Motif ID: Hoxa4

Z-value: 0.863


Transcription factors associated with Hoxa4:

Gene SymbolEntrez IDGene Name
Hoxa4 ENSMUSG00000000942.10 Hoxa4



Activity profile for motif Hoxa4.

activity profile for motif Hoxa4


Sorted Z-values histogram for motif Hoxa4

Sorted Z-values for motif Hoxa4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa4

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_80802789 3.439 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr4_+_144892813 3.319 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_+_71528657 2.748 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr4_+_144893077 2.685 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr18_-_31949571 2.571 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17
chr7_-_19699008 2.271 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr4_+_144893127 2.247 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr14_-_79771305 2.166 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr4_+_119814495 2.001 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr12_+_38780284 1.995 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr12_+_38780817 1.858 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr2_-_77519565 1.833 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr5_+_17574726 1.679 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr2_+_70563435 1.605 ENSMUST00000123330.1
 Gad1
glutamate decarboxylase 1
chr3_+_86070915 1.431 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr2_+_170731807 1.407 ENSMUST00000029075.4
 Dok5
docking protein 5
chr2_-_65529275 1.292 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr5_-_122002340 1.287 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr14_-_30353468 1.257 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr11_+_57011945 1.251 ENSMUST00000094179.4
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.0 GO:0042572 retinol metabolic process(GO:0042572)
0.5 6.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 5.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 4.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.9 2.7 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.3 2.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.8 2.3 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.1 1.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.6 1.8 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 1.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.3 1.7 GO:0003350 pulmonary myocardium development(GO:0003350)
0.2 1.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 1.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 1.5 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.4 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 1.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 1.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.3 1.3 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.3 GO:0007614 short-term memory(GO:0007614)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0042641 actomyosin(GO:0042641)
0.2 3.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 2.6 GO:0031225 anchored component of membrane(GO:0031225)
0.4 2.5 GO:0044308 axonal spine(GO:0044308)
0.8 2.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 2.0 GO:0048786 presynaptic active zone(GO:0048786)
0.4 1.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 1.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.9 GO:0030667 secretory granule membrane(GO:0030667)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.5 GO:0051286 cell tip(GO:0051286)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.8 5.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 4.5 GO:0003779 actin binding(GO:0003779)
0.0 2.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.8 2.3 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 1.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.8 GO:0030275 LRR domain binding(GO:0030275)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.1 1.7 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.5 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.2 1.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 1.3 GO:0031402 sodium ion binding(GO:0031402)
0.1 1.2 GO:0050897 cobalt ion binding(GO:0050897)
0.0 1.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 1.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.0 GO:0005158 insulin receptor binding(GO:0005158)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 5.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 2.3 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.4 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 3.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.9 2.6 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 2.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 1.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 0.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.8 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.7 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 0.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.4 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation