Motif ID: Hnf1b

Z-value: 0.930


Transcription factors associated with Hnf1b:

Gene SymbolEntrez IDGene Name
Hnf1b ENSMUSG00000020679.5 Hnf1b



Activity profile for motif Hnf1b.

activity profile for motif Hnf1b


Sorted Z-values histogram for motif Hnf1b

Sorted Z-values for motif Hnf1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_53286052 3.699 ENSMUST00000021918.8
 Ror2
receptor tyrosine kinase-like orphan receptor 2
chr4_-_106464167 3.341 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr3_-_150073620 2.170 ENSMUST00000057740.5
 Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr9_+_15520830 2.166 ENSMUST00000178999.1
 Smco4
single-pass membrane protein with coiled-coil domains 4
chr10_-_30842765 2.153 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr4_-_134767940 1.985 ENSMUST00000037828.6
 Ldlrap1
low density lipoprotein receptor adaptor protein 1
chr9_-_106158109 1.833 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr15_-_36598019 1.721 ENSMUST00000155116.1
 Pabpc1
poly(A) binding protein, cytoplasmic 1
chr1_-_4880669 1.638 ENSMUST00000078030.3
 Gm6104
predicted gene 6104
chr10_-_7212222 1.547 ENSMUST00000015346.5
 Cnksr3
Cnksr family member 3
chr13_+_4191163 1.537 ENSMUST00000021634.2
 Akr1c13
aldo-keto reductase family 1, member C13
chr10_+_4611971 1.496 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr3_-_138131356 1.459 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr2_+_167777467 1.446 ENSMUST00000139927.1
ENSMUST00000127441.1
 Gm14321

predicted gene 14321

chr10_-_76110956 1.386 ENSMUST00000120757.1
 Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr17_-_35132050 1.294 ENSMUST00000025249.6
 Apom
apolipoprotein M
chr2_+_158768083 1.239 ENSMUST00000029183.2
 Fam83d
family with sequence similarity 83, member D
chr7_+_100537192 1.230 ENSMUST00000120454.1
 Coa4
cytochrome c oxidase assembly factor 4
chr13_+_83738874 1.130 ENSMUST00000052354.4
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr8_-_92355764 1.069 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
 4933436C20Rik



RIKEN cDNA 4933436C20 gene




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.7 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.8 3.3 GO:0001920 negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.1 2.4 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.7 2.2 GO:0003195 tricuspid valve formation(GO:0003195)
0.7 2.0 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.3 1.7 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.4 1.5 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.3 1.5 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.3 1.5 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.2 1.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.5 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.3 1.4 GO:1904659 glucose transmembrane transport(GO:1904659)
0.3 1.3 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.1 1.2 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 1.2 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.1 1.1 GO:0015791 polyol transport(GO:0015791)
0.3 1.0 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.2 0.9 GO:0015705 iodide transport(GO:0015705)
0.1 0.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.9 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.3 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 2.2 GO:0016580 Sin3 complex(GO:0016580)
0.5 2.0 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 1.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.7 GO:0005814 centriole(GO:0005814)
0.0 1.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 1.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 1.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.1 1.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.8 GO:0032156 septin cytoskeleton(GO:0032156)
0.2 0.7 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.2 0.7 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.1 0.6 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.6 GO:0030015 CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0017147 Wnt-protein binding(GO:0017147)
1.1 3.3 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 2.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 2.4 GO:0005319 lipid transporter activity(GO:0005319)
0.7 2.2 GO:0035939 microsatellite binding(GO:0035939)
0.2 2.0 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.0 GO:0008143 poly(A) binding(GO:0008143)
0.1 1.6 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.5 1.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 1.5 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.4 1.5 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.1 1.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 1.2 GO:0019894 kinesin binding(GO:0019894)
0.3 1.1 GO:0015254 glycerol channel activity(GO:0015254)
0.2 0.9 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.2 0.9 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.9 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.9 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.8 GO:0070402 NADPH binding(GO:0070402)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.3 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.7 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 3.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.9 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 0.7 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.5 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.4 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters