Motif ID: Atf1_Creb5
Z-value: 0.951
Transcription factors associated with Atf1_Creb5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Atf1 | ENSMUSG00000023027.6 | Atf1 |
| Creb5 | ENSMUSG00000053007.6 | Creb5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Atf1 | mm10_v2_chr15_+_100228229_100228280 | -0.19 | 4.6e-01 | Click! |
| Creb5 | mm10_v2_chr6_+_53573364_53573394 | -0.01 | 9.5e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 147 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.0 | 3.6 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.2 | 3.5 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.4 | 3.0 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.2 | 2.6 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) |
| 0.1 | 2.6 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.1 | 2.2 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.3 | 2.0 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.0 | 2.0 | GO:0008542 | visual learning(GO:0008542) |
| 0.3 | 1.7 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
| 0.0 | 1.5 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 0.0 | 1.4 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.3 | 1.3 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.3 | 1.3 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.0 | 1.3 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 1.3 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.2 | 1.2 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.1 | 1.2 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 1.2 | GO:0051591 | response to cAMP(GO:0051591) |
| 0.3 | 1.1 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 64 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 3.5 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 2.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 2.0 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 1.9 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 1.8 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 1.6 | GO:0043679 | axon terminus(GO:0043679) |
| 0.1 | 1.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 1.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 1.4 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 1.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.1 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 1.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.1 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 1.0 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 1.0 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 0.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 0.8 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.1 | 0.8 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 0.8 | GO:0031430 | M band(GO:0031430) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 94 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 4.3 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 4.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 3.8 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.1 | 3.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 2.5 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 2.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 2.3 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.1 | 2.2 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.4 | 2.0 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 1.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 1.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 1.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 1.4 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 1.4 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 1.4 | GO:0051213 | dioxygenase activity(GO:0051213) |
| 0.3 | 1.3 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.2 | 1.3 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.1 | 1.3 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 1.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 23 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.1 | 3.9 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 3.2 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 3.0 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 2.3 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 2.0 | PID_GMCSF_PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 1.4 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.3 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.2 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.2 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 1.1 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.8 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.6 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.6 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.6 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 0.5 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.5 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.4 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.3 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.3 | PID_RAS_PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 33 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 3.0 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.1 | 2.8 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 2.6 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.2 | 1.8 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 1.5 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 1.4 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 1.4 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.4 | REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 1.3 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 1.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.2 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 1.2 | REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER | Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| 0.0 | 1.1 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.0 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 0.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PC | Genes involved in Acyl chain remodelling of PC |
| 0.0 | 0.8 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.7 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.6 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
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