Motif ID: Nfix

Z-value: 1.224


Transcription factors associated with Nfix:

Gene SymbolEntrez IDGene Name
Nfix ENSMUSG00000001911.10 Nfix

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfixmm10_v2_chr8_-_84773381_847734270.902.8e-07Click!


Activity profile for motif Nfix.

activity profile for motif Nfix


Sorted Z-values histogram for motif Nfix

Sorted Z-values for motif Nfix



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfix

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 10.498 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr4_+_48045144 5.008 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_-_56969864 4.566 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 4.450 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr13_+_16014457 4.350 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr16_+_42907563 3.784 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr13_+_83504032 3.646 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr5_+_66745835 3.393 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr9_+_89909775 3.392 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr18_-_78123324 3.262 ENSMUST00000160292.1
ENSMUST00000091813.5
 Slc14a1

solute carrier family 14 (urea transporter), member 1

chr7_-_103827922 3.217 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr5_+_66968961 3.182 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr4_-_46991842 3.025 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr3_+_156562141 3.018 ENSMUST00000175773.1
 Negr1
neuronal growth regulator 1
chr18_+_34247685 2.974 ENSMUST00000066133.6
 Apc
adenomatosis polyposis coli
chr13_+_42866247 2.902 ENSMUST00000131942.1
 Phactr1
phosphatase and actin regulator 1
chr7_-_97417730 2.851 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr4_+_102570065 2.631 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr18_-_23038656 2.584 ENSMUST00000081423.6
 Nol4
nucleolar protein 4
chrX_-_143933089 2.558 ENSMUST00000087313.3
 Dcx
doublecortin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 10.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.6 9.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 8.9 GO:0031032 actomyosin structure organization(GO:0031032)
0.4 5.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.6 5.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.7 5.0 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 4.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 4.6 GO:0032060 bleb assembly(GO:0032060)
0.9 4.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
1.2 3.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
1.1 3.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 3.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.2 3.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.1 3.2 GO:0060612 adipose tissue development(GO:0060612)
0.2 3.1 GO:0060134 prepulse inhibition(GO:0060134)
0.7 3.0 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.1 3.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.4 2.9 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.1 2.9 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.5 2.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.2 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 7.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 5.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 5.3 GO:0031430 M band(GO:0031430)
0.0 5.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.9 GO:0043025 neuronal cell body(GO:0043025)
1.4 4.3 GO:0043512 inhibin A complex(GO:0043512)
0.2 3.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.8 3.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 3.1 GO:0030017 sarcomere(GO:0030017)
0.6 3.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.4 3.0 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.7 2.9 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 2.6 GO:0030426 growth cone(GO:0030426)
0.2 2.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 2.1 GO:0043218 compact myelin(GO:0043218)
0.1 1.9 GO:0071565 nBAF complex(GO:0071565)
0.0 1.7 GO:0099738 cell cortex region(GO:0099738)
0.1 1.6 GO:0031045 dense core granule(GO:0031045)
0.0 1.5 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 10.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 6.8 GO:0003779 actin binding(GO:0003779)
0.2 6.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 5.3 GO:0030507 spectrin binding(GO:0030507)
0.1 5.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 4.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.7 4.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 3.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 3.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 3.3 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.7 3.3 GO:0015265 urea channel activity(GO:0015265)
0.8 3.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.5 3.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 3.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 2.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 2.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 4.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 3.7 PID_ALK1_PATHWAY ALK1 signaling events
0.2 3.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.0 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 2.9 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 2.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.6 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.7 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 1.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.7 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 1.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 10.5 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 5.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 4.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
1.1 4.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 4.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 3.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 3.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 3.0 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 2.9 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 2.6 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 2.2 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 1.9 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.7 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.2 1.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.5 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters