Motif ID: Rxrb
Z-value: 0.716
Transcription factors associated with Rxrb:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rxrb | ENSMUSG00000039656.10 | Rxrb |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rxrb | mm10_v2_chr17_+_34032071_34032196 | -0.36 | 1.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.4 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.4 | 2.3 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.4 | 1.8 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.3 | 0.8 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.2 | 1.2 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.2 | 0.7 | GO:0019046 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 0.2 | 0.9 | GO:1903463 | regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.2 | 1.0 | GO:0043654 | skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654) |
| 0.1 | 0.4 | GO:1900060 | negative regulation of ceramide biosynthetic process(GO:1900060) |
| 0.1 | 1.2 | GO:0061084 | negative regulation of protein refolding(GO:0061084) |
| 0.1 | 1.5 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.1 | 0.9 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
| 0.1 | 0.4 | GO:0071707 | immunoglobulin heavy chain V-D-J recombination(GO:0071707) |
| 0.1 | 0.7 | GO:0086028 | bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) |
| 0.1 | 0.5 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905024) |
| 0.1 | 0.6 | GO:1904587 | response to glycoprotein(GO:1904587) |
| 0.1 | 0.9 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.1 | 0.3 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
| 0.1 | 0.8 | GO:0006855 | drug transmembrane transport(GO:0006855) |
| 0.1 | 0.9 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.1 | 0.9 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 0.5 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.1 | 0.4 | GO:0021539 | subthalamus development(GO:0021539) |
| 0.1 | 0.8 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 0.4 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.1 | 0.3 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.1 | 0.4 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
| 0.0 | 0.2 | GO:0051890 | regulation of cardioblast differentiation(GO:0051890) |
| 0.0 | 0.1 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.0 | 0.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 0.3 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.0 | 0.3 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.3 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.5 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.0 | 0.5 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.0 | 0.4 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.0 | 0.1 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 0.0 | 0.6 | GO:0030903 | notochord development(GO:0030903) |
| 0.0 | 0.6 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.0 | 0.5 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) negative regulation of collateral sprouting(GO:0048671) |
| 0.0 | 1.1 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 0.0 | 0.3 | GO:0002385 | mucosal immune response(GO:0002385) |
| 0.0 | 0.4 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.1 | GO:0045919 | complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919) |
| 0.0 | 0.1 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.0 | 0.4 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.1 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.0 | 0.1 | GO:1990000 | amyloid fibril formation(GO:1990000) |
| 0.0 | 0.3 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.0 | 0.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.1 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.0 | 1.4 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.0 | GO:0015793 | glycerol transport(GO:0015793) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.1 | 1.4 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 0.4 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.1 | 2.3 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.9 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 0.5 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.6 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.3 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.0 | 1.0 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.1 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.0 | 0.4 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.0 | 0.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.5 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 1.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 1.8 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 2.4 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 0.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.0 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.4 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.2 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.3 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.2 | 2.3 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.1 | 1.0 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 1.0 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.1 | 0.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 1.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 0.4 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 0.6 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.4 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.3 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.0 | 1.5 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.6 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.4 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.1 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 0.0 | 0.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.1 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.0 | 0.3 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.1 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.0 | 1.7 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 1.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 2.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 3.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.4 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.7 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.6 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.2 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.1 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.0 | GO:0015254 | glycerol channel activity(GO:0015254) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.7 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 1.2 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.8 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 0.6 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 2.5 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.1 | PID_ALK2_PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.1 | 0.8 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.1 | 0.9 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 0.6 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 1.2 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 2.6 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 1.4 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.0 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.9 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.3 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.5 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.1 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.5 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.1 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
