Motif ID: Emx1_Emx2
Z-value: 0.726
Transcription factors associated with Emx1_Emx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Emx1 | ENSMUSG00000033726.8 | Emx1 |
Emx2 | ENSMUSG00000043969.4 | Emx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Emx2 | mm10_v2_chr19_+_59458372_59458450 | -0.38 | 1.2e-01 | Click! |
Emx1 | mm10_v2_chr6_+_85187438_85187510 | -0.04 | 8.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.8 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
0.2 | 0.7 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 0.4 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
0.1 | 1.0 | GO:0014043 | negative regulation of neuron maturation(GO:0014043) |
0.1 | 0.3 | GO:0050787 | glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) |
0.1 | 0.5 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
0.1 | 0.4 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.1 | 0.8 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.1 | 1.1 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.1 | 0.3 | GO:0060060 | post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
0.1 | 0.3 | GO:0097360 | chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382) |
0.1 | 0.2 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.1 | 0.2 | GO:2000016 | negative regulation of determination of dorsal identity(GO:2000016) |
0.1 | 0.1 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) |
0.0 | 0.2 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
0.0 | 0.1 | GO:0019343 | cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) |
0.0 | 0.4 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
0.0 | 0.4 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
0.0 | 0.1 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
0.0 | 0.1 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
0.0 | 0.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.0 | 0.2 | GO:0035617 | stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150) |
0.0 | 0.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.0 | 0.2 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
0.0 | 0.2 | GO:0070295 | renal water absorption(GO:0070295) |
0.0 | 0.1 | GO:0072014 | proximal tubule development(GO:0072014) |
0.0 | 0.2 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
0.0 | 0.4 | GO:0015816 | glycine transport(GO:0015816) |
0.0 | 0.3 | GO:0036159 | outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159) |
0.0 | 0.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
0.0 | 0.2 | GO:0032264 | IMP salvage(GO:0032264) |
0.0 | 0.1 | GO:1902995 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427) |
0.0 | 0.1 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.0 | 0.2 | GO:0008356 | asymmetric cell division(GO:0008356) asymmetric neuroblast division(GO:0055059) asymmetric stem cell division(GO:0098722) |
0.0 | 0.1 | GO:0051189 | molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189) |
0.0 | 0.1 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
0.0 | 0.1 | GO:1902512 | positive regulation of apoptotic DNA fragmentation(GO:1902512) |
0.0 | 0.1 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
0.0 | 0.2 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.0 | 0.0 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
0.0 | 1.0 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
0.0 | 0.2 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
0.0 | 0.3 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.0 | 0.0 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
0.0 | 0.1 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
0.0 | 0.1 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.8 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
0.1 | 0.4 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
0.1 | 0.5 | GO:0005859 | muscle myosin complex(GO:0005859) |
0.1 | 0.2 | GO:0043512 | inhibin A complex(GO:0043512) |
0.1 | 0.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.1 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
0.0 | 0.2 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
0.0 | 0.1 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.0 | 0.1 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
0.0 | 0.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.0 | 0.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
0.0 | 0.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.1 | GO:0061617 | MICOS complex(GO:0061617) |
0.0 | 0.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 0.0 | GO:1990075 | kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075) |
0.0 | 0.3 | GO:0005685 | U1 snRNP(GO:0005685) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.4 | GO:0031721 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
0.1 | 0.3 | GO:0036470 | tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) |
0.1 | 0.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
0.1 | 0.7 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.1 | 2.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.1 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
0.1 | 0.2 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
0.1 | 0.2 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.0 | 0.3 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.0 | 0.1 | GO:0098809 | nitrite reductase activity(GO:0098809) |
0.0 | 0.4 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
0.0 | 0.1 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
0.0 | 0.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
0.0 | 0.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.0 | 0.1 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
0.0 | 0.4 | GO:0001618 | virus receptor activity(GO:0001618) |
0.0 | 0.2 | GO:0098821 | BMP receptor activity(GO:0098821) |
0.0 | 0.4 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.0 | 0.3 | GO:0015250 | water channel activity(GO:0015250) |
0.0 | 0.1 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
0.0 | 0.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
0.0 | 0.8 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.0 | 0.2 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
0.0 | 0.2 | GO:0099609 | microtubule lateral binding(GO:0099609) |
0.0 | 1.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.0 | 1.1 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.4 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.0 | 0.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
0.0 | 0.3 | GO:0051400 | BH domain binding(GO:0051400) |
0.0 | 1.0 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.0 | 0.1 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
0.0 | 0.0 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
0.0 | 0.2 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.0 | 0.6 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 0.0 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.0 | 0.1 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
0.0 | 0.1 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.0 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 0.4 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 0.3 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.0 | 1.4 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.0 | 0.8 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.0 | 0.1 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.8 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
0.1 | 0.2 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.0 | 0.4 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.0 | 0.8 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 0.5 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 0.3 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 0.2 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.0 | 0.4 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
0.0 | 0.5 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 0.3 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
0.0 | 0.2 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.0 | 0.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.0 | 0.3 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 0.4 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
0.0 | 0.2 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.0 | 0.2 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |