Motif ID: Dlx5_Dlx4
Z-value: 1.007
Transcription factors associated with Dlx5_Dlx4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Dlx4 | ENSMUSG00000020871.7 | Dlx4 |
| Dlx5 | ENSMUSG00000029755.9 | Dlx5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dlx5 | mm10_v2_chr6_-_6882068_6882092 | 0.07 | 7.9e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 188 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.6 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 5.5 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.2 | 3.6 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.1 | 2.8 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 2.7 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.1 | 2.6 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.1 | 2.5 | GO:0000578 | embryonic axis specification(GO:0000578) |
| 0.2 | 2.3 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
| 0.0 | 2.3 | GO:0042491 | auditory receptor cell differentiation(GO:0042491) |
| 0.0 | 2.1 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.7 | 2.0 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.1 | 2.0 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.1 | 1.9 | GO:0071385 | cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.4 | 1.8 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 1.7 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.0 | 1.7 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.4 | 1.5 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.2 | 1.5 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.5 | 1.4 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.3 | 1.4 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 94 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 6.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 4.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 3.1 | GO:0005657 | replication fork(GO:0005657) |
| 0.5 | 2.3 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.0 | 2.2 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.5 | 2.1 | GO:0008623 | CHRAC(GO:0008623) |
| 0.1 | 2.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.5 | 2.0 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 0.5 | 1.5 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.1 | 1.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 1.5 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.0 | 1.4 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 1.3 | GO:0032797 | SMN complex(GO:0032797) |
| 0.0 | 1.3 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 0.0 | 1.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 0.9 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.1 | 0.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 123 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 4.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 2.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 2.4 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.0 | 1.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 1.8 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 1.8 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 1.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 1.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 1.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.5 | 1.5 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.1 | 1.5 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.1 | 1.5 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 1.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.5 | 1.4 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.0 | 1.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 1.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.3 | 1.2 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.0 | 1.2 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.1 | 1.1 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 33 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.9 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 2.8 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 2.0 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 1.3 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.0 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 1.0 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.0 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.9 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 0.9 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.8 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 0.7 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.6 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.6 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.6 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.5 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.5 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.5 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 54 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 2.4 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 2.0 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.9 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.8 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.6 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.5 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 1.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 1.5 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 1.2 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 1.2 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.0 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.0 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.9 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.9 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.9 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.8 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.8 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.8 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
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