Motif ID: Tfdp1_Wt1_Egr2

Z-value: 2.412

Transcription factors associated with Tfdp1_Wt1_Egr2:

Gene SymbolEntrez IDGene Name
Egr2 ENSMUSG00000037868.9 Egr2
Tfdp1 ENSMUSG00000038482.10 Tfdp1
Wt1 ENSMUSG00000016458.7 Wt1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfdp1mm10_v2_chr8_+_13339656_133396740.771.9e-04Click!
Egr2mm10_v2_chr10_+_67537861_67537930-0.503.3e-02Click!


Activity profile for motif Tfdp1_Wt1_Egr2.

activity profile for motif Tfdp1_Wt1_Egr2


Sorted Z-values histogram for motif Tfdp1_Wt1_Egr2

Sorted Z-values for motif Tfdp1_Wt1_Egr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfdp1_Wt1_Egr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 7.345 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr5_-_22344690 6.661 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr9_+_107400043 6.373 ENSMUST00000166799.1
ENSMUST00000170737.1
 Cacna2d2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

chr13_-_29984219 5.891 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr14_+_122475397 5.541 ENSMUST00000075888.5
 Zic2
zinc finger protein of the cerebellum 2
chr9_+_107399858 5.524 ENSMUST00000085092.5
ENSMUST00000164988.2
 Cacna2d2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

chr14_+_25607797 5.481 ENSMUST00000160229.1
 Zmiz1
zinc finger, MIZ-type containing 1
chr9_-_44234014 5.157 ENSMUST00000037644.6
 Cbl
Casitas B-lineage lymphoma
chr11_-_68386821 4.961 ENSMUST00000021284.3
 Ntn1
netrin 1
chr13_+_48261427 4.856 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr2_-_156839790 4.791 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
 Gm14230


predicted gene 14230


chr9_-_119578981 4.652 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr2_+_71786923 4.523 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr6_-_38876163 4.386 ENSMUST00000161779.1
 Hipk2
homeodomain interacting protein kinase 2
chr12_+_110279228 4.379 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr11_-_12037391 4.225 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr16_+_35983424 4.158 ENSMUST00000173555.1
 Kpna1
karyopherin (importin) alpha 1
chr6_+_4747306 4.074 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr12_-_108275409 4.070 ENSMUST00000136175.1
 Ccdc85c
coiled-coil domain containing 85C
chr2_-_102186322 3.979 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,341 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.9 GO:0038092 nodal signaling pathway(GO:0038092)
1.2 11.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.8 10.7 GO:0060024 rhythmic synaptic transmission(GO:0060024)
1.1 10.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 10.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
2.0 9.8 GO:2000382 positive regulation of mesoderm development(GO:2000382)
1.4 9.6 GO:0007296 vitellogenesis(GO:0007296)
1.1 8.6 GO:0033564 anterior/posterior axon guidance(GO:0033564)
2.0 8.0 GO:0003360 brainstem development(GO:0003360)
0.8 7.9 GO:0003263 cardioblast proliferation(GO:0003263) regulation of cardioblast proliferation(GO:0003264)
2.4 7.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.7 7.0 GO:0097477 lateral motor column neuron migration(GO:0097477)
1.1 6.9 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.2 6.8 GO:1902808 positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.7 6.7 GO:0008063 Toll signaling pathway(GO:0008063)
1.2 6.2 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.7 6.2 GO:0001842 neural fold formation(GO:0001842)
0.4 6.2 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.4 6.2 GO:0051639 actin filament network formation(GO:0051639)
1.0 6.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 443 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 27.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 22.3 GO:0005794 Golgi apparatus(GO:0005794)
0.3 21.2 GO:0005643 nuclear pore(GO:0005643)
0.2 15.7 GO:0031519 PcG protein complex(GO:0031519)
0.1 13.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 12.2 GO:0016607 nuclear speck(GO:0016607)
0.2 12.1 GO:0005811 lipid particle(GO:0005811)
0.1 11.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 11.4 GO:0016592 mediator complex(GO:0016592)
0.1 11.4 GO:0044853 plasma membrane raft(GO:0044853)
0.9 10.4 GO:0016600 flotillin complex(GO:0016600)
0.3 10.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 10.3 GO:0002102 podosome(GO:0002102)
0.4 8.1 GO:0016580 Sin3 complex(GO:0016580)
0.3 8.0 GO:0001741 XY body(GO:0001741)
0.1 7.7 GO:0031965 nuclear membrane(GO:0031965)
1.3 7.6 GO:0061689 tricellular tight junction(GO:0061689)
1.2 7.5 GO:0016011 dystroglycan complex(GO:0016011)
2.5 7.4 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 7.0 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 700 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 21.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 18.2 GO:0008270 zinc ion binding(GO:0008270)
0.1 16.8 GO:0045296 cadherin binding(GO:0045296)
0.5 16.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 14.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 11.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 10.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.6 10.0 GO:0070411 I-SMAD binding(GO:0070411)
0.4 10.0 GO:0043394 proteoglycan binding(GO:0043394)
1.2 9.8 GO:0046790 virion binding(GO:0046790)
0.5 8.7 GO:0003680 AT DNA binding(GO:0003680)
0.1 8.4 GO:0002039 p53 binding(GO:0002039)
1.4 8.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 8.2 GO:0005080 protein kinase C binding(GO:0005080)
0.1 8.2 GO:0001047 core promoter binding(GO:0001047)
0.2 7.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 7.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.0 7.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 7.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
1.5 7.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 29.4 PID_E2F_PATHWAY E2F transcription factor network
0.7 20.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 18.6 PID_IGF1_PATHWAY IGF1 pathway
0.2 17.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 16.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.4 16.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 14.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.3 14.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.5 13.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3 13.3 PID_BMP_PATHWAY BMP receptor signaling
0.1 12.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.5 11.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 11.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 10.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 9.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 9.0 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 9.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.3 8.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.2 8.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 7.2 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 21.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.7 14.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.5 14.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.6 13.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.4 12.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 11.9 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.4 11.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 10.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 10.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 9.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 9.5 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.4 9.0 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.8 8.9 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 8.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 8.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.5 7.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.6 7.7 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.5 7.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.3 7.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 7.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation