Motif ID: Irx6_Irx2_Irx3

Z-value: 1.105

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx6mm10_v2_chr8_+_92674826_926748260.312.1e-01Click!
Irx3mm10_v2_chr8_-_91801948_918020670.213.9e-01Click!
Irx2mm10_v2_chr13_+_72628802_726288250.087.4e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 6.579 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr10_+_26229707 3.564 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr13_+_23544052 2.481 ENSMUST00000075558.2
 Hist1h3f
histone cluster 1, H3f
chr11_-_76399107 2.479 ENSMUST00000021204.3
 Nxn
nucleoredoxin
chr10_-_29699379 2.371 ENSMUST00000092620.4
 Gm10275
predicted pseudogene 10275
chr12_-_74316394 2.271 ENSMUST00000110441.1
 Gm11042
predicted gene 11042
chr17_+_17316078 2.261 ENSMUST00000105311.3
 Gm6712
predicted gene 6712
chr7_+_140763739 2.137 ENSMUST00000026552.7
 Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr10_-_39122277 1.949 ENSMUST00000136546.1
 Fam229b
family with sequence similarity 229, member B
chr18_+_36664060 1.925 ENSMUST00000036765.7
 Eif4ebp3
eukaryotic translation initiation factor 4E binding protein 3
chr8_-_84065137 1.586 ENSMUST00000098592.2
 Gm10643
predicted gene 10643
chr13_+_49504774 1.583 ENSMUST00000051504.7
 Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_-_98667264 1.573 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr15_-_35938009 1.572 ENSMUST00000156915.1
 Cox6c
cytochrome c oxidase subunit VIc
chr15_-_35938186 1.542 ENSMUST00000014457.8
 Cox6c
cytochrome c oxidase subunit VIc
chr17_+_46496753 1.528 ENSMUST00000046497.6
 Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr2_-_67433181 1.445 ENSMUST00000180773.1
 Gm26727
predicted gene, 26727
chr3_-_57651667 1.403 ENSMUST00000160959.1
 Commd2
COMM domain containing 2
chr17_-_57839233 1.341 ENSMUST00000095218.3
 Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr12_+_69963452 1.326 ENSMUST00000110560.1
 Gm3086
predicted gene 3086

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 5.4 GO:0006334 nucleosome assembly(GO:0006334)
0.2 2.3 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 2.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 2.1 GO:0017144 drug metabolic process(GO:0017144)
0.1 2.0 GO:0045047 protein targeting to ER(GO:0045047)
0.1 1.9 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.6 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 1.5 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.1 1.3 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 1.3 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 1.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 1.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.3 1.0 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
0.2 0.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.9 GO:0030035 microspike assembly(GO:0030035)
0.0 0.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.8 GO:0009235 cobalamin metabolic process(GO:0009235)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 6.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 4.4 GO:0000786 nucleosome(GO:0000786)
0.0 2.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 2.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.6 GO:0005687 U4 snRNP(GO:0005687)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4 1.3 GO:0000801 central element(GO:0000801)
0.1 1.3 GO:0061574 ASAP complex(GO:0061574)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.0 GO:0005787 signal peptidase complex(GO:0005787)
0.2 0.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.2 0.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.7 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 3.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 2.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.3 2.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 1.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.5 1.6 GO:0070052 collagen V binding(GO:0070052)
0.1 1.6 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.5 1.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 1.1 GO:0043199 sulfate binding(GO:0043199)
0.1 1.1 GO:0008097 5S rRNA binding(GO:0008097)
0.3 1.0 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.0 1.0 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.2 0.9 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 0.9 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.5 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.4 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.3 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 4.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 3.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 3.4 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 2.1 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 1.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.9 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 0.8 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 0.7 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.7 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.5 REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM Genes involved in Bile acid and bile salt metabolism
0.1 0.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling