Motif ID: Tfap2e

Z-value: 0.816


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.626.2e-03Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

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Top targets:


Showing 1 to 20 of 78 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_91945703 5.706 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr11_-_102897123 3.547 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr6_+_108213086 3.484 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr1_+_159737510 2.820 ENSMUST00000111669.3
 Tnr
tenascin R
chr13_+_54949388 1.920 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr11_-_102897146 1.833 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr13_-_101768154 1.572 ENSMUST00000055518.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr8_+_41239718 1.304 ENSMUST00000045218.7
 Pcm1
pericentriolar material 1
chr6_-_137649211 1.159 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
 Eps8


epidermal growth factor receptor pathway substrate 8


chr15_-_102524615 1.135 ENSMUST00000023814.7
 Npff
neuropeptide FF-amide peptide precursor
chr16_+_93832121 1.099 ENSMUST00000044068.6
 Morc3
microrchidia 3
chr12_+_109544498 1.031 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr15_-_58214882 1.021 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr8_+_107293500 1.020 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
 Nfat5


nuclear factor of activated T cells 5


chr8_+_94152607 1.008 ENSMUST00000034211.8
 Mt3
metallothionein 3
chr8_+_107293463 0.974 ENSMUST00000169453.1
 Nfat5
nuclear factor of activated T cells 5
chr6_-_39725193 0.962 ENSMUST00000101497.3
 Braf
Braf transforming gene
chr6_-_39725448 0.948 ENSMUST00000002487.8
 Braf
Braf transforming gene
chr17_+_37046555 0.945 ENSMUST00000172789.1
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr2_+_55437100 0.934 ENSMUST00000112633.2
ENSMUST00000112632.1
 Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.4 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.6 3.5 GO:0042045 epithelial fluid transport(GO:0042045)
0.7 2.8 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.3 2.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 2.0 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 1.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 1.9 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 1.4 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.2 1.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.3 1.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 1.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.3 1.0 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 1.0 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 1.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.5 0.9 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.1 0.9 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.1 0.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.7 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.4 GO:0097450 astrocyte end-foot(GO:0097450)
1.2 3.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.9 2.8 GO:0072534 perineuronal net(GO:0072534)
0.1 2.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.3 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.1 1.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.9 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.1 0.4 GO:0005940 septin ring(GO:0005940)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.2 3.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 2.8 GO:0046625 sphingolipid binding(GO:0046625)
0.3 1.9 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.4 1.6 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 1.2 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 0.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 0.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.5 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.3 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 1.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.0 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 2.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.9 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.9 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.2 1.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)