Motif ID: Hoxa11_Hoxc12

Z-value: 1.357

Transcription factors associated with Hoxa11_Hoxc12:

Gene SymbolEntrez IDGene Name
Hoxa11 ENSMUSG00000038210.9 Hoxa11
Hoxc12 ENSMUSG00000050328.2 Hoxc12



Activity profile for motif Hoxa11_Hoxc12.

activity profile for motif Hoxa11_Hoxc12


Sorted Z-values histogram for motif Hoxa11_Hoxc12

Sorted Z-values for motif Hoxa11_Hoxc12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa11_Hoxc12

PNG image of the network

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Top targets:


Showing 1 to 20 of 124 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_43730593 7.564 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr17_+_35076902 7.396 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr1_-_56978534 6.102 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr17_+_6270475 4.792 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr14_+_80000292 4.636 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_+_108213086 4.437 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr13_+_16014457 4.103 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr16_-_57231434 3.902 ENSMUST00000023431.6
 Tbc1d23
TBC1 domain family, member 23
chr17_-_6477102 3.735 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr15_-_43869993 2.943 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr11_-_62457772 2.589 ENSMUST00000127471.2
 Ncor1
nuclear receptor co-repressor 1
chr17_+_22361453 2.501 ENSMUST00000149699.1
ENSMUST00000088765.2
ENSMUST00000072477.4
ENSMUST00000121315.1
 Zfp758



zinc finger protein 758



chr14_+_27622433 2.449 ENSMUST00000090302.5
 Erc2
ELKS/RAB6-interacting/CAST family member 2
chr18_+_69346143 2.375 ENSMUST00000114980.1
 Tcf4
transcription factor 4
chr9_-_55919605 2.245 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr3_-_117360876 2.193 ENSMUST00000061071.8
 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr5_+_66968961 2.072 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr16_-_45408955 2.043 ENSMUST00000163230.1
 Cd200
CD200 antigen
chrX_+_73064787 2.018 ENSMUST00000060418.6
 Pnma3
paraneoplastic antigen MA3
chr2_-_180824596 1.989 ENSMUST00000148700.1
 Gm14340
predicted gene 14340

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.6 GO:0070314 G1 to G0 transition(GO:0070314)
0.3 7.4 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.4 6.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 4.8 GO:0009405 pathogenesis(GO:0009405)
0.1 4.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.7 4.4 GO:0042045 epithelial fluid transport(GO:0042045)
1.4 4.2 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.8 4.1 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 4.1 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.1 3.2 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 2.9 GO:0016236 macroautophagy(GO:0016236)
0.6 2.6 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.2 2.4 GO:0042118 endothelial cell activation(GO:0042118)
0.0 2.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.7 2.0 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.1 1.7 GO:0051764 actin crosslink formation(GO:0051764)
0.5 1.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.5 GO:0030242 pexophagy(GO:0030242)
0.2 1.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 1.4 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0031045 dense core granule(GO:0031045)
0.1 6.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 5.2 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.4 4.6 GO:0042581 specific granule(GO:0042581)
1.5 4.4 GO:0031088 platelet dense granule membrane(GO:0031088)
1.4 4.1 GO:0043512 inhibin A complex(GO:0043512)
0.2 3.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.4 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.9 GO:0034704 calcium channel complex(GO:0034704)
0.3 1.7 GO:1990393 3M complex(GO:1990393)
0.0 1.7 GO:0031941 filamentous actin(GO:0031941)
0.0 1.6 GO:0030673 axolemma(GO:0030673)
0.1 1.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 1.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 1.0 GO:0000502 proteasome complex(GO:0000502)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.3 0.8 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.7 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 7.4 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 6.6 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 4.8 GO:0015643 toxic substance binding(GO:0015643)
1.5 4.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.7 4.2 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.7 4.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.5 3.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 2.8 GO:0008017 microtubule binding(GO:0008017)
0.3 2.6 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 2.5 GO:0030165 PDZ domain binding(GO:0030165)
0.6 2.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.2 1.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.3 1.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 1.0 GO:0070728 leucine binding(GO:0070728)
0.2 0.8 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 0.8 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 4.1 PID_ALK1_PATHWAY ALK1 signaling events
0.1 3.4 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 2.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 4.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 3.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.0 1.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.2 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.1 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters