Motif ID: Nfatc1

Z-value: 7.300


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80713062_80713080-0.361.4e-01Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 121.013 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3004457 119.835 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3027439 118.965 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3013140 107.558 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3037111 104.463 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3023547 103.767 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3036877 97.709 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3025417 96.786 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3034599 95.347 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3005125 91.130 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3017408 85.414 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr14_-_19418930 78.662 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3015654 75.570 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3018753 72.436 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_-_98667264 71.205 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr2_+_98662227 58.931 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr3_+_94377432 15.258 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr3_+_94377505 11.925 ENSMUST00000098877.2
 Rorc
RAR-related orphan receptor gamma
chr4_-_97778042 10.084 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr7_-_49636847 9.360 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 531.3 GO:0008150 biological_process(GO:0008150)
3.4 27.2 GO:0072615 interleukin-17 secretion(GO:0072615)
2.2 13.0 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.2 9.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 9.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.6 7.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 7.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
1.1 6.8 GO:0032439 endosome localization(GO:0032439)
1.3 6.5 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
2.1 6.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.9 6.2 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
2.0 6.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.7 5.5 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
1.8 5.3 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
1.7 5.2 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
1.6 4.8 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
1.6 4.7 GO:0016554 cytidine to uridine editing(GO:0016554)
1.6 4.7 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.6 4.4 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.3 4.2 GO:0035881 amacrine cell differentiation(GO:0035881)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 701.2 GO:0005575 cellular_component(GO:0005575)
0.0 8.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.1 6.8 GO:0045179 apical cortex(GO:0045179)
0.0 5.8 GO:0005884 actin filament(GO:0005884)
0.0 5.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 5.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 5.4 GO:0005581 collagen trimer(GO:0005581)
0.4 5.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
1.6 4.7 GO:0071914 prominosome(GO:0071914)
1.1 4.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 4.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.9 3.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.5 3.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 3.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 3.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 3.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 3.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 2.9 GO:0016580 Sin3 complex(GO:0016580)
0.2 2.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 2.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 624.2 GO:0003674 molecular_function(GO:0003674)
6.8 27.2 GO:0008142 oxysterol binding(GO:0008142)
0.3 13.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.3 10.8 GO:0042805 actinin binding(GO:0042805)
1.3 6.5 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 6.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 6.4 GO:0030246 carbohydrate binding(GO:0030246)
2.0 6.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.5 5.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 5.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.1 5.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.3 5.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.6 5.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.2 4.7 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 4.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.9 4.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 4.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.8 3.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.9 3.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 3.6 GO:0030332 cyclin binding(GO:0030332)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 10.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.3 9.5 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 6.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 3.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.2 3.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 3.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 3.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.4 2.6 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.2 2.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 2.4 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 1.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID_P73PATHWAY p73 transcription factor network
0.0 1.4 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 35.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 6.5 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 6.5 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.2 6.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.9 5.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 5.4 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.2 5.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 4.1 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.4 3.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.2 3.5 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 3.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 3.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 3.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.3 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 3.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.1 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.2 2.5 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 2.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 2.1 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends