Motif ID: Zfhx3

Z-value: 0.932


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.155.4e-01Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 96 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 4.778 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr10_-_110000219 3.823 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr13_-_110280103 3.764 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chrX_-_143933089 2.741 ENSMUST00000087313.3
 Dcx
doublecortin
chr9_+_86485407 2.213 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr2_+_82053222 2.101 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr5_+_107497718 2.060 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chrX_-_143933204 1.924 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr4_+_13743424 1.911 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_28263205 1.843 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr1_+_179961110 1.764 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr17_+_35076902 1.658 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr5_+_107497762 1.553 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr13_+_83732438 1.352 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr16_-_74411776 1.320 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr9_+_113812547 1.251 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr2_-_63184253 1.245 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr5_-_107875035 1.230 ENSMUST00000138111.1
ENSMUST00000112642.1
 Evi5

ecotropic viral integration site 5

chr10_-_56228636 1.209 ENSMUST00000099739.3
 Tbc1d32
TBC1 domain family, member 32
chr2_+_120977017 1.189 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 4.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 3.6 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 2.7 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 2.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 1.9 GO:0051291 protein heterooligomerization(GO:0051291)
0.4 1.8 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 1.7 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.0 1.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.4 1.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4 1.2 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.2 1.2 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 1.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.3 0.8 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.0 0.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.7 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0030426 growth cone(GO:0030426)
0.0 4.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.7 GO:0042641 actomyosin(GO:0042641)
0.0 2.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.8 GO:0055037 recycling endosome(GO:0055037)
0.3 1.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.3 GO:0030673 axolemma(GO:0030673)
0.0 1.2 GO:0001741 XY body(GO:0001741)
0.1 1.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.5 GO:0001739 sex chromatin(GO:0001739)
0.1 0.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)
0.2 3.8 GO:0031489 myosin V binding(GO:0031489)
0.0 2.6 GO:0000287 magnesium ion binding(GO:0000287)
0.1 1.9 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.6 1.7 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.1 1.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.3 GO:0002162 dystroglycan binding(GO:0002162)
0.2 1.2 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 0.9 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.8 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.4 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 0.4 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 0.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.7 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 1.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 1.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 0.4 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 0.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.4 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.4 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis