Motif ID: Mzf1

Z-value: 0.594


Transcription factors associated with Mzf1:

Gene SymbolEntrez IDGene Name
Mzf1 ENSMUSG00000030380.10 Mzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mzf1mm10_v2_chr7_-_13054665_130547640.494.0e-02Click!


Activity profile for motif Mzf1.

activity profile for motif Mzf1


Sorted Z-values histogram for motif Mzf1

Sorted Z-values for motif Mzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 1.854 ENSMUST00000165033.1
 Egr1
early growth response 1
chr19_-_5796924 1.381 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr11_+_79339792 1.076 ENSMUST00000108251.2
ENSMUST00000071325.2
 Nf1

neurofibromatosis 1

chr14_-_30353468 1.008 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr7_+_49246812 0.978 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr10_-_127620960 0.973 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr1_-_56971762 0.959 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr9_-_98033181 0.888 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr10_-_127620922 0.882 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr10_+_13966268 0.866 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chrX_-_143933089 0.835 ENSMUST00000087313.3
 Dcx
doublecortin
chr10_+_89873497 0.818 ENSMUST00000183156.1
ENSMUST00000182936.1
ENSMUST00000099368.4
 Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr12_+_105336922 0.814 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr16_+_44173271 0.793 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr4_+_104367549 0.793 ENSMUST00000106830.2
 Dab1
disabled 1
chr2_-_39190687 0.781 ENSMUST00000142872.1
ENSMUST00000038874.5
 Scai

suppressor of cancer cell invasion

chr16_+_41532999 0.778 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr11_+_105589970 0.740 ENSMUST00000168598.1
ENSMUST00000100330.3
 Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr19_+_44931119 0.739 ENSMUST00000096053.3
 Fam178a
family with sequence similarity 178, member A
chr9_-_44881274 0.733 ENSMUST00000002095.3
ENSMUST00000114689.1
ENSMUST00000128768.1
 Kmt2a


lysine (K)-specific methyltransferase 2A



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 245 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.6 1.9 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.5 1.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.3 1.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 1.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 1.4 GO:0035063 nuclear speck organization(GO:0035063)
0.2 1.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 1.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 1.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.3 1.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 1.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.1 GO:1903859 regulation of dendrite extension(GO:1903859)
0.2 1.0 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.1 1.0 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 1.0 GO:0002076 osteoblast development(GO:0002076)
0.0 1.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 0.9 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 0.9 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.1 0.9 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 0.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.0 GO:0055037 recycling endosome(GO:0055037)
0.0 2.0 GO:0099572 postsynaptic specialization(GO:0099572)
0.0 1.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 1.7 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 1.6 GO:0033268 node of Ranvier(GO:0033268)
0.1 1.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.3 1.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.0 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.9 GO:1990909 Wnt signalosome(GO:1990909)
0.1 0.9 GO:1902710 GABA receptor complex(GO:1902710)
0.1 0.9 GO:0031143 pseudopodium(GO:0031143)
0.1 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.9 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.6 1.9 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.5 1.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 1.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 1.8 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 1.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.7 GO:0030507 spectrin binding(GO:0030507)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.2 1.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 1.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 1.1 GO:0045545 syndecan binding(GO:0045545)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.1 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 1.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.9 GO:0034061 DNA polymerase activity(GO:0034061)
0.2 0.8 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 1.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.6 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.2 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 1.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.6 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.4 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.3 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.8 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.0 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 0.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 0.5 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 0.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport