Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.413

Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6:

Gene SymbolEntrez IDGene Name
Barx1 ENSMUSG00000021381.4 Barx1
Dlx6 ENSMUSG00000029754.7 Dlx6
Lhx9 ENSMUSG00000019230.8 Lhx9
Msx1 ENSMUSG00000048450.10 Msx1
Rax ENSMUSG00000024518.3 Rax

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx9mm10_v2_chr1_-_138847579_138847719-0.644.2e-03Click!
Msx1mm10_v2_chr5_-_37824580_37824584-0.591.0e-02Click!
Dlx6mm10_v2_chr6_+_6863769_6863797-0.455.9e-02Click!
Raxmm10_v2_chr18_-_65939048_65939089-0.116.6e-01Click!


Activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6.

activity profile for motif Msx1_Lhx9_Barx1_Rax_Dlx6


Sorted Z-values histogram for motif Msx1_Lhx9_Barx1_Rax_Dlx6

Sorted Z-values for motif Msx1_Lhx9_Barx1_Rax_Dlx6



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Top targets:


Showing 1 to 20 of 176 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_136171722 1.870 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr18_+_23415400 1.490 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr5_-_62766153 1.248 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_155417394 1.246 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr16_+_45093611 1.221 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr9_-_40346290 1.064 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr19_+_26749726 0.976 ENSMUST00000175842.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr16_+_42907563 0.974 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr1_+_104768510 0.972 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr12_-_83487708 0.841 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr1_-_155417283 0.826 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr8_+_54954728 0.822 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr10_+_39612934 0.774 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr5_-_134747241 0.741 ENSMUST00000015138.9
 Eln
elastin
chr4_-_14621805 0.737 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr3_+_68572245 0.719 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr13_+_44121167 0.712 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr7_+_126950518 0.705 ENSMUST00000106335.1
ENSMUST00000146017.1
 Sez6l2

seizure related 6 homolog like 2

chr10_-_25200110 0.703 ENSMUST00000100012.2
 Akap7
A kinase (PRKA) anchor protein 7
chr18_-_37969742 0.696 ENSMUST00000166148.1
ENSMUST00000163131.1
ENSMUST00000043437.7
 Fchsd1


FCH and double SH3 domains 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.5 1.9 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 1.8 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.2 1.6 GO:0019532 oxalate transport(GO:0019532)
0.1 1.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.2 0.7 GO:0050975 sensory perception of touch(GO:0050975)
0.1 0.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.7 GO:0001553 luteinization(GO:0001553)
0.0 0.7 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.2 0.5 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 0.5 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.4 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.4 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 0.3 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 0.3 GO:0043490 malate-aspartate shuttle(GO:0043490)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0071565 nBAF complex(GO:0071565)
0.1 1.9 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.2 GO:0005614 interstitial matrix(GO:0005614)
0.2 0.7 GO:0071953 elastic fiber(GO:0071953)
0.0 0.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.4 GO:0030673 axolemma(GO:0030673)
0.1 0.3 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 1.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 1.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 1.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.7 GO:0016208 AMP binding(GO:0016208)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.5 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.1 PID_EPHA_FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis