Motif ID: Klf1

Z-value: 2.899


Transcription factors associated with Klf1:

Gene SymbolEntrez IDGene Name
Klf1 ENSMUSG00000054191.7 Klf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf1mm10_v2_chr8_+_84901928_84901992-0.798.4e-05Click!


Activity profile for motif Klf1.

activity profile for motif Klf1


Sorted Z-values histogram for motif Klf1

Sorted Z-values for motif Klf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_46179929 10.705 ENSMUST00000033123.6
 Abcc8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
chr15_+_83791939 10.495 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr7_+_44310213 9.728 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr6_+_5725639 9.524 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr6_+_103510874 8.672 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr2_-_162661075 8.487 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr5_-_139325616 8.329 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr10_-_81025521 7.822 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr14_+_80000292 7.776 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr10_+_106470281 7.767 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr11_+_104231465 7.659 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr5_+_117781017 7.613 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr11_+_104231515 7.574 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr16_+_91269759 7.335 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_-_103813913 7.141 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr11_+_104231390 7.055 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr10_+_127078886 6.406 ENSMUST00000039259.6
 Agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr12_-_4841583 6.210 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr8_+_84723003 5.978 ENSMUST00000098571.4
 G430095P16Rik
RIKEN cDNA G430095P16 gene
chr10_+_89873497 5.950 ENSMUST00000183156.1
ENSMUST00000182936.1
ENSMUST00000099368.4
 Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 578 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 27.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.6 14.8 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.2 14.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.4 13.5 GO:0046959 habituation(GO:0046959)
1.2 11.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 10.9 GO:0030032 lamellipodium assembly(GO:0030032)
2.0 10.2 GO:1905075 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.6 10.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
3.3 9.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
3.3 9.8 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
2.4 9.5 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.5 9.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
1.8 9.2 GO:0060178 regulation of exocyst localization(GO:0060178)
0.3 9.1 GO:0035640 exploration behavior(GO:0035640)
0.4 8.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.4 8.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.7 8.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 8.0 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.8 7.6 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 7.4 GO:0071805 potassium ion transmembrane transport(GO:0071805)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 28.2 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.4 24.9 GO:0034704 calcium channel complex(GO:0034704)
2.4 23.8 GO:0045298 tubulin complex(GO:0045298)
0.1 17.1 GO:0014069 postsynaptic density(GO:0014069)
0.2 16.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.4 12.9 GO:0030673 axolemma(GO:0030673)
0.7 12.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
2.8 11.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.7 11.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 10.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
2.7 10.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
2.0 9.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 9.8 GO:0016235 aggresome(GO:0016235)
3.2 9.5 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.2 9.3 GO:0005871 kinesin complex(GO:0005871)
0.2 9.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 8.7 GO:0019898 extrinsic component of membrane(GO:0019898)
0.8 8.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 8.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 337 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 37.4 GO:0005096 GTPase activator activity(GO:0005096)
4.2 29.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.3 20.8 GO:0005267 potassium channel activity(GO:0005267)
0.2 13.9 GO:0030507 spectrin binding(GO:0030507)
1.0 13.1 GO:0038191 neuropilin binding(GO:0038191)
3.3 13.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 11.7 GO:0003924 GTPase activity(GO:0003924)
2.8 11.4 GO:0031720 haptoglobin binding(GO:0031720)
0.8 11.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 11.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.8 10.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 10.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 10.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 9.4 GO:0003777 microtubule motor activity(GO:0003777)
0.4 9.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.5 9.0 GO:0045504 dynein heavy chain binding(GO:0045504)
0.5 9.0 GO:0050811 GABA receptor binding(GO:0050811)
0.5 8.6 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 8.0 GO:0030276 clathrin binding(GO:0030276)
0.4 7.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 26.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 16.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 12.0 PID_ARF6_PATHWAY Arf6 signaling events
0.2 11.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 9.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 8.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 8.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.5 7.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 7.2 PID_LKB1_PATHWAY LKB1 signaling events
0.2 6.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 6.7 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.2 4.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2 4.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 4.1 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 3.5 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.6 3.4 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 3.4 PID_SHP2_PATHWAY SHP2 signaling
0.1 3.0 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 29.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 24.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.5 19.4 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.2 15.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.5 12.5 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.2 12.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 11.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 10.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 10.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 9.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3 9.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.4 8.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 7.7 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 7.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 6.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 6.4 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.2 6.2 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.6 6.0 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 5.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.5 5.2 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors