Motif ID: Nfatc1
Z-value: 7.300
Transcription factors associated with Nfatc1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nfatc1 | ENSMUSG00000033016.9 | Nfatc1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfatc1 | mm10_v2_chr18_-_80713062_80713080 | -0.36 | 1.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 27.2 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
| 2.2 | 13.0 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 2.1 | 6.4 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
| 2.0 | 6.1 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 1.8 | 5.3 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 1.7 | 5.2 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 1.6 | 4.8 | GO:0035622 | intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034) |
| 1.6 | 4.7 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 1.6 | 4.7 | GO:0072139 | glomerular parietal epithelial cell differentiation(GO:0072139) |
| 1.3 | 6.5 | GO:1901526 | negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925) |
| 1.3 | 2.5 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 1.2 | 3.6 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) |
| 1.1 | 6.8 | GO:0032439 | endosome localization(GO:0032439) |
| 1.0 | 2.1 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.9 | 2.7 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.9 | 1.8 | GO:0001787 | natural killer cell proliferation(GO:0001787) |
| 0.9 | 6.2 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.9 | 2.6 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
| 0.8 | 2.3 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.8 | 3.0 | GO:1903416 | negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of calcidiol 1-monooxygenase activity(GO:0060558) response to glycoside(GO:1903416) |
| 0.7 | 5.5 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474) |
| 0.7 | 2.7 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.7 | 2.0 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.6 | 4.4 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.6 | 7.6 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
| 0.6 | 3.1 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.6 | 3.0 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 0.6 | 3.5 | GO:1904587 | response to glycoprotein(GO:1904587) |
| 0.5 | 9.4 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.5 | 3.5 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
| 0.5 | 1.5 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 0.5 | 2.0 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.5 | 2.9 | GO:0098734 | protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) macromolecule depalmitoylation(GO:0098734) |
| 0.5 | 3.3 | GO:0097152 | mesenchymal cell apoptotic process(GO:0097152) |
| 0.5 | 2.7 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.4 | 1.8 | GO:0051794 | regulation of catagen(GO:0051794) |
| 0.4 | 7.3 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.3 | 3.3 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.3 | 4.2 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.3 | 3.4 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.3 | 0.9 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 0.3 | 1.2 | GO:0090282 | positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282) |
| 0.3 | 1.1 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
| 0.3 | 0.9 | GO:0090135 | actin filament branching(GO:0090135) negative regulation of phospholipase C activity(GO:1900275) |
| 0.3 | 0.8 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
| 0.3 | 1.1 | GO:0035989 | tendon development(GO:0035989) |
| 0.3 | 2.5 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.3 | 0.8 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.3 | 2.5 | GO:0043586 | tongue development(GO:0043586) |
| 0.2 | 1.3 | GO:0071883 | activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.2 | 9.9 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 2.1 | GO:0072189 | ureter development(GO:0072189) |
| 0.2 | 1.0 | GO:0007320 | insemination(GO:0007320) |
| 0.2 | 1.2 | GO:0061009 | common bile duct development(GO:0061009) |
| 0.2 | 0.6 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) negative regulation of Fas signaling pathway(GO:1902045) |
| 0.2 | 1.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.2 | 3.3 | GO:0055070 | copper ion homeostasis(GO:0055070) |
| 0.2 | 1.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.2 | 3.5 | GO:0021670 | lateral ventricle development(GO:0021670) negative regulation of histone H3-K9 methylation(GO:0051573) |
| 0.2 | 0.7 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.2 | 0.8 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.2 | 2.5 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.2 | 2.4 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.2 | 1.4 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.2 | 1.3 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.2 | 1.6 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 0.1 | 2.3 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
| 0.1 | 0.8 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 4.2 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 0.6 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 2.1 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.1 | 1.9 | GO:0030575 | nuclear body organization(GO:0030575) |
| 0.1 | 1.4 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 2.6 | GO:0060441 | epithelial tube branching involved in lung morphogenesis(GO:0060441) |
| 0.1 | 1.9 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
| 0.1 | 2.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
| 0.1 | 0.7 | GO:0060019 | radial glial cell differentiation(GO:0060019) |
| 0.1 | 1.5 | GO:0032506 | cytokinetic process(GO:0032506) |
| 0.1 | 2.0 | GO:0010883 | regulation of lipid storage(GO:0010883) |
| 0.1 | 3.0 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.1 | 1.3 | GO:0048671 | negative regulation of collateral sprouting(GO:0048671) |
| 0.1 | 0.8 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
| 0.1 | 0.6 | GO:0002536 | respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.1 | 0.5 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.1 | 0.4 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.1 | 1.9 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
| 0.1 | 2.7 | GO:0042491 | auditory receptor cell differentiation(GO:0042491) |
| 0.1 | 1.6 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.1 | 0.8 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.0 | 0.8 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.4 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.0 | 0.3 | GO:0043137 | DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137) |
| 0.0 | 0.2 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 1.3 | GO:0032801 | receptor catabolic process(GO:0032801) |
| 0.0 | 0.5 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.0 | 1.0 | GO:0043153 | photoperiodism(GO:0009648) entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.0 | 0.5 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 0.1 | GO:1901860 | positive regulation of mitochondrial DNA metabolic process(GO:1901860) |
| 0.0 | 1.3 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.0 | 0.4 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.0 | 1.2 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.0 | 1.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 1.2 | GO:0006801 | superoxide metabolic process(GO:0006801) |
| 0.0 | 1.1 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 531.3 | GO:0008150 | biological_process(GO:0008150) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:0071914 | prominosome(GO:0071914) |
| 1.1 | 6.8 | GO:0045179 | apical cortex(GO:0045179) |
| 1.1 | 4.4 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.9 | 3.6 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) |
| 0.8 | 2.3 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.7 | 2.0 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.5 | 1.6 | GO:0000811 | GINS complex(GO:0000811) |
| 0.5 | 3.6 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.4 | 3.0 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.4 | 5.2 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.3 | 2.0 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.2 | 3.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.2 | 1.3 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.2 | 5.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.2 | 3.0 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.2 | 2.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 1.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.2 | 2.3 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 2.9 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 1.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 4.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 2.1 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.8 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.1 | 0.6 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 1.5 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 0.5 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 1.1 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 3.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 0.8 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.1 | 5.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 0.6 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 1.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 1.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 0.4 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 2.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 2.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.5 | GO:0002177 | manchette(GO:0002177) |
| 0.1 | 0.4 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 2.5 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 1.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 5.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 8.4 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.3 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 5.8 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 701.2 | GO:0005575 | cellular_component(GO:0005575) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 27.2 | GO:0008142 | oxysterol binding(GO:0008142) |
| 2.0 | 6.1 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 1.3 | 6.5 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 1.2 | 4.7 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 1.1 | 5.5 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.9 | 3.6 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.9 | 4.4 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.8 | 3.1 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.8 | 3.8 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.7 | 2.9 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.7 | 2.0 | GO:0035651 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
| 0.6 | 5.2 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.5 | 5.7 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.5 | 3.0 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.4 | 2.6 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.3 | 10.8 | GO:0042805 | actinin binding(GO:0042805) |
| 0.3 | 1.0 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.3 | 13.0 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.3 | 1.3 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.3 | 2.3 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.3 | 3.5 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.3 | 2.9 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.3 | 1.1 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.3 | 0.8 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
| 0.3 | 5.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 2.0 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.2 | 4.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.2 | 1.5 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.2 | 3.4 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.2 | 1.0 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 3.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.2 | 0.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 0.9 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 1.9 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.4 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) |
| 0.1 | 4.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 1.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.5 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.1 | 1.6 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.1 | 6.5 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 1.4 | GO:0048038 | quinone binding(GO:0048038) |
| 0.1 | 1.6 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.1 | 2.5 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.1 | 1.5 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 0.6 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.1 | 2.3 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.1 | 0.4 | GO:0004342 | glucosamine-6-phosphate deaminase activity(GO:0004342) |
| 0.1 | 0.9 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.1 | 3.6 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 5.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 2.9 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 3.3 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 0.6 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.1 | 0.8 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 0.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 1.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.4 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.2 | GO:0042285 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 0.0 | 0.8 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 2.2 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.4 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.0 | 1.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.6 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.0 | 0.3 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.0 | 6.4 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 624.2 | GO:0003674 | molecular_function(GO:0003674) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.6 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.3 | 9.5 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.2 | 12.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.2 | 3.0 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 2.5 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 6.4 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.1 | 10.6 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.0 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 3.3 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.9 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 0.8 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 3.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.1 | 2.4 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 1.9 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 2.0 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.9 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 3.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.0 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 1.3 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.4 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.4 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.3 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.4 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.4 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.9 | 5.5 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.5 | 35.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 3.6 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 6.2 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 2.5 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 2.0 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 5.2 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 6.5 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 3.1 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.1 | 4.1 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.1 | 3.5 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.1 | 3.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.6 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.1 | 6.5 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.1 | 0.8 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.5 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 2.1 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 0.8 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.8 | REACTOME_CELL_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 2.1 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 2.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.6 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 5.4 | REACTOME_DIABETES_PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 1.1 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 2.1 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 3.3 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 3.3 | REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 0.2 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 0.4 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 1.7 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 3.2 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
