Motif ID: Gata4

Z-value: 0.636


Transcription factors associated with Gata4:

Gene SymbolEntrez IDGene Name
Gata4 ENSMUSG00000021944.9 Gata4



Activity profile for motif Gata4.

activity profile for motif Gata4


Sorted Z-values histogram for motif Gata4

Sorted Z-values for motif Gata4



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata4

PNG image of the network

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Top targets:


Showing 1 to 20 of 125 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_103510874 2.168 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr5_-_73191848 1.846 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr10_-_62342674 1.510 ENSMUST00000143179.1
ENSMUST00000130422.1
 Hk1

hexokinase 1

chr1_-_56969827 1.371 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr2_-_59948155 1.303 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr16_-_34263179 1.299 ENSMUST00000114949.1
ENSMUST00000114954.1
 Kalrn

kalirin, RhoGEF kinase

chr2_+_4559742 1.279 ENSMUST00000176828.1
 Frmd4a
FERM domain containing 4A
chr1_-_56969864 1.258 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_+_180851131 1.238 ENSMUST00000038091.6
 Sde2
SDE2 telomere maintenance homolog (S. pombe)
chr16_-_34262830 1.228 ENSMUST00000114947.1
 Kalrn
kalirin, RhoGEF kinase
chr10_-_83648631 1.129 ENSMUST00000146876.2
ENSMUST00000176294.1
 Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr4_-_82705735 1.058 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr16_+_45093611 1.036 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr5_+_64812336 0.967 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr9_+_66350465 0.938 ENSMUST00000042824.6
 Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr11_+_3330781 0.929 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr10_+_84576626 0.914 ENSMUST00000020223.7
 Tcp11l2
t-complex 11 (mouse) like 2
chr8_+_45628176 0.906 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr2_+_65845833 0.850 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_-_7081207 0.837 ENSMUST00000114923.2
ENSMUST00000182706.1
 Celf2

CUGBP, Elav-like family member 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.3 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.2 2.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 2.2 GO:0035640 exploration behavior(GO:0035640)
0.1 2.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 1.8 GO:0090527 actin filament reorganization(GO:0090527)
0.2 1.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 1.5 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 1.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.4 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 1.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 1.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 1.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.9 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.9 GO:0001541 ovarian follicle development(GO:0001541)
0.2 0.8 GO:0090472 dibasic protein processing(GO:0090472)
0.1 0.8 GO:0035878 nail development(GO:0035878)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 GO:0014069 postsynaptic density(GO:0014069)
0.0 2.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.5 GO:0097228 sperm principal piece(GO:0097228)
0.4 1.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.8 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 0.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.8 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.6 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.5 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0097427 microtubule bundle(GO:0097427)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 1.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.3 1.5 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.4 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 1.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 1.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.0 GO:0001968 fibronectin binding(GO:0001968)
0.2 0.9 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 0.8 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.7 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.7 GO:0045499 chemorepellent activity(GO:0045499)
0.2 0.6 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.5 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 2.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.9 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 0.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.5 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.2 1.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.1 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 0.8 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.7 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.7 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.6 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis