Motif ID: Bcl6

Z-value: 1.082


Transcription factors associated with Bcl6:

Gene SymbolEntrez IDGene Name
Bcl6 ENSMUSG00000022508.5 Bcl6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl6mm10_v2_chr16_-_23988852_239888520.814.4e-05Click!


Activity profile for motif Bcl6.

activity profile for motif Bcl6


Sorted Z-values histogram for motif Bcl6

Sorted Z-values for motif Bcl6



Network of associatons between targets according to the STRING database.



First level regulatory network of Bcl6

PNG image of the network

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Top targets:


Showing 1 to 20 of 188 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169747634 6.673 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chrX_-_61185558 4.318 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr4_-_64046925 4.077 ENSMUST00000107377.3
 Tnc
tenascin C
chr3_-_152982240 2.880 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_-_80802789 2.619 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr10_+_100015817 2.512 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr4_+_144892813 2.165 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr9_+_107296843 2.115 ENSMUST00000167072.1
 Cish
cytokine inducible SH2-containing protein
chr12_+_88953399 2.081 ENSMUST00000057634.7
 Nrxn3
neurexin III
chr9_+_50752758 1.945 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr7_+_66839726 1.915 ENSMUST00000098382.3
 Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr2_+_70563435 1.905 ENSMUST00000123330.1
 Gad1
glutamate decarboxylase 1
chr2_-_7081207 1.848 ENSMUST00000114923.2
ENSMUST00000182706.1
 Celf2

CUGBP, Elav-like family member 2

chr2_+_70562854 1.837 ENSMUST00000130998.1
 Gad1
glutamate decarboxylase 1
chr10_+_58813359 1.810 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr3_-_120886691 1.771 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr3_+_38886940 1.762 ENSMUST00000061260.7
 Fat4
FAT tumor suppressor homolog 4 (Drosophila)
chr6_-_13838432 1.705 ENSMUST00000115492.1
 Gpr85
G protein-coupled receptor 85
chr11_+_101245996 1.675 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr18_+_37484955 1.653 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.8 5.5 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.5 5.0 GO:0042572 retinol metabolic process(GO:0042572)
1.0 4.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.4 4.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 3.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 2.9 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 2.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.6 2.5 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 2.1 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 2.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.3 1.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.9 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.4 1.8 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 1.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 1.7 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 1.7 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 1.7 GO:0007416 synapse assembly(GO:0007416)
0.2 1.6 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.0 1.6 GO:0007520 myoblast fusion(GO:0007520)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 4.4 GO:0060077 inhibitory synapse(GO:0060077)
0.3 4.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.7 GO:0031672 A band(GO:0031672)
0.1 2.6 GO:0032279 asymmetric synapse(GO:0032279)
0.0 2.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.0 GO:0005903 brush border(GO:0005903)
0.3 1.9 GO:0097512 cardiac myofibril(GO:0097512)
0.3 1.7 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 1.5 GO:0097228 sperm principal piece(GO:0097228)
0.1 1.0 GO:0044292 dendrite terminus(GO:0044292)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.3 0.8 GO:0005940 septin ring(GO:0005940)
0.1 0.8 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.7 GO:0031201 SNARE complex(GO:0031201)
0.1 0.6 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.4 GO:0097447 dendritic tree(GO:0097447)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.7 5.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 5.0 GO:0030507 spectrin binding(GO:0030507)
0.7 4.1 GO:0045545 syndecan binding(GO:0045545)
0.5 3.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 3.1 GO:0008237 metallopeptidase activity(GO:0008237)
0.4 2.9 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.4 2.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 2.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 2.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 2.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.4 1.9 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 1.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.3 1.7 GO:0097643 amylin receptor activity(GO:0097643)
0.3 1.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.5 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 1.5 GO:0043014 alpha-tubulin binding(GO:0043014)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.3 3.7 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 2.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.6 PID_IL2_1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 4.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.3 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.2 3.7 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 2.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 2.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.1 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.0 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.9 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 0.7 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex