Motif ID: Hoxa4
Z-value: 0.863
Transcription factors associated with Hoxa4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxa4 | ENSMUSG00000000942.10 | Hoxa4 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.7 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
0.8 | 2.3 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
0.7 | 8.0 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.6 | 1.8 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.5 | 6.0 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
0.3 | 2.6 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
0.3 | 1.3 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
0.3 | 0.9 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
0.3 | 1.7 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
0.3 | 1.3 | GO:0046684 | response to pyrethroid(GO:0046684) |
0.2 | 1.2 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
0.2 | 1.6 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
0.2 | 0.7 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
0.1 | 0.6 | GO:0002674 | negative regulation of acute inflammatory response(GO:0002674) |
0.1 | 1.9 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
0.1 | 0.8 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
0.1 | 5.7 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
0.1 | 0.5 | GO:0030901 | midbrain development(GO:0030901) |
0.1 | 1.4 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
0.1 | 0.4 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
0.1 | 0.7 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
0.1 | 0.8 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
0.1 | 0.5 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.1 | 0.9 | GO:0043084 | penile erection(GO:0043084) |
0.1 | 1.4 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.1 | 0.7 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.1 | 0.7 | GO:1903301 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
0.1 | 0.7 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
0.1 | 1.3 | GO:0007614 | short-term memory(GO:0007614) |
0.1 | 4.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.1 | 0.2 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
0.1 | 0.2 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
0.1 | 1.5 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.1 | 0.4 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
0.1 | 1.5 | GO:0070207 | protein homotrimerization(GO:0070207) |
0.0 | 3.9 | GO:0030032 | lamellipodium assembly(GO:0030032) |
0.0 | 0.5 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
0.0 | 0.4 | GO:0086023 | adrenergic receptor signaling pathway involved in heart process(GO:0086023) |
0.0 | 0.5 | GO:0044144 | regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144) |
0.0 | 0.7 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
0.0 | 0.3 | GO:0051775 | response to redox state(GO:0051775) |
0.0 | 0.2 | GO:0006751 | glutathione catabolic process(GO:0006751) |
0.0 | 0.5 | GO:0046548 | retinal rod cell development(GO:0046548) |
0.0 | 0.3 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.0 | 0.6 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
0.0 | 0.4 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
0.0 | 0.2 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
0.0 | 0.4 | GO:0032570 | response to progesterone(GO:0032570) |
0.0 | 0.1 | GO:0021502 | neural fold elevation formation(GO:0021502) |
0.0 | 0.3 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
0.0 | 0.1 | GO:0019695 | choline metabolic process(GO:0019695) |
0.0 | 0.8 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
0.0 | 0.4 | GO:0051382 | kinetochore assembly(GO:0051382) |
0.0 | 1.1 | GO:0006376 | mRNA splice site selection(GO:0006376) |
0.0 | 0.6 | GO:0048665 | neuron fate specification(GO:0048665) |
0.0 | 0.1 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
0.0 | 0.3 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
0.0 | 0.3 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
0.0 | 0.2 | GO:0042574 | isoprenoid catabolic process(GO:0008300) retinal metabolic process(GO:0042574) |
0.0 | 0.4 | GO:0001553 | luteinization(GO:0001553) |
0.0 | 0.4 | GO:1903963 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
0.0 | 0.2 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
0.0 | 0.7 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
0.0 | 0.6 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
0.0 | 1.8 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
0.0 | 0.2 | GO:0006953 | acute-phase response(GO:0006953) |
0.0 | 0.7 | GO:0030835 | negative regulation of actin filament depolymerization(GO:0030835) |
0.0 | 0.1 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) monocyte aggregation(GO:0070487) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
0.0 | 0.3 | GO:0050995 | negative regulation of lipid catabolic process(GO:0050995) |
0.0 | 0.7 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
0.0 | 0.2 | GO:0046085 | adenosine metabolic process(GO:0046085) |
0.0 | 1.2 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.0 | 0.5 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
0.0 | 0.7 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
0.0 | 0.5 | GO:2001222 | regulation of neuron migration(GO:2001222) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 2.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
0.4 | 2.5 | GO:0044308 | axonal spine(GO:0044308) |
0.4 | 1.5 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
0.2 | 3.4 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.1 | 1.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.1 | 1.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.1 | 0.3 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
0.1 | 0.5 | GO:0097524 | sperm plasma membrane(GO:0097524) |
0.1 | 0.7 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
0.1 | 0.3 | GO:0032437 | cuticular plate(GO:0032437) |
0.0 | 0.4 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
0.0 | 0.2 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
0.0 | 2.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.0 | 0.6 | GO:0044232 | organelle membrane contact site(GO:0044232) |
0.0 | 5.1 | GO:0042641 | actomyosin(GO:0042641) |
0.0 | 0.7 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 0.5 | GO:0051286 | cell tip(GO:0051286) |
0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 0.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.0 | 0.3 | GO:0005614 | interstitial matrix(GO:0005614) |
0.0 | 2.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.0 | 0.9 | GO:0030667 | secretory granule membrane(GO:0030667) |
0.0 | 0.1 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
0.0 | 1.2 | GO:0005814 | centriole(GO:0005814) |
0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 0.3 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 8.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.8 | 5.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.8 | 2.3 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
0.2 | 1.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.2 | 1.6 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.2 | 0.8 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
0.2 | 1.3 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
0.1 | 1.7 | GO:0038191 | neuropilin binding(GO:0038191) |
0.1 | 0.7 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.1 | 0.6 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
0.1 | 1.2 | GO:0050897 | cobalt ion binding(GO:0050897) |
0.1 | 1.8 | GO:0030275 | LRR domain binding(GO:0030275) |
0.1 | 0.7 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
0.1 | 0.4 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
0.1 | 0.4 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
0.1 | 1.3 | GO:0031402 | sodium ion binding(GO:0031402) |
0.0 | 1.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.9 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 1.2 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
0.0 | 0.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.0 | 1.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.8 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.0 | 1.0 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.0 | 0.2 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
0.0 | 0.6 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.0 | 0.9 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
0.0 | 0.5 | GO:0015248 | sterol transporter activity(GO:0015248) |
0.0 | 1.0 | GO:0005158 | insulin receptor binding(GO:0005158) |
0.0 | 1.5 | GO:0036002 | pre-mRNA binding(GO:0036002) |
0.0 | 0.1 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
0.0 | 1.8 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 1.5 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
0.0 | 0.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
0.0 | 0.1 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.0 | 0.1 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.0 | 0.4 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
0.0 | 0.4 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
0.0 | 0.4 | GO:0050681 | androgen receptor binding(GO:0050681) |
0.0 | 0.3 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
0.0 | 0.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.1 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.0 | 0.2 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
0.0 | 0.3 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
0.0 | 0.7 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.3 | GO:0030506 | ankyrin binding(GO:0030506) |
0.0 | 0.2 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.0 | 2.4 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
0.0 | 4.5 | GO:0003779 | actin binding(GO:0003779) |
0.0 | 0.3 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.0 | 0.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 5.7 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.1 | 7.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.1 | 3.4 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.1 | 2.3 | PID_HIV_NEF_PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
0.1 | 1.4 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.0 | 2.5 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.0 | 0.2 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.0 | 0.9 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
0.0 | 0.9 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
0.0 | 0.4 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.0 | 0.4 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
0.0 | 0.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 0.4 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 1.0 | PID_CDC42_PATHWAY | CDC42 signaling events |
0.0 | 0.7 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
0.0 | 0.4 | PID_FGF_PATHWAY | FGF signaling pathway |
0.0 | 1.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.5 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
0.0 | 0.3 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 0.4 | PID_SHP2_PATHWAY | SHP2 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.6 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
0.3 | 1.5 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.2 | 5.9 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.2 | 2.3 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.1 | 3.9 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.1 | 1.6 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
0.1 | 0.9 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.0 | 0.4 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
0.0 | 1.8 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 1.1 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
0.0 | 0.8 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
0.0 | 0.7 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
0.0 | 1.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 0.4 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
0.0 | 0.2 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.0 | 0.3 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 0.5 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
0.0 | 0.4 | REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
0.0 | 1.0 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
0.0 | 0.5 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.5 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |