Motif ID: Smad2

Z-value: 0.725


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241580_76241741-0.841.6e-05Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Showing 1 to 20 of 68 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_87959560 2.719 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr14_-_12345847 2.666 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr9_-_119578981 2.144 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr7_-_116237767 1.907 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr19_+_59458372 1.599 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr16_+_64851991 1.445 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr8_-_105637403 1.320 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr3_+_127633134 1.232 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr13_-_78199757 1.157 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr10_-_37138863 1.145 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr4_+_11191726 1.127 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr8_-_90908415 1.036 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chr13_+_23752267 0.987 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr10_-_42583628 0.964 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr7_+_82867327 0.919 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr17_-_34615965 0.873 ENSMUST00000097345.3
ENSMUST00000015611.7
 Egfl8

EGF-like domain 8

chr8_-_105637350 0.849 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr6_-_55175019 0.800 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr15_-_103251465 0.770 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr14_-_31168587 0.714 ENSMUST00000036618.7
 Stab1
stabilin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.4 2.7 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 2.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.7 2.1 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.3 1.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 1.7 GO:0007129 synapsis(GO:0007129)
0.1 1.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.2 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 1.1 GO:0051764 actin crosslink formation(GO:0051764)
0.2 1.0 GO:0021764 amygdala development(GO:0021764)
0.0 1.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.9 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.8 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.6 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.5 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.4 GO:0000212 meiotic spindle organization(GO:0000212)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 1.9 GO:0005915 zonula adherens(GO:0005915)
0.6 1.7 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 1.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.4 1.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.4 GO:0005827 polar microtubule(GO:0005827)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 2.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 1.9 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 1.2 GO:0070888 E-box binding(GO:0070888)
0.0 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 0.8 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.2 0.6 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.3 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.9 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation