Motif ID: Sox18_Sox12

Z-value: 0.654

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox12mm10_v2_chr2_-_152398046_1523980760.484.6e-02Click!
Sox18mm10_v2_chr2_-_181671622_181671645-0.107.0e-01Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_11970540 1.623 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr6_-_113934679 1.386 ENSMUST00000101044.2
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr9_-_60511003 1.367 ENSMUST00000098660.3
 Thsd4
thrombospondin, type I, domain containing 4
chr18_-_74961252 1.293 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr18_-_88927447 1.262 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr14_+_62837679 1.176 ENSMUST00000014691.8
 Wdfy2
WD repeat and FYVE domain containing 2
chr16_-_23520579 1.130 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr7_+_24271568 0.995 ENSMUST00000032696.6
 Zfp93
zinc finger protein 93
chr2_+_25180737 0.947 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chrX_+_56779699 0.945 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
 Fhl1


four and a half LIM domains 1


chr19_-_34527396 0.937 ENSMUST00000049572.8
ENSMUST00000178114.1
 Lipa

lysosomal acid lipase A

chr14_+_116925379 0.895 ENSMUST00000088483.3
 Gpc6
glypican 6
chr4_-_58499398 0.891 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr16_-_91618986 0.871 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr7_+_75643223 0.837 ENSMUST00000137959.1
 Akap13
A kinase (PRKA) anchor protein 13
chr11_-_62392605 0.835 ENSMUST00000151498.2
ENSMUST00000159069.1
 Ncor1

nuclear receptor co-repressor 1

chr5_+_92809372 0.784 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr2_+_119034783 0.611 ENSMUST00000028796.1
 Rpusd2
RNA pseudouridylate synthase domain containing 2
chr14_-_100149764 0.584 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr1_-_133921393 0.583 ENSMUST00000048432.5
 Prelp
proline arginine-rich end leucine-rich repeat

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 1.4 GO:0048840 otolith development(GO:0048840)
0.2 1.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 1.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.3 1.3 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 1.2 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.2 1.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 1.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.2 0.9 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.9 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 0.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.9 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.2 0.8 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.1 0.8 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.6 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.2 0.5 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.5 GO:0033326 cerebrospinal fluid secretion(GO:0033326)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0005769 early endosome(GO:0005769)
0.1 1.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.4 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.3 GO:0001772 immunological synapse(GO:0001772)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.1 0.9 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.8 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.2 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 1.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 1.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.1 GO:0016298 lipase activity(GO:0016298)
0.1 1.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.0 GO:0030507 spectrin binding(GO:0030507)
0.2 0.8 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 0.8 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.5 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.1 0.5 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.4 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.2 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.2 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 1.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.7 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 0.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.1 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.0 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway