_62766153 1.809 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_-_35215008 1.749 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr5_+_107497762 1.700 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr15_+_81936753 1.690 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr5_-_73256555 1.657 ENSMUST00000101127.5
ENSMUST00000171179.1
Fryl
Fryl
furry homolog-like (Drosophila)
furry homolog-like (Drosophila)
chr2_+_65930117 1.614 ENSMUST00000176109.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_-_36104060 1.606 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr4_-_88033328 1.597 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr14_-_36919513 1.576 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr14_-_36919314 1.540 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr11_+_29463735 1.531 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr13_-_101692624 1.470 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr1_-_165934900 1.441 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr4_+_136284658 1.402 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr9_-_77347787 1.317 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr4_+_136284708 1.287 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr5_+_107497718 1.270 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr4_+_31964081 1.132 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
Map3k7



mitogen-activated protein kinase kinase kinase 7



chr13_-_97747399 1.108 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_+_81077274 1.099 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr14_+_66868850 1.094 ENSMUST00000100453.1
Gm5464
predicted gene 5464
chr3_+_108591279 1.087 ENSMUST00000051145.8
ENSMUST00000139626.1
Wdr47

WD repeat domain 47

chr4_-_154636831 1.054 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chrX_-_143933204 1.036 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr2_+_73271925 1.035 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr3_+_122419772 1.027 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr2_-_66410064 0.978 ENSMUST00000112366.1
Scn1a
sodium channel, voltage-gated, type I, alpha
chr1_-_152625212 0.958 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr4_-_82505707 0.944 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib

nuclear factor I/B

chr10_+_90071095 0.940 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr3_+_66985680 0.922 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr15_+_25773985 0.835 ENSMUST00000125667.1
Myo10
myosin X
chr12_+_55836365 0.834 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr1_+_81077204 0.825 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr1_-_37496095 0.793 ENSMUST00000148047.1
ENSMUST00000143636.1
Mgat4a

mannoside acetylglucosaminyltransferase 4, isoenzyme A

chr6_+_125215551 0.791 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
Vamp1


vesicle-associated membrane protein 1


chr18_-_37020679 0.775 ENSMUST00000097612.2
Gm10545
predicted gene 10545
chr5_-_74531619 0.701 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr19_+_60755947 0.659 ENSMUST00000088237.4
Nanos1
nanos homolog 1 (Drosophila)
chr5_-_24030649 0.659 ENSMUST00000030849.6
Fam126a
family with sequence similarity 126, member A
chr2_-_180824596 0.626 ENSMUST00000148700.1
Gm14340
predicted gene 14340
chr11_-_109472611 0.599 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr7_-_37772868 0.570 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr11_-_109473220 0.569 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chrX_-_43274786 0.568 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr10_-_30655859 0.560 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr5_+_19907502 0.543 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr4_-_11981265 0.506 ENSMUST00000098260.2
Gm10604
predicted gene 10604
chr19_-_45812291 0.500 ENSMUST00000086993.4
Kcnip2
Kv channel-interacting protein 2
chr5_-_5265224 0.499 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chr9_-_13245741 0.484 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr12_+_33147754 0.476 ENSMUST00000146040.1
ENSMUST00000125192.1
Atxn7l1

ataxin 7-like 1

chr4_+_148000722 0.466 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr1_+_59256906 0.453 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15

cyclin-dependent kinase 15

chr3_+_103575231 0.451 ENSMUST00000121834.1
Syt6
synaptotagmin VI
chr2_+_116900152 0.430 ENSMUST00000126467.1
ENSMUST00000128305.1
ENSMUST00000155323.1
D330050G23Rik


RIKEN cDNA D330050G23 gene


chr2_-_45117349 0.419 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr5_-_62765618 0.416 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_-_35769356 0.410 ENSMUST00000023554.8
Dirc2
disrupted in renal carcinoma 2 (human)
chr9_-_77347889 0.386 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr17_+_31433054 0.372 ENSMUST00000136384.1
Pde9a
phosphodiesterase 9A
chr6_-_119388671 0.363 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chr14_+_32085804 0.357 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1


oxidoreductase NAD-binding domain containing 1


chr2_-_114013619 0.346 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr16_+_65520503 0.342 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1


POU domain, class 1, transcription factor 1


chr13_+_24943144 0.339 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr3_+_66985647 0.338 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr8_-_47352348 0.334 ENSMUST00000110367.2
Stox2
storkhead box 2
chr17_-_91092715 0.331 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr1_+_153874335 0.324 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr4_-_82850721 0.316 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr4_-_82505749 0.284 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib

nuclear factor I/B

chr3_+_66985947 0.259 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr13_+_80883403 0.248 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr3_+_103575275 0.240 ENSMUST00000090697.4
Syt6
synaptotagmin VI
chr18_-_3281712 0.233 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
Crem



cAMP responsive element modulator



chr2_-_140671440 0.214 ENSMUST00000099301.1
Flrt3
fibronectin leucine rich transmembrane protein 3
chr15_+_81744848 0.208 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr11_-_118355496 0.167 ENSMUST00000017610.3
Timp2
tissue inhibitor of metalloproteinase 2
chrX_-_75578188 0.151 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr17_+_73804841 0.130 ENSMUST00000024860.7
Ehd3
EH-domain containing 3
chr17_-_35897073 0.103 ENSMUST00000150056.1
ENSMUST00000156817.1
ENSMUST00000146451.1
ENSMUST00000148482.1
2310061I04Rik



RIKEN cDNA 2310061I04 gene



chr7_+_4922251 0.055 ENSMUST00000047309.5
Nat14
N-acetyltransferase 14
chr16_-_50432340 0.053 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
Bbx




bobby sox homolog (Drosophila)




chr1_-_45503282 0.046 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr10_+_116177351 0.041 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr3_+_8509477 0.036 ENSMUST00000029002.7
Stmn2
stathmin-like 2
chr10_+_119992916 0.036 ENSMUST00000105261.2
Grip1
glutamate receptor interacting protein 1
chr1_-_172027251 0.035 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr3_-_19163011 0.033 ENSMUST00000029125.8
Armc1
armadillo repeat containing 1
chr13_-_99344652 0.023 ENSMUST00000022153.6
Ptcd2
pentatricopeptide repeat domain 2
chr5_+_31054766 0.022 ENSMUST00000013773.5
ENSMUST00000114646.1
Cad

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

chr19_-_43752924 0.015 ENSMUST00000045562.5
Cox15
cytochrome c oxidase assembly protein 15
chr13_-_97747373 0.011 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_63176653 0.006 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 5.3 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.0 11.2 GO:0042572 retinol metabolic process(GO:0042572)
0.6 9.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 2.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.3 1.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 1.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 1.5 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 3.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.7 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 1.1 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.2 1.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.7 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.5 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.9 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.1 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 0.5 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.5 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.3 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.1 0.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.1 0.9 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 1.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 3.6 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 0.2 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.9 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 2.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.7 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 0.6 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.7 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 1.5 GO:0046677 response to antibiotic(GO:0046677)
0.0 4.1 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 3.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:1901387 Golgi to lysosome transport(GO:0090160) positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 1.8 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.0 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 2.0 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 0.8 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0072534 perineuronal net(GO:0072534)
0.2 0.8 GO:0070820 tertiary granule(GO:0070820)
0.1 11.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.9 GO:0031430 M band(GO:0031430)
0.1 2.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.5 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 3.5 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.7 GO:0005938 cell cortex(GO:0005938)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 5.7 GO:0043197 dendritic spine(GO:0043197)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 2.4 GO:0030027 lamellipodium(GO:0030027)
0.0 2.7 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 11.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.9 5.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 2.0 GO:0038132 neuregulin binding(GO:0038132)
0.4 1.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.4 3.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.3 5.3 GO:0046625 sphingolipid binding(GO:0046625)
0.2 1.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 0.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.5 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.4 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 4.6 GO:0030507 spectrin binding(GO:0030507)
0.1 1.5 GO:0043422 protein kinase B binding(GO:0043422)
0.1 1.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 1.0 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 2.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 4.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.8 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 5.0 GO:0008017 microtubule binding(GO:0008017)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.6 GO:0035257 nuclear hormone receptor binding(GO:0035257)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 5.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 5.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.0 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.7 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 1.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 2.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 0.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 2.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix