Motif ID: Gfi1_Gfi1b

Z-value: 1.439

Transcription factors associated with Gfi1_Gfi1b:

Gene SymbolEntrez IDGene Name
Gfi1 ENSMUSG00000029275.11 Gfi1
Gfi1b ENSMUSG00000026815.8 Gfi1b



Activity profile for motif Gfi1_Gfi1b.

activity profile for motif Gfi1_Gfi1b


Sorted Z-values histogram for motif Gfi1_Gfi1b

Sorted Z-values for motif Gfi1_Gfi1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Gfi1_Gfi1b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 10.162 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_26989974 9.043 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr7_+_62376979 5.039 ENSMUST00000080403.5
 Magel2
melanoma antigen, family L, 2
chr11_-_84525514 3.897 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr9_+_3005125 3.865 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr13_+_35659856 3.801 ENSMUST00000075220.6
 Cdyl
chromodomain protein, Y chromosome-like
chr9_+_3000922 3.718 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr16_+_92498122 3.640 ENSMUST00000023670.3
 Clic6
chloride intracellular channel 6
chr9_+_3027439 3.633 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3034599 3.406 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3013140 3.373 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr7_-_17062384 3.264 ENSMUST00000153833.1
ENSMUST00000108492.2
 Hif3a

hypoxia inducible factor 3, alpha subunit

chr9_+_3015654 2.944 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3025417 2.939 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3023547 2.933 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3017408 2.927 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr7_-_62464505 2.926 ENSMUST00000094339.2
 Peg12
paternally expressed 12
chr7_-_99353104 2.892 ENSMUST00000169437.1
ENSMUST00000094154.4
 Serpinh1

serine (or cysteine) peptidase inhibitor, clade H, member 1

chr17_-_70849644 2.840 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr11_+_84525669 2.734 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.5 GO:0006270 DNA replication initiation(GO:0006270)
1.7 10.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.6 6.2 GO:2000768 positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.4 5.1 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 4.6 GO:1902476 chloride transmembrane transport(GO:1902476)
1.0 3.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.4 2.9 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.1 2.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 2.9 GO:0000578 embryonic axis specification(GO:0000578)
0.2 2.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 2.7 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.8 2.5 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 2.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 2.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 2.0 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 2.0 GO:0043029 T cell homeostasis(GO:0043029)
0.0 2.0 GO:0021884 forebrain neuron development(GO:0021884)
0.2 1.9 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 1.8 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 1.8 GO:0008360 regulation of cell shape(GO:0008360)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.2 GO:0016607 nuclear speck(GO:0016607)
0.1 5.0 GO:0030904 retromer complex(GO:0030904)
0.0 4.4 GO:0000776 kinetochore(GO:0000776)
0.1 3.6 GO:0034707 chloride channel complex(GO:0034707)
1.0 3.0 GO:0005588 collagen type V trimer(GO:0005588)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.8 2.3 GO:0071914 prominosome(GO:0071914)
0.1 2.3 GO:0002102 podosome(GO:0002102)
0.3 1.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 1.7 GO:0001520 outer dense fiber(GO:0001520) meiotic spindle(GO:0072687)
0.1 1.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.4 GO:0045120 pronucleus(GO:0045120)
0.0 1.4 GO:0016592 mediator complex(GO:0016592)
0.0 1.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.3 GO:0035326 enhancer binding(GO:0035326)
0.0 4.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 4.1 GO:0003682 chromatin binding(GO:0003682)
0.1 3.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
1.2 3.6 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.0 3.6 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.8 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.8 GO:0042805 actinin binding(GO:0042805)
0.0 2.8 GO:0051015 actin filament binding(GO:0051015)
0.5 2.7 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 2.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 2.5 GO:0016015 morphogen activity(GO:0016015)
0.0 2.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.2 2.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.0 GO:0003714 transcription corepressor activity(GO:0003714)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 3.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.0 NABA_COLLAGENS Genes encoding collagen proteins
0.2 2.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.0 0.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.6 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.5 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 0.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 4.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.3 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 3.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.3 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 2.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 1.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.3 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis