Motif ID: Nr2f1_Nr4a1

Z-value: 1.565

Transcription factors associated with Nr2f1_Nr4a1:

Gene SymbolEntrez IDGene Name
Nr2f1 ENSMUSG00000069171.7 Nr2f1
Nr4a1 ENSMUSG00000023034.6 Nr4a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a1mm10_v2_chr15_+_101266839_101266859-0.864.0e-06Click!
Nr2f1mm10_v2_chr13_-_78199757_781998550.493.9e-02Click!


Activity profile for motif Nr2f1_Nr4a1.

activity profile for motif Nr2f1_Nr4a1


Sorted Z-values histogram for motif Nr2f1_Nr4a1

Sorted Z-values for motif Nr2f1_Nr4a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f1_Nr4a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_119578981 8.638 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr17_+_43952999 6.421 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr1_+_12718496 4.540 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr1_+_166254095 4.425 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr12_-_110978981 4.300 ENSMUST00000135131.1
ENSMUST00000043459.6
ENSMUST00000128353.1
 Ankrd9


ankyrin repeat domain 9


chr3_-_138131356 4.195 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr18_+_57142782 3.902 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr13_+_21722057 3.818 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr3_+_146500071 3.713 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr10_+_128194446 3.605 ENSMUST00000044776.6
 Gls2
glutaminase 2 (liver, mitochondrial)
chr12_-_111672290 3.421 ENSMUST00000001304.7
 Ckb
creatine kinase, brain
chr6_-_119544282 3.202 ENSMUST00000119369.1
ENSMUST00000178696.1
 Wnt5b

wingless-related MMTV integration site 5B

chr6_-_76497631 3.201 ENSMUST00000097218.5
 Gm9008
predicted pseudogene 9008
chr4_-_41697040 3.156 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr11_-_114795888 2.977 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17
chr5_-_116422858 2.946 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr5_+_111581422 2.875 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr3_+_32736990 2.864 ENSMUST00000127477.1
ENSMUST00000121778.1
ENSMUST00000154257.1
 Ndufb5


NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5


chr2_-_73911323 2.796 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr2_-_129699833 2.786 ENSMUST00000028883.5
 Pdyn
prodynorphin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 317 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
2.9 8.6 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
1.6 6.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 6.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 5.7 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.9 5.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.8 4.7 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.9 4.6 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.8 4.6 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 4.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.4 4.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 4.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 4.0 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 3.8 GO:0006334 nucleosome assembly(GO:0006334)
0.6 3.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 3.7 GO:0014003 oligodendrocyte development(GO:0014003)
0.2 3.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.6 3.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 3.3 GO:0032543 mitochondrial translation(GO:0032543)
0.8 3.2 GO:0003360 brainstem development(GO:0003360)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 13.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 9.5 GO:0031012 extracellular matrix(GO:0031012)
0.1 7.7 GO:0005759 mitochondrial matrix(GO:0005759)
0.5 7.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.6 6.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 6.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.9 GO:0016607 nuclear speck(GO:0016607)
1.8 5.4 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 5.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.3 5.2 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.3 4.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 4.8 GO:0000118 histone deacetylase complex(GO:0000118)
1.1 4.6 GO:1990584 cardiac Troponin complex(GO:1990584)
0.3 4.5 GO:0031528 microvillus membrane(GO:0031528)
0.1 4.3 GO:0016605 PML body(GO:0016605)
0.0 4.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.0 4.2 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.5 4.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 4.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 4.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 227 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 GO:0005109 frizzled binding(GO:0005109)
1.1 7.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 7.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.3 6.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
1.1 6.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 5.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.5 GO:0051082 unfolded protein binding(GO:0051082)
1.5 4.6 GO:0030172 troponin C binding(GO:0030172)
0.3 4.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.4 4.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 4.1 GO:0009055 electron carrier activity(GO:0009055)
0.4 4.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 3.9 GO:0001849 complement component C1q binding(GO:0001849)
0.2 3.8 GO:0070410 co-SMAD binding(GO:0070410)
0.2 3.8 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 3.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 3.7 GO:0001047 core promoter binding(GO:0001047)
0.0 3.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 3.5 GO:0043532 angiostatin binding(GO:0043532)
0.4 3.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 7.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 6.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 6.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 6.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.9 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 3.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 3.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.2 PID_PLK1_PATHWAY PLK1 signaling events
0.0 3.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 2.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.5 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 2.3 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 1.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.4 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 29.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 9.0 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 8.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 8.2 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.2 6.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 5.6 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 5.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.3 5.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 5.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 4.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.4 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.3 4.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.5 3.9 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2 3.9 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.1 3.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.8 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.3 3.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 2.7 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation