Motif ID: Pou6f2_Pou4f2

Z-value: 0.534

Transcription factors associated with Pou6f2_Pou4f2:

Gene SymbolEntrez IDGene Name
Pou4f2 ENSMUSG00000031688.3 Pou4f2
Pou6f2 ENSMUSG00000009734.11 Pou6f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou6f2mm10_v2_chr13_-_18382041_18382041-0.503.7e-02Click!
Pou4f2mm10_v2_chr8_-_78436640_784366490.233.6e-01Click!


Activity profile for motif Pou6f2_Pou4f2.

activity profile for motif Pou6f2_Pou4f2


Sorted Z-values histogram for motif Pou6f2_Pou4f2

Sorted Z-values for motif Pou6f2_Pou4f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou6f2_Pou4f2

PNG image of the network

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Top targets:


Showing 1 to 20 of 103 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 1.834 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr1_+_153665666 1.654 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr1_+_153665274 1.653 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr12_-_56535047 1.603 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr2_+_109917639 1.388 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr1_+_153665587 1.327 ENSMUST00000147700.1
 Rgs8
regulator of G-protein signaling 8
chr4_-_58499398 1.200 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr1_+_153665627 1.196 ENSMUST00000147482.1
 Rgs8
regulator of G-protein signaling 8
chr7_-_49636847 1.189 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr3_-_154328634 1.110 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr2_-_168767029 1.070 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr13_-_56296551 0.915 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr6_-_138426735 0.881 ENSMUST00000162932.1
 Lmo3
LIM domain only 3
chr10_-_92164666 0.860 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr2_-_168767136 0.829 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr14_+_27039001 0.826 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr8_-_61902669 0.785 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr2_+_132847719 0.760 ENSMUST00000124836.1
ENSMUST00000154160.1
 Crls1

cardiolipin synthase 1

chr3_+_55782500 0.713 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr13_-_81570640 0.653 ENSMUST00000109565.2
 Gpr98
G protein-coupled receptor 98

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.8 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 1.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 1.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.5 1.6 GO:0021759 globus pallidus development(GO:0021759)
0.5 1.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 1.2 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 1.2 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 1.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.3 0.9 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.1 0.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.8 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.8 GO:0021884 forebrain neuron development(GO:0021884)
0.1 0.5 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 0.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.4 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.4 GO:0060032 notochord regression(GO:0060032)
0.1 0.4 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.4 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.9 GO:0000792 heterochromatin(GO:0000792)
0.0 1.2 GO:0043198 dendritic shaft(GO:0043198)
0.2 1.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.1 0.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.0 GO:0044302 dentate gyrus mossy fiber(GO:0044302)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.9 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.9 GO:0008009 chemokine activity(GO:0008009)
0.3 0.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.8 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 0.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.4 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0019865 immunoglobulin binding(GO:0019865)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells