Motif ID: Nkx3-1

Z-value: 0.603


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_78191966 1.662 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr4_-_132757162 1.485 ENSMUST00000030709.8
 Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr4_-_140774196 1.443 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV
chr1_-_133907053 1.322 ENSMUST00000149380.1
ENSMUST00000124051.2
 Optc

opticin

chr1_-_163289214 1.196 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr1_-_133906973 1.033 ENSMUST00000126123.1
 Optc
opticin
chrX_+_100625737 0.955 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr10_-_13324160 0.877 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr3_-_104818539 0.862 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
 Mov10



Moloney leukemia virus 10



chr5_-_149051300 0.801 ENSMUST00000110505.1
 Hmgb1
high mobility group box 1
chr9_-_124493793 0.783 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chrX_+_164269371 0.777 ENSMUST00000145412.1
ENSMUST00000033749.7
 Pir

pirin

chr3_-_57575760 0.733 ENSMUST00000029380.7
 Wwtr1
WW domain containing transcription regulator 1
chr13_-_99900645 0.719 ENSMUST00000022150.6
 Cartpt
CART prepropeptide
chr3_-_57575907 0.705 ENSMUST00000120977.1
 Wwtr1
WW domain containing transcription regulator 1
chr4_+_3940747 0.695 ENSMUST00000119403.1
 Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr2_-_84775420 0.693 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr5_-_8422582 0.691 ENSMUST00000168500.1
ENSMUST00000002368.9
 Dbf4

DBF4 homolog (S. cerevisiae)

chr6_+_128362919 0.684 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr8_+_114133635 0.652 ENSMUST00000147605.1
ENSMUST00000134593.1
 Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.2 1.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 1.4 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.2 1.4 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.4 1.3 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.4 1.3 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.1 1.2 GO:0048664 neuron fate determination(GO:0048664)
0.1 1.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.9 GO:0006379 mRNA cleavage(GO:0006379)
0.3 0.8 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.8 GO:0070986 left/right axis specification(GO:0070986)
0.2 0.7 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.1 0.7 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.7 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.1 0.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.6 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.6 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.6 GO:0030224 monocyte differentiation(GO:0030224)
0.1 0.5 GO:2000407 regulation of T cell extravasation(GO:2000407)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.8 GO:0005882 intermediate filament(GO:0005882)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.1 0.5 GO:0097342 ripoptosome(GO:0097342)
0.1 0.4 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0070938 contractile ring(GO:0070938)
0.0 0.4 GO:0042611 MHC protein complex(GO:0042611)
0.1 0.3 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.0 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 1.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.4 1.4 GO:0034618 arginine binding(GO:0034618)
0.4 1.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 1.3 GO:0001848 complement binding(GO:0001848)
0.0 1.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.3 0.8 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.8 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 0.5 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.5 GO:0042731 PH domain binding(GO:0042731)
0.1 0.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.4 GO:0070569 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.0 0.4 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.4 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.3 GO:0070330 aromatase activity(GO:0070330)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.3 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.7 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 0.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation