Motif ID: Mybl2

Z-value: 1.606


Transcription factors associated with Mybl2:

Gene SymbolEntrez IDGene Name
Mybl2 ENSMUSG00000017861.5 Mybl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl2mm10_v2_chr2_+_163054682_1630546930.832.1e-05Click!


Activity profile for motif Mybl2.

activity profile for motif Mybl2


Sorted Z-values histogram for motif Mybl2

Sorted Z-values for motif Mybl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_90002881 3.248 ENSMUST00000020864.8
 Pctp
phosphatidylcholine transfer protein
chr1_-_169531343 3.167 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr9_-_79977782 2.893 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr1_-_169531447 2.657 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr19_-_41802028 2.619 ENSMUST00000026150.8
ENSMUST00000177495.1
ENSMUST00000163265.1
 Arhgap19


Rho GTPase activating protein 19


chr2_+_13573927 2.607 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr11_-_106999369 2.512 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr13_-_81710937 2.417 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr13_-_23551648 2.394 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr8_+_83715504 2.322 ENSMUST00000109810.1
 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr10_+_84838143 2.300 ENSMUST00000095388.4
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr4_-_124936852 2.126 ENSMUST00000030690.5
ENSMUST00000084296.3
 Cdca8

cell division cycle associated 8

chr11_-_106999482 2.046 ENSMUST00000018506.6
 Kpna2
karyopherin (importin) alpha 2
chr12_+_51593315 2.024 ENSMUST00000164782.2
ENSMUST00000085412.5
 Coch

coagulation factor C homolog (Limulus polyphemus)

chr19_+_53142756 1.970 ENSMUST00000050096.7
 Add3
adducin 3 (gamma)
chr4_-_116627921 1.912 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr7_-_4812351 1.910 ENSMUST00000079496.7
 Ube2s
ubiquitin-conjugating enzyme E2S
chr9_+_92250039 1.868 ENSMUST00000093801.3
 Plscr1
phospholipid scramblase 1
chr15_+_26309039 1.815 ENSMUST00000140840.1
ENSMUST00000152841.1
 March11

membrane-associated ring finger (C3HC4) 11

chr1_-_44101661 1.795 ENSMUST00000152239.1
 Tex30
testis expressed 30

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.1 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.2 3.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 3.6 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 3.2 GO:0015914 phospholipid transport(GO:0015914)
0.2 3.1 GO:0051451 myoblast migration(GO:0051451)
0.2 2.9 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.5 2.7 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 2.7 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.5 2.6 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1 2.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 2.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.5 2.3 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.5 2.3 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 2.3 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.2 2.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 2.0 GO:0007099 centriole replication(GO:0007099)
0.0 2.0 GO:0042493 response to drug(GO:0042493)
0.6 1.9 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.6 1.9 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.2 1.9 GO:0071557 histone H3-K27 demethylation(GO:0071557)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.3 GO:0031262 Ndc80 complex(GO:0031262)
0.1 4.4 GO:0005643 nuclear pore(GO:0005643)
0.0 4.1 GO:0005681 spliceosomal complex(GO:0005681)
0.1 3.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 3.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 3.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.4 3.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 3.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.7 GO:0030992 intraciliary transport particle B(GO:0030992)
0.7 2.6 GO:0045098 type III intermediate filament(GO:0045098)
0.0 2.6 GO:0005871 kinesin complex(GO:0005871)
0.1 2.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.4 2.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.9 GO:0072686 mitotic spindle(GO:0072686)
0.6 1.8 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 1.8 GO:0061574 ASAP complex(GO:0061574)
0.0 1.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0042393 histone binding(GO:0042393)
0.1 4.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 3.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 3.6 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.3 3.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.2 2.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 2.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.7 2.6 GO:1990254 keratin filament binding(GO:1990254)
0.0 2.6 GO:0003777 microtubule motor activity(GO:0003777)
0.6 2.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 2.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.0 GO:0005080 protein kinase C binding(GO:0005080)
0.3 1.9 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 1.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.9 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 1.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 1.8 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.6 1.7 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 7.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 4.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 3.4 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 1.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.4 PID_ATM_PATHWAY ATM pathway
0.0 1.2 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.1 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 7.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 5.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 3.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.3 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.1 2.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.7 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.5 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.4 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 1.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.3 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism