Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 1.752

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six5mm10_v2_chr7_+_19094594_190946330.409.9e-02Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.322.0e-01Click!
Zfp143mm10_v2_chr7_+_110061702_1100617320.292.5e-01Click!
Smarcc2mm10_v2_chr10_+_128459236_1284592480.097.2e-01Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_44997221 1.964 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)
chr7_-_44997535 1.750 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr14_+_64950037 1.697 ENSMUST00000043914.5
 Ints9
integrator complex subunit 9
chr7_+_12897800 1.596 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr17_+_80127447 1.451 ENSMUST00000039205.4
 Galm
galactose mutarotase
chr7_+_19024387 1.391 ENSMUST00000153976.1
 Sympk
symplekin
chr2_+_118598209 1.339 ENSMUST00000038341.7
 Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
chr4_-_116708312 1.334 ENSMUST00000030453.4
 Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr5_+_24423851 1.312 ENSMUST00000141966.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr14_-_64949632 1.301 ENSMUST00000176832.1
 Hmbox1
homeobox containing 1
chr5_-_149636331 1.109 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1



chr11_+_4704642 1.044 ENSMUST00000009220.4
 Zmat5
zinc finger, matrin type 5
chr5_-_5514730 1.022 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr5_-_134314378 0.992 ENSMUST00000174867.1
 Gtf2i
general transcription factor II I
chr1_+_131867224 0.992 ENSMUST00000112386.1
ENSMUST00000027693.7
 Rab7l1

RAB7, member RAS oncogene family-like 1

chr7_+_13278778 0.986 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chr5_-_33657889 0.966 ENSMUST00000019439.7
 Tmem129
transmembrane protein 129
chr14_-_64949838 0.948 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
 Hmbox1





homeobox containing 1





chr5_-_5514873 0.946 ENSMUST00000060947.7
 Cldn12
claudin 12
chr10_-_81407641 0.936 ENSMUST00000140916.1
 Nfic
nuclear factor I/C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 288 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.4 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.5 2.7 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 2.5 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.0 2.3 GO:0006821 chloride transport(GO:0006821)
0.1 2.2 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 2.2 GO:0016180 snRNA processing(GO:0016180)
0.3 1.9 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 1.9 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.1 1.8 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 1.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.3 1.5 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.5 1.4 GO:0036292 DNA rewinding(GO:0036292)
0.4 1.3 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.3 1.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 1.2 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 1.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 1.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.3 1.1 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)
0.1 1.1 GO:0042148 strand invasion(GO:0042148)
0.1 1.1 GO:0090435 protein localization to nuclear envelope(GO:0090435)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0016324 apical plasma membrane(GO:0016324)
0.0 2.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 2.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 2.4 GO:0043596 nuclear replication fork(GO:0043596)
0.2 2.2 GO:0097165 nuclear stress granule(GO:0097165)
0.1 1.7 GO:0032039 integrator complex(GO:0032039)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.1 1.6 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.5 GO:0016592 mediator complex(GO:0016592)
0.0 1.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 1.3 GO:0005818 aster(GO:0005818)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 1.2 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.0 1.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.2 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2 1.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 1.0 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 2.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 2.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 2.1 GO:0036310 annealing helicase activity(GO:0036310)
0.1 2.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.0 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.3 1.9 GO:0031419 cobalamin binding(GO:0031419)
0.0 1.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 1.5 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2 1.4 GO:0048256 flap endonuclease activity(GO:0048256)
0.2 1.4 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 1.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 1.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 1.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.2 1.1 GO:0000150 recombinase activity(GO:0000150)
0.1 1.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 1.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.8 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 0.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.6 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.2 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.5 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.6 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 1.5 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 1.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 1.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 0.9 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.9 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.7 REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.7 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.7 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway