Motif ID: Rxrb

Z-value: 0.716


Transcription factors associated with Rxrb:

Gene SymbolEntrez IDGene Name
Rxrb ENSMUSG00000039656.10 Rxrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rxrbmm10_v2_chr17_+_34032071_34032196-0.361.5e-01Click!


Activity profile for motif Rxrb.

activity profile for motif Rxrb


Sorted Z-values histogram for motif Rxrb

Sorted Z-values for motif Rxrb



Network of associatons between targets according to the STRING database.



First level regulatory network of Rxrb

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 3.429 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_-_116422858 2.300 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr14_-_118052235 2.286 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr10_+_93641041 1.796 ENSMUST00000020204.4
 Ntn4
netrin 4
chr1_+_74791516 1.502 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr4_-_117178726 1.244 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr11_+_40733936 1.231 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chr1_+_146420434 1.208 ENSMUST00000163646.1
 Gm5263
predicted gene 5263
chr11_+_40733639 1.187 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr1_+_84839833 1.180 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr4_+_44300876 1.099 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr18_+_57142782 1.013 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr1_+_6487231 0.940 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr17_-_35704000 0.881 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr14_+_54476100 0.876 ENSMUST00000164766.1
ENSMUST00000164697.1
 Rem2

rad and gem related GTP binding protein 2

chr5_+_110839973 0.858 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr1_-_170306332 0.857 ENSMUST00000179801.1
 Gm7694
predicted gene 7694
chr8_+_72135247 0.851 ENSMUST00000003575.9
 Tpm4
tropomyosin 4
chr14_-_118706180 0.843 ENSMUST00000036554.6
ENSMUST00000166646.1
 Abcc4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr5_+_47984571 0.811 ENSMUST00000174313.1
 Slit2
slit homolog 2 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 2.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.4 1.8 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 1.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 1.4 GO:0051028 mRNA transport(GO:0051028)
0.2 1.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 1.2 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.0 1.1 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.2 1.0 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.2 0.9 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.1 0.9 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.9 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.1 0.9 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 0.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 0.8 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.8 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 0.8 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.2 0.7 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.7 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.0 0.7 GO:0000338 protein deneddylation(GO:0000338)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0000776 kinetochore(GO:0000776)
0.1 2.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.1 1.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.2 GO:0016234 inclusion body(GO:0016234)
0.0 1.0 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 0.8 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.5 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.4 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.4 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.6 GO:0043237 laminin-1 binding(GO:0043237)
0.2 2.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 2.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.7 GO:0051087 chaperone binding(GO:0051087)
0.0 1.5 GO:0005109 frizzled binding(GO:0005109)
0.1 1.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.0 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.0 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 0.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.5 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.4 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.2 PID_ATM_PATHWAY ATM pathway
0.0 0.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.1 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.2 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 0.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.8 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 0.6 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 0.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.1 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators