Motif ID: Nfil3_Tef
Z-value: 2.305
Transcription factors associated with Nfil3_Tef:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfil3 | ENSMUSG00000056749.7 | Nfil3 |
| Tef | ENSMUSG00000022389.8 | Tef |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tef | mm10_v2_chr15_+_81811414_81811491 | 0.90 | 3.0e-07 | Click! |
| Nfil3 | mm10_v2_chr13_-_52981027_52981083 | 0.85 | 7.0e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 24.4 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 4.0 | 12.0 | GO:0031554 | regulation of DNA-templated transcription, termination(GO:0031554) |
| 3.1 | 9.2 | GO:0099548 | drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548) |
| 2.7 | 16.2 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 2.3 | 15.9 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 1.4 | 5.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 1.4 | 4.1 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) |
| 1.3 | 6.3 | GO:0051012 | microtubule sliding(GO:0051012) |
| 1.2 | 6.2 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 1.1 | 4.4 | GO:0032289 | central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912) |
| 1.1 | 7.7 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 1.1 | 6.4 | GO:0048840 | otolith development(GO:0048840) |
| 1.0 | 10.2 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 1.0 | 2.9 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
| 0.9 | 4.4 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 0.8 | 4.8 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 0.8 | 3.9 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.7 | 2.1 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.7 | 2.1 | GO:1901894 | regulation of calcium-transporting ATPase activity(GO:1901894) |
| 0.7 | 2.7 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.7 | 1.4 | GO:0002034 | angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) |
| 0.6 | 3.2 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.6 | 4.9 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.6 | 1.8 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.6 | 1.7 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.5 | 3.6 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.5 | 3.9 | GO:0060371 | regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) |
| 0.5 | 1.4 | GO:0061744 | motor behavior(GO:0061744) |
| 0.5 | 4.2 | GO:0019896 | axonal transport of mitochondrion(GO:0019896) |
| 0.4 | 3.0 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.4 | 1.2 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.4 | 1.2 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.4 | 2.8 | GO:0002674 | negative regulation of acute inflammatory response(GO:0002674) |
| 0.4 | 2.0 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.4 | 5.1 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
| 0.4 | 1.9 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.4 | 0.7 | GO:0071677 | positive regulation of mononuclear cell migration(GO:0071677) |
| 0.4 | 1.1 | GO:0034035 | sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.3 | 3.5 | GO:0045187 | regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.3 | 3.2 | GO:0006983 | ER overload response(GO:0006983) |
| 0.3 | 2.2 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.3 | 2.1 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.3 | 3.3 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.3 | 0.8 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.3 | 1.6 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.2 | 1.2 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.2 | 1.0 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
| 0.2 | 0.7 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.2 | 1.2 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.2 | 1.6 | GO:0014043 | negative regulation of neuron maturation(GO:0014043) |
| 0.2 | 4.5 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.2 | 1.7 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.2 | 0.6 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.2 | 0.6 | GO:0009446 | putrescine biosynthetic process(GO:0009446) |
| 0.2 | 1.3 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
| 0.2 | 0.6 | GO:1990927 | negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.2 | 0.4 | GO:0010040 | response to iron(II) ion(GO:0010040) |
| 0.2 | 5.3 | GO:0071625 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) vocalization behavior(GO:0071625) |
| 0.2 | 1.4 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.2 | 1.4 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.2 | 1.2 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.2 | 0.8 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.2 | 1.1 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 0.2 | 0.5 | GO:1900149 | positive regulation of Schwann cell migration(GO:1900149) |
| 0.2 | 0.2 | GO:1902856 | negative regulation of nonmotile primary cilium assembly(GO:1902856) |
| 0.1 | 0.4 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.1 | 0.4 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
| 0.1 | 0.7 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.1 | 0.3 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.1 | 1.3 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.1 | 1.6 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
| 0.1 | 1.4 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 0.4 | GO:0070859 | positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253) |
| 0.1 | 1.5 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.1 | 0.9 | GO:0015919 | peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046) |
| 0.1 | 1.3 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.1 | 1.3 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 2.9 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.1 | 0.2 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.1 | 0.4 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 0.3 | GO:1902047 | polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 0.9 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.1 | 0.5 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.1 | 0.5 | GO:1902004 | positive regulation of beta-amyloid formation(GO:1902004) |
| 0.1 | 1.3 | GO:0021542 | dentate gyrus development(GO:0021542) |
| 0.1 | 1.8 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.1 | 0.3 | GO:0001575 | globoside metabolic process(GO:0001575) |
| 0.1 | 0.8 | GO:0006098 | pentose-phosphate shunt(GO:0006098) |
| 0.1 | 7.4 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.1 | 2.3 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.0 | 0.4 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.0 | 2.5 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.0 | 3.4 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.0 | 2.6 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.0 | 0.4 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
| 0.0 | 0.6 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.0 | 4.1 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 1.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.7 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.4 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.0 | 0.9 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.0 | 0.8 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.0 | 0.1 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962) purinergic nucleotide receptor signaling pathway(GO:0035590) positive regulation of penile erection(GO:0060406) |
| 0.0 | 1.1 | GO:0007616 | long-term memory(GO:0007616) |
| 0.0 | 0.3 | GO:0097369 | sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.1 | GO:0086023 | adrenergic receptor signaling pathway involved in heart process(GO:0086023) |
| 0.0 | 1.1 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
| 0.0 | 0.3 | GO:0032402 | establishment of melanosome localization(GO:0032401) melanosome transport(GO:0032402) |
| 0.0 | 0.5 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.2 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.0 | 3.2 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 0.7 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 0.4 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 0.2 | GO:0032717 | negative regulation of interleukin-8 production(GO:0032717) |
| 0.0 | 0.9 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 2.4 | GO:0016052 | carbohydrate catabolic process(GO:0016052) |
| 0.0 | 1.8 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 0.5 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
| 0.0 | 0.5 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 3.7 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.0 | 0.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.7 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.2 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.0 | 0.3 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 2.0 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.1 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 24.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 1.3 | 3.9 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.8 | 12.7 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.8 | 9.2 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.8 | 3.2 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.6 | 2.5 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.6 | 5.3 | GO:0005883 | neurofilament(GO:0005883) |
| 0.5 | 7.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.3 | 6.4 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.3 | 2.3 | GO:0070695 | FHF complex(GO:0070695) |
| 0.3 | 2.9 | GO:0042581 | specific granule(GO:0042581) |
| 0.3 | 4.6 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.3 | 5.1 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.3 | 3.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 0.7 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 1.7 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.1 | 4.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 1.3 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 2.2 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 4.7 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 0.8 | GO:0000805 | X chromosome(GO:0000805) |
| 0.1 | 0.5 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 1.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.8 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.1 | 2.1 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 0.2 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.1 | 1.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 3.1 | GO:0031672 | A band(GO:0031672) |
| 0.1 | 6.4 | GO:0005930 | axoneme(GO:0005930) |
| 0.1 | 0.7 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 1.6 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 0.3 | GO:0030286 | dynein complex(GO:0030286) |
| 0.1 | 0.6 | GO:0032009 | early phagosome(GO:0032009) |
| 0.1 | 1.2 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 0.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 3.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 4.1 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 1.1 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.4 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.9 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 1.2 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.9 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 4.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 1.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.2 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 1.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.4 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 1.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.6 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.9 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 7.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 2.9 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.4 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 8.9 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 6.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 16.2 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 3.2 | 9.5 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 1.5 | 6.2 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 1.3 | 7.5 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.1 | 3.4 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 1.1 | 3.2 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 1.0 | 4.1 | GO:1903135 | cupric ion binding(GO:1903135) |
| 1.0 | 24.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.8 | 2.4 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
| 0.8 | 4.9 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.8 | 12.0 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.8 | 4.5 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.7 | 2.9 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.7 | 2.1 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.7 | 2.7 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.7 | 3.9 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.6 | 2.5 | GO:0031721 | haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721) |
| 0.6 | 3.9 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.5 | 2.2 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 0.5 | 2.8 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.5 | 8.7 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.4 | 6.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.4 | 1.1 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.4 | 1.4 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.3 | 1.0 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.3 | 3.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.3 | 1.3 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.3 | 2.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.3 | 1.2 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.3 | 4.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.2 | 3.6 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.2 | 1.4 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.2 | 6.1 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 5.1 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.2 | 0.6 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924) |
| 0.2 | 1.2 | GO:0009374 | biotin binding(GO:0009374) |
| 0.2 | 1.7 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.2 | 0.9 | GO:0042979 | ornithine decarboxylase regulator activity(GO:0042979) |
| 0.2 | 1.2 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.2 | 0.8 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.2 | 3.0 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 5.3 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 0.4 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.1 | 4.1 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.4 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.1 | 0.4 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.1 | 1.7 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 1.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.7 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.1 | 1.1 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.1 | 0.7 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.1 | 0.4 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.1 | 1.8 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.1 | 0.9 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.1 | 4.1 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 0.5 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.1 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
| 0.0 | 1.1 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 0.4 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.0 | 0.3 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 1.0 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.9 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 4.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 3.5 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 0.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 1.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 1.8 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 1.2 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.0 | 0.2 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.0 | 1.1 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 0.4 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 0.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 0.5 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.1 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.0 | 1.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 8.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 2.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 4.5 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 3.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.6 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 1.0 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 5.2 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.0 | 1.1 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.6 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 4.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 2.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.0 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.3 | 24.4 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 7.6 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 5.0 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 7.7 | PID_RHOA_PATHWAY | RhoA signaling pathway |
| 0.1 | 3.9 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 3.3 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 8.3 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.1 | 4.9 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.3 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 1.7 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.5 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 1.8 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.6 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.8 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.2 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 2.6 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.1 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.2 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
| 0.0 | 0.3 | PID_VEGFR1_PATHWAY | VEGFR1 specific signals |
| 0.0 | 1.1 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.4 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.2 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.9 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.5 | 6.4 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.4 | 16.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.4 | 7.7 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.3 | 9.5 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.3 | 23.9 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 12.0 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.3 | 2.3 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.2 | 5.7 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 7.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 8.7 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 1.1 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 3.3 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 3.9 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.3 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 1.3 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 5.7 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 4.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.5 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.1 | 2.5 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 0.7 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.3 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.7 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.9 | REACTOME_CIRCADIAN_CLOCK | Genes involved in Circadian Clock |
| 0.0 | 0.4 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 1.2 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.9 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.1 | REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 | Genes involved in ADP signalling through P2Y purinoceptor 1 |
| 0.0 | 0.4 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 1.1 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.9 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.7 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.4 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.2 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.4 | REACTOME_MRNA_PROCESSING | Genes involved in mRNA Processing |
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