Motif ID: Nr4a2

Z-value: 0.588


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57124003_571240710.292.4e-01Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 2.325 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr18_+_86711059 1.595 ENSMUST00000068423.3
 Cbln2
cerebellin 2 precursor protein
chr7_-_100514800 1.377 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr11_+_70657687 1.115 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr8_+_68880491 1.108 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr2_+_4976113 0.952 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr11_+_70657196 0.946 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr9_-_32344237 0.934 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr6_-_124814288 0.819 ENSMUST00000172132.2
 Tpi1
triosephosphate isomerase 1
chrX_+_150589907 0.791 ENSMUST00000080884.4
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr15_-_42676967 0.757 ENSMUST00000022921.5
 Angpt1
angiopoietin 1
chr2_-_129699833 0.717 ENSMUST00000028883.5
 Pdyn
prodynorphin
chr10_+_93589413 0.709 ENSMUST00000181835.1
 4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr13_+_93304066 0.690 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chrX_-_48513518 0.672 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr5_+_111581422 0.637 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr5_-_121527186 0.604 ENSMUST00000152270.1
 Mapkapk5
MAP kinase-activated protein kinase 5
chrX_-_73921917 0.575 ENSMUST00000114389.3
 Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr2_-_73911323 0.572 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chrX_-_73921930 0.528 ENSMUST00000033763.8
 Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 2.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.7 GO:0035082 axoneme assembly(GO:0035082)
0.3 1.6 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.3 1.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 1.0 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.2 0.9 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.3 0.8 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.3 0.8 GO:0006597 spermine biosynthetic process(GO:0006597)
0.3 0.8 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.1 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.7 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.6 GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity(GO:2000277)
0.1 0.6 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 0.5 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.1 0.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 1.7 GO:0031415 NatA complex(GO:0031415)
0.0 1.7 GO:0005930 axoneme(GO:0005930)
0.2 1.1 GO:0042627 chylomicron(GO:0042627)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 0.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 0.8 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 0.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.6 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 0.4 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.3 GO:0032009 early phagosome(GO:0032009)
0.0 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 1.6 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 1.4 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 0.8 GO:0019808 polyamine binding(GO:0019808)
0.1 0.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.8 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.8 GO:0016504 peptidase activator activity(GO:0016504)
0.2 0.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.4 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.3 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.1 0.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 ST_ADRENERGIC Adrenergic Pathway
0.0 0.7 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.1 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.7 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)