Motif ID: Hoxd12
Z-value: 0.925
Transcription factors associated with Hoxd12:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxd12 | ENSMUSG00000001823.4 | Hoxd12 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 5.7 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
1.3 | 5.3 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
1.0 | 11.2 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.6 | 9.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
0.4 | 2.0 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
0.3 | 1.6 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.3 | 1.2 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.3 | 1.5 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
0.2 | 3.5 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.2 | 0.7 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
0.2 | 1.1 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
0.2 | 1.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.2 | 1.9 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.2 | 1.7 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.1 | 1.5 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
0.1 | 0.9 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.1 | 1.1 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
0.1 | 0.5 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.1 | 0.5 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
0.1 | 0.3 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
0.1 | 0.3 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) |
0.1 | 0.9 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
0.1 | 1.0 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.1 | 1.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
0.1 | 3.6 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
0.1 | 0.2 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
0.1 | 0.9 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.1 | 0.4 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 2.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.1 | 1.7 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
0.1 | 0.6 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.0 | 0.7 | GO:1900153 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153) |
0.0 | 0.6 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.0 | 0.8 | GO:0035493 | SNARE complex assembly(GO:0035493) |
0.0 | 1.5 | GO:0046677 | response to antibiotic(GO:0046677) |
0.0 | 4.1 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
0.0 | 3.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
0.0 | 1.0 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
0.0 | 0.3 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.0 | 0.4 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
0.0 | 0.2 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
0.0 | 0.7 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
0.0 | 1.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.0 | 0.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.0 | 0.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.0 | 0.1 | GO:1901387 | Golgi to lysosome transport(GO:0090160) positive regulation of voltage-gated calcium channel activity(GO:1901387) |
0.0 | 1.8 | GO:0014065 | phosphatidylinositol 3-kinase signaling(GO:0014065) |
0.0 | 0.0 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.0 | 0.8 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
0.0 | 0.0 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
0.0 | 0.0 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.0 | 2.0 | GO:0043524 | negative regulation of neuron apoptotic process(GO:0043524) |
0.0 | 0.8 | GO:0016575 | histone deacetylation(GO:0016575) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 5.3 | GO:0072534 | perineuronal net(GO:0072534) |
0.2 | 0.8 | GO:0070820 | tertiary granule(GO:0070820) |
0.1 | 11.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.1 | 0.5 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.1 | 0.9 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.1 | 1.9 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.1 | 1.9 | GO:0031430 | M band(GO:0031430) |
0.1 | 2.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.1 | 1.0 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.1 | 1.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.1 | 0.5 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 0.1 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
0.0 | 3.5 | GO:0016605 | PML body(GO:0016605) |
0.0 | 1.6 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 1.7 | GO:0005938 | cell cortex(GO:0005938) |
0.0 | 0.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
0.0 | 5.7 | GO:0043197 | dendritic spine(GO:0043197) |
0.0 | 1.1 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.0 | 1.7 | GO:0005901 | caveola(GO:0005901) |
0.0 | 2.4 | GO:0030027 | lamellipodium(GO:0030027) |
0.0 | 2.7 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 11.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.9 | 5.7 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.4 | 2.0 | GO:0038132 | neuregulin binding(GO:0038132) |
0.4 | 1.5 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
0.4 | 3.6 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
0.3 | 5.3 | GO:0046625 | sphingolipid binding(GO:0046625) |
0.2 | 1.0 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.2 | 0.8 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.1 | 0.5 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
0.1 | 0.5 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.1 | 1.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.1 | 0.4 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
0.1 | 0.3 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.1 | 4.6 | GO:0030507 | spectrin binding(GO:0030507) |
0.1 | 1.5 | GO:0043422 | protein kinase B binding(GO:0043422) |
0.1 | 1.1 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
0.1 | 1.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
0.0 | 1.0 | GO:0031402 | sodium ion binding(GO:0031402) |
0.0 | 0.6 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.0 | 2.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 4.1 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.0 | 0.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.3 | GO:0004630 | phospholipase D activity(GO:0004630) |
0.0 | 0.5 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.0 | 1.2 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
0.0 | 1.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 2.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 1.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
0.0 | 0.4 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
0.0 | 0.8 | GO:0004407 | histone deacetylase activity(GO:0004407) |
0.0 | 5.0 | GO:0008017 | microtubule binding(GO:0008017) |
0.0 | 0.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 0.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 1.3 | GO:0033613 | activating transcription factor binding(GO:0033613) |
0.0 | 0.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.0 | 0.2 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
0.0 | 0.3 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.6 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 10.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.1 | 2.0 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.1 | 3.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.1 | 1.1 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.1 | 1.5 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.1 | 1.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.1 | 2.2 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 1.7 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 1.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 2.7 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
0.0 | 5.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.0 | 0.3 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.1 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
0.1 | 1.5 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.1 | 5.7 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.1 | 2.0 | REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
0.1 | 0.8 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
0.1 | 2.7 | REACTOME_RNA_POL_III_TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |
0.1 | 1.9 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 0.8 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.0 | 2.7 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.0 | 2.8 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
0.0 | 0.3 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
0.0 | 0.5 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
0.0 | 2.0 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.0 | 0.5 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
0.0 | 0.4 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 0.3 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
0.0 | 0.2 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |