Motif ID: Pax2

Z-value: 0.755


Transcription factors associated with Pax2:

Gene SymbolEntrez IDGene Name
Pax2 ENSMUSG00000004231.9 Pax2



Activity profile for motif Pax2.

activity profile for motif Pax2


Sorted Z-values histogram for motif Pax2

Sorted Z-values for motif Pax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 1.933 ENSMUST00000165033.1
 Egr1
early growth response 1
chr4_+_148039097 1.795 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr2_+_30286406 1.572 ENSMUST00000138666.1
ENSMUST00000113634.2
 Nup188

nucleoporin 188

chr17_+_26715644 1.450 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr12_-_102878406 1.413 ENSMUST00000045652.6
 Btbd7
BTB (POZ) domain containing 7
chr4_+_148039035 1.380 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr16_-_45158183 1.357 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr13_+_13590402 1.243 ENSMUST00000110559.1
 Lyst
lysosomal trafficking regulator
chr16_-_45158624 1.185 ENSMUST00000180636.1
 Slc35a5
solute carrier family 35, member A5
chr9_+_46012822 1.147 ENSMUST00000120463.2
ENSMUST00000120247.1
 Sik3

SIK family kinase 3

chr16_+_94370786 1.142 ENSMUST00000147046.1
ENSMUST00000149885.1
ENSMUST00000127667.1
ENSMUST00000119131.1
ENSMUST00000145883.1
 Ttc3




tetratricopeptide repeat domain 3




chr7_+_125707945 1.096 ENSMUST00000148701.1
 D430042O09Rik
RIKEN cDNA D430042O09 gene
chr2_-_169405435 1.049 ENSMUST00000131509.1
 4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr2_+_119897212 1.043 ENSMUST00000046717.6
ENSMUST00000110774.1
ENSMUST00000110773.2
ENSMUST00000079934.5
ENSMUST00000156510.1
 Mga




MAX gene associated




chr16_-_44139003 1.033 ENSMUST00000124102.1
 Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr19_-_57008187 1.031 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
 Afap1l2



actin filament associated protein 1-like 2



chr16_-_45158566 0.974 ENSMUST00000181177.1
 Slc35a5
solute carrier family 35, member A5
chr15_-_77956658 0.926 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2

chr9_-_42124276 0.924 ENSMUST00000060989.8
 Sorl1
sortilin-related receptor, LDLR class A repeats-containing
chr16_-_45158453 0.915 ENSMUST00000181750.1
 Slc35a5
solute carrier family 35, member A5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 GO:0008643 carbohydrate transport(GO:0008643)
0.8 3.2 GO:0070829 heterochromatin maintenance(GO:0070829)
0.4 2.0 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 2.0 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 2.0 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.6 1.9 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 1.6 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.5 1.5 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.3 1.5 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0 1.5 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.1 1.4 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 1.4 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 1.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.4 1.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.2 1.2 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.0 1.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.0 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 1.0 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.3 0.9 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.3 0.9 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 GO:0000139 Golgi membrane(GO:0000139)
0.4 2.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 1.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.2 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.0 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.9 GO:0010369 chromocenter(GO:0010369)
0.3 0.8 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 0.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.7 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.6 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.1 GO:0005351 sugar:proton symporter activity(GO:0005351)
1.1 3.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 2.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.5 1.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 1.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.9 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 0.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.9 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.9 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.9 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.7 PID_BARD1_PATHWAY BARD1 signaling events
0.1 0.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.3 PID_FAS_PATHWAY FAS (CD95) signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.3 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.4 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.3 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.9 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 0.8 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 0.7 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.4 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.0 0.4 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE