Motif ID: Scrt2

Z-value: 1.415


Transcription factors associated with Scrt2:

Gene SymbolEntrez IDGene Name
Scrt2 ENSMUSG00000060257.2 Scrt2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Scrt2mm10_v2_chr2_+_152081529_152081624-0.474.6e-02Click!


Activity profile for motif Scrt2.

activity profile for motif Scrt2


Sorted Z-values histogram for motif Scrt2

Sorted Z-values for motif Scrt2



Network of associatons between targets according to the STRING database.



First level regulatory network of Scrt2

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_30973399 7.460 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr7_-_30973367 6.992 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973464 6.941 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr10_+_26229707 6.789 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr10_+_56377300 6.785 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr9_+_91368811 5.980 ENSMUST00000173054.1
 Zic4
zinc finger protein of the cerebellum 4
chr9_+_91368970 5.203 ENSMUST00000172646.1
 Zic4
zinc finger protein of the cerebellum 4
chr7_-_25250720 3.631 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chrX_-_72274747 3.545 ENSMUST00000064780.3
 Gabre
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr9_-_27155418 3.527 ENSMUST00000167074.1
ENSMUST00000034472.8
 Jam3

junction adhesion molecule 3

chr15_-_98004634 3.395 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr3_+_34649987 3.318 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr2_-_164443177 3.259 ENSMUST00000017153.3
 Sdc4
syndecan 4
chr13_+_23756937 3.256 ENSMUST00000102965.2
 Hist1h4b
histone cluster 1, H4b
chr3_-_33143227 3.220 ENSMUST00000108219.1
 Pex5l
peroxisomal biogenesis factor 5-like
chr2_+_31950257 3.209 ENSMUST00000001920.7
 Aif1l
allograft inflammatory factor 1-like
chr8_+_31187317 2.827 ENSMUST00000066173.5
ENSMUST00000161788.1
ENSMUST00000110527.2
ENSMUST00000161502.1
 Fut10



fucosyltransferase 10



chr1_-_133424377 2.771 ENSMUST00000153799.1
 Sox13
SRY-box containing gene 13
chr16_+_16213318 2.768 ENSMUST00000162150.1
ENSMUST00000161342.1
ENSMUST00000039408.2
 Pkp2


plakophilin 2


chr11_-_100355383 2.540 ENSMUST00000146878.2
 Hap1
huntingtin-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.1 21.4 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.6 6.9 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
2.3 6.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.8 5.4 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.7 3.6 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.4 3.5 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 3.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 3.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.7 3.3 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.5 3.3 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.2 3.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 3.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.9 2.8 GO:0002159 desmosome assembly(GO:0002159) adherens junction maintenance(GO:0034334) intermediate filament bundle assembly(GO:0045110) maintenance of organ identity(GO:0048496)
0.2 2.8 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.2 2.8 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 2.8 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.5 2.5 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.4 2.4 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.5 2.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 2.2 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 21.4 GO:0061689 tricellular tight junction(GO:0061689)
0.6 6.8 GO:0005916 fascia adherens(GO:0005916)
1.3 5.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 4.5 GO:0016607 nuclear speck(GO:0016607)
0.1 4.0 GO:0043034 costamere(GO:0043034)
0.0 3.9 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 3.7 GO:0005814 centriole(GO:0005814)
0.7 3.5 GO:0033010 paranodal junction(GO:0033010)
0.3 3.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 3.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 2.8 GO:0030057 desmosome(GO:0030057)
0.0 2.4 GO:0005581 collagen trimer(GO:0005581)
0.1 2.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.5 2.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.5 GO:0042734 presynaptic membrane(GO:0042734)
0.2 1.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.4 GO:0042555 MCM complex(GO:0042555)
0.0 1.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 21.4 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 17.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 8.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
1.7 6.8 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
1.1 5.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 4.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 3.8 GO:0035198 miRNA binding(GO:0035198)
0.1 3.8 GO:0005518 collagen binding(GO:0005518)
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 3.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 3.5 GO:0005178 integrin binding(GO:0005178)
0.7 3.4 GO:0042289 MHC class II protein binding(GO:0042289)
1.6 3.3 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.7 2.8 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 2.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 2.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 2.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.8 2.4 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 2.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 2.3 GO:0008266 poly(U) RNA binding(GO:0008266)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 6.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 5.8 NABA_COLLAGENS Genes encoding collagen proteins
0.3 3.5 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 2.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.7 6.9 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.6 6.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 3.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 3.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 2.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.8 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis