Motif ID: Figla

Z-value: 0.674


Transcription factors associated with Figla:

Gene SymbolEntrez IDGene Name
Figla ENSMUSG00000030001.3 Figla



Activity profile for motif Figla.

activity profile for motif Figla


Sorted Z-values histogram for motif Figla

Sorted Z-values for motif Figla



Network of associatons between targets according to the STRING database.



First level regulatory network of Figla

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_99864476 2.701 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr7_+_19094594 1.682 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr6_+_29694204 1.442 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr7_-_30973464 1.329 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr14_-_20181773 1.319 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr11_+_117809653 1.250 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
 Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr10_+_26229707 1.200 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr2_+_164769892 1.134 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr1_+_74791516 1.125 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr12_+_109459843 1.081 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr2_+_19909769 1.046 ENSMUST00000114610.1
 Etl4
enhancer trap locus 4
chr6_+_54326955 1.034 ENSMUST00000059138.4
 Prr15
proline rich 15
chr7_-_144939823 1.007 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr11_+_115824029 0.985 ENSMUST00000103032.4
ENSMUST00000133250.1
ENSMUST00000177736.1
 Llgl2


lethal giant larvae homolog 2 (Drosophila)


chr6_-_3494587 0.954 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr2_+_168081004 0.928 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr9_+_91368811 0.927 ENSMUST00000173054.1
 Zic4
zinc finger protein of the cerebellum 4
chr15_-_78773452 0.919 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr12_-_40038025 0.868 ENSMUST00000101472.3
 Arl4a
ADP-ribosylation factor-like 4A
chr1_+_92831614 0.858 ENSMUST00000045970.6
 Gpc1
glypican 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 1.9 GO:0048733 sebaceous gland development(GO:0048733)
0.1 1.7 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.4 1.5 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.0 1.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.4 1.3 GO:0036292 DNA rewinding(GO:0036292)
0.4 1.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 1.1 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.3 1.0 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 1.0 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.3 0.9 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.2 0.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.9 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.9 GO:0007043 cell-cell junction assembly(GO:0007043)
0.2 0.8 GO:0035063 nuclear speck organization(GO:0035063)
0.2 0.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.8 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.8 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.8 GO:0048747 muscle fiber development(GO:0048747)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.5 GO:0072687 meiotic spindle(GO:0072687)
0.1 1.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 1.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 1.3 GO:0042627 chylomicron(GO:0042627)
0.0 1.3 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.8 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.7 GO:1990423 RZZ complex(GO:1990423)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.2 0.6 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 0.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 0.6 GO:0033269 internode region of axon(GO:0033269)
0.0 0.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.6 GO:0034451 centriolar satellite(GO:0034451)
0.2 0.5 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 1.3 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.1 GO:0005109 frizzled binding(GO:0005109)
0.3 0.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 0.9 GO:0070052 collagen V binding(GO:0070052)
0.0 0.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.8 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.8 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.1 0.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.7 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.7 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 0.7 GO:0020037 heme binding(GO:0020037)
0.0 0.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 0.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.6 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.1 1.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.6 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 0.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation