Motif ID: Nfatc4

Z-value: 0.828


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.798.4e-05Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Showing 1 to 20 of 63 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 4.027 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr4_+_48049080 3.891 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_-_56978534 3.818 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 2.911 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_+_26623419 2.706 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_+_92051153 2.488 ENSMUST00000169825.1
 Cntn1
contactin 1
chr19_-_4943049 1.970 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr11_+_97415527 1.841 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr2_-_66410064 1.644 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr6_-_59024470 1.574 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr1_-_170110491 1.573 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr16_+_43364145 1.493 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr6_-_59024340 1.480 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr1_+_34005872 1.120 ENSMUST00000182296.1
 Dst
dystonin
chr9_+_113812547 1.067 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr14_+_70555900 1.050 ENSMUST00000163060.1
 Hr
hairless
chr2_+_55435918 1.022 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr15_-_79932516 0.919 ENSMUST00000177044.1
ENSMUST00000109615.1
ENSMUST00000089293.4
ENSMUST00000109616.2
 Cbx7



chromobox 7



chr12_-_84450944 0.863 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr13_-_52981027 0.846 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.3 4.0 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.3 3.9 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 2.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 2.6 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 2.5 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.7 2.0 GO:0070428 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.2 1.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 1.0 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 1.0 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.3 0.9 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.9 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.8 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.8 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.3 0.6 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.4 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 4.0 GO:0030017 sarcomere(GO:0030017)
0.1 2.7 GO:0071564 npBAF complex(GO:0071564)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 1.1 GO:0031673 H zone(GO:0031673)
0.3 1.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.9 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.8 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.0 GO:0003680 AT DNA binding(GO:0003680)
0.1 3.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 2.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 1.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.1 GO:0002162 dystroglycan binding(GO:0002162)
0.2 1.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.9 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.4 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0017075 syntaxin-1 binding(GO:0017075)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 3.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 2.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 3.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 2.0 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling