Motif ID: Lhx2_Hoxc5

Z-value: 0.572

Transcription factors associated with Lhx2_Hoxc5:

Gene SymbolEntrez IDGene Name
Hoxc5 ENSMUSG00000022485.3 Hoxc5
Lhx2 ENSMUSG00000000247.5 Lhx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx2mm10_v2_chr2_+_38341068_38341092-0.165.3e-01Click!


Activity profile for motif Lhx2_Hoxc5.

activity profile for motif Lhx2_Hoxc5


Sorted Z-values histogram for motif Lhx2_Hoxc5

Sorted Z-values for motif Lhx2_Hoxc5



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_170009892 1.422 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr12_+_116275386 1.205 ENSMUST00000090195.4
 Gm11027
predicted gene 11027
chr5_-_106926245 1.123 ENSMUST00000117588.1
 Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chrM_+_10167 1.030 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr4_-_155645408 0.924 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chrY_+_90785442 0.817 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chr4_-_14621805 0.776 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr12_-_87444017 0.754 ENSMUST00000091090.4
 2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr7_-_5413145 0.753 ENSMUST00000108569.2
 Vmn1r58
vomeronasal 1 receptor 58
chr13_+_44121167 0.738 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr1_+_170308802 0.686 ENSMUST00000056991.5
 1700015E13Rik
RIKEN cDNA 1700015E13 gene
chr5_-_62766153 0.678 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr17_+_17316078 0.662 ENSMUST00000105311.3
 Gm6712
predicted gene 6712
chr2_-_180954620 0.662 ENSMUST00000139929.1
 Nkain4
Na+/K+ transporting ATPase interacting 4
chr12_-_84617326 0.647 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr4_+_147132038 0.639 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chrX_+_103356464 0.613 ENSMUST00000116547.2
 Chic1
cysteine-rich hydrophobic domain 1
chr16_+_65520503 0.611 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
 Pou1f1


POU domain, class 1, transcription factor 1


chr9_+_25089422 0.597 ENSMUST00000086238.2
 Gm10181
predicted gene 10181
chrY_+_90784738 0.591 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0019532 oxalate transport(GO:0019532)
0.1 1.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.2 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 1.1 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.2 0.6 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.1 0.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.6 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.2 0.5 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.2 0.5 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 0.4 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.4 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 0.3 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.5 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.4 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 1.2 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.6 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 0.5 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.4 GO:0004568 chitinase activity(GO:0004568)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.3 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.1 0.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.2 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.2 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.1 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins